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Coexpression cluster:C918

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Full id: C918_Keratinocyte_Mammary_Prostate_Urothelial_salivary_Corneal_Sebocyte



Phase1 CAGE Peaks

Hg19::chr17:38632693..38632717,-p@chr17:38632693..38632717
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Hg19::chr17:38632736..38632762,-p@chr17:38632736..38632762
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Hg19::chr17:38632800..38632814,-p@chr17:38632800..38632814
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Hg19::chr17:38633152..38633204,-p@chr17:38633152..38633204
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Hg19::chr17:38633210..38633225,-p@chr17:38633210..38633225
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Hg19::chr17:38633789..38633809,+p@chr17:38633789..38633809
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Hg19::chr17:38643475..38643497,+p@chr17:38643475..38643497
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Hg19::chr17:38643498..38643544,+p@chr17:38643498..38643544
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Hg19::chr17:73750837..73750879,-p@chr17:73750837..73750879
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.44e-28169
endoderm1.44e-28169
presumptive endoderm1.44e-28169
digestive system1.72e-21155
digestive tract1.72e-21155
primitive gut1.72e-21155
mixed endoderm/mesoderm-derived structure6.93e-19130
subdivision of digestive tract7.68e-18129
endodermal part of digestive tract7.68e-18129
respiratory system1.47e-1772
foregut9.87e-1698
respiratory tract7.64e-1353
segment of respiratory tract6.84e-1246
organ part8.28e-11219
orifice1.60e-1035
respiratory primordium8.62e-1038
endoderm of foregut8.62e-1038
oral opening2.35e-0921
organ6.12e-09511
organ segment7.25e-0997
endo-epithelium1.78e-0882
primordium3.91e-08168
extraembryonic membrane4.57e-0814
membranous layer4.57e-0814
larynx7.77e-089
upper respiratory tract9.18e-0819
mouth1.39e-0728
stomodeum1.39e-0728
multi-tissue structure3.06e-07347
subdivision of head3.31e-0748
embryo4.82e-07612
anatomical space8.73e-07104
immaterial anatomical entity9.53e-07126
Disease
Ontology termp-valuen
carcinoma2.87e-16106
cell type cancer2.81e-10143
squamous cell carcinoma1.22e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.