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Coexpression cluster:C3954

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Full id: C3954_Preadipocyte_schwannoma_Adipocyte_Ewing_Fibroblast_Myoblast_thyroid



Phase1 CAGE Peaks

Hg19::chr1:240448546..240448559,+p@chr1:240448546..240448559
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Hg19::chr1:240448587..240448603,+p@chr1:240448587..240448603
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Hg19::chr1:240448610..240448624,+p@chr1:240448610..240448624
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
skin fibroblast2.36e-3023
fibroblast2.64e-2475
non-terminally differentiated cell8.15e-15180
preadipocyte2.08e-1412
mesenchymal stem cell of adipose1.49e-108
fibroblast of dermis4.93e-106
fat cell1.07e-0815
preadipocyte of the breast3.99e-073
Uber Anatomy
Ontology termp-valuen
integument3.83e-2045
integumental system3.83e-2045
skin of body8.60e-1840
adipose tissue3.46e-1114
omentum1.12e-106
peritoneum1.12e-106
abdominal cavity1.12e-106
visceral peritoneum1.12e-106
surface structure3.83e-0995
cavity lining1.75e-0812
serous membrane1.75e-0812
Disease
Ontology termp-valuen
musculoskeletal system disease8.83e-105
myotonic disease8.83e-105
muscle tissue disease8.83e-105
myopathy8.83e-105
muscular disease8.83e-105
myotonic dystrophy8.83e-105


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105137.971147625824820.001974187055288560.0115275702710098
STAT3#6774310.51946499715420.0008589184530415310.00643089714798225



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.