MCL coexpression mm9:120
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0016829 | lyase activity | 2.46406878638975e-10 |
GO:0019752 | carboxylic acid metabolic process | 1.2404802186074e-06 |
GO:0006082 | organic acid metabolic process | 1.2404802186074e-06 |
GO:0006091 | generation of precursor metabolites and energy | 7.92913539539709e-06 |
GO:0016840 | carbon-nitrogen lyase activity | 7.92913539539709e-06 |
GO:0008652 | amino acid biosynthetic process | 1.26490130989831e-05 |
GO:0009058 | biosynthetic process | 1.53056571506228e-05 |
GO:0006520 | amino acid metabolic process | 2.59911923358682e-05 |
GO:0030170 | pyridoxal phosphate binding | 2.59911923358682e-05 |
GO:0009309 | amine biosynthetic process | 6.43907994795791e-05 |
GO:0044249 | cellular biosynthetic process | 7.10973083443533e-05 |
GO:0006519 | amino acid and derivative metabolic process | 9.5383920542986e-05 |
GO:0048037 | cofactor binding | 0.00012744799389119 |
GO:0044271 | nitrogen compound biosynthetic process | 0.00012744799389119 |
GO:0006118 | electron transport | 0.000141647593964036 |
GO:0016841 | ammonia-lyase activity | 0.000155522459834056 |
GO:0009308 | amine metabolic process | 0.000160458010606437 |
GO:0006807 | nitrogen compound metabolic process | 0.000230437964436646 |
GO:0019842 | vitamin binding | 0.00033980490175647 |
GO:0020037 | heme binding | 0.00037633594414303 |
GO:0046906 | tetrapyrrole binding | 0.00037633594414303 |
GO:0006526 | arginine biosynthetic process | 0.00037633594414303 |
GO:0004497 | monooxygenase activity | 0.00053449510275727 |
GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.00053449510275727 |
GO:0019627 | urea metabolic process | 0.000642777348977239 |
GO:0043603 | amide metabolic process | 0.000642777348977239 |
GO:0000050 | urea cycle | 0.000642777348977239 |
GO:0006525 | arginine metabolic process | 0.00106061135412257 |
GO:0008395 | steroid hydroxylase activity | 0.0012362505274919 |
GO:0000051 | urea cycle intermediate metabolic process | 0.0012362505274919 |
GO:0000097 | sulfur amino acid biosynthetic process | 0.00146089729155016 |
GO:0006694 | steroid biosynthetic process | 0.00174465485454436 |
GO:0009084 | glutamine family amino acid biosynthetic process | 0.00194270274309554 |
GO:0005737 | cytoplasm | 0.002810280143802 |
GO:0000096 | sulfur amino acid metabolic process | 0.002810280143802 |
GO:0006094 | gluconeogenesis | 0.00309368757756801 |
GO:0008610 | lipid biosynthetic process | 0.00402957280668468 |
GO:0006090 | pyruvate metabolic process | 0.00450910727413831 |
GO:0006066 | alcohol metabolic process | 0.00504642292494655 |
GO:0019319 | hexose biosynthetic process | 0.00515137287684028 |
GO:0046165 | alcohol biosynthetic process | 0.00580687030955077 |
GO:0046364 | monosaccharide biosynthetic process | 0.00580687030955077 |
GO:0016831 | carboxy-lyase activity | 0.00613887745983948 |
GO:0016491 | oxidoreductase activity | 0.00626029196735565 |
GO:0044272 | sulfur compound biosynthetic process | 0.00730801525626199 |
GO:0005506 | iron ion binding | 0.00739981816291079 |
GO:0009064 | glutamine family amino acid metabolic process | 0.00748999174324632 |
GO:0008202 | steroid metabolic process | 0.00787578791194636 |
GO:0016874 | ligase activity | 0.00787578791194636 |
GO:0016830 | carbon-carbon lyase activity | 0.00787578791194636 |
GO:0005792 | microsome | 0.00787578791194636 |
GO:0047131 | saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity | 0.00787578791194636 |
GO:0004055 | argininosuccinate synthase activity | 0.00787578791194636 |
GO:0006114 | glycerol biosynthetic process | 0.00787578791194636 |
GO:0004638 | phosphoribosylaminoimidazole carboxylase activity | 0.00787578791194636 |
GO:0006106 | fumarate metabolic process | 0.00787578791194636 |
GO:0046173 | polyol biosynthetic process | 0.00787578791194636 |
GO:0004361 | glutaryl-CoA dehydrogenase activity | 0.00787578791194636 |
GO:0004508 | steroid 17-alpha-monooxygenase activity | 0.00787578791194636 |
GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | 0.00787578791194636 |
GO:0048873 | homeostasis of number of cells within a tissue | 0.00787578791194636 |
GO:0003941 | L-serine ammonia-lyase activity | 0.00787578791194636 |
GO:0004753 | saccharopine dehydrogenase activity | 0.00787578791194636 |
GO:0004333 | fumarate hydratase activity | 0.00787578791194636 |
GO:0004123 | cystathionine gamma-lyase activity | 0.00787578791194636 |
GO:0004397 | histidine ammonia-lyase activity | 0.00787578791194636 |
GO:0042450 | arginine biosynthetic process via ornithine | 0.00787578791194636 |
GO:0004056 | argininosuccinate lyase activity | 0.00787578791194636 |
GO:0008112 | nicotinamide N-methyltransferase activity | 0.00787578791194636 |
GO:0046327 | glycerol biosynthetic process from pyruvate | 0.00787578791194636 |
GO:0009320 | phosphoribosylaminoimidazole carboxylase complex | 0.00787578791194636 |
GO:0033782 | 24-hydroxycholesterol 7alpha-hydroxylase activity | 0.00787578791194636 |
GO:0008387 | steroid 7-alpha-hydroxylase activity | 0.00787578791194636 |
GO:0006113 | fermentation | 0.00787578791194636 |
GO:0042598 | vesicular fraction | 0.00824337815197385 |
GO:0016879 | ligase activity, forming carbon-nitrogen bonds | 0.00843522879042755 |
GO:0005739 | mitochondrion | 0.00981543386523978 |
GO:0009063 | amino acid catabolic process | 0.010582881590535 |
GO:0044248 | cellular catabolic process | 0.0122609094705967 |
GO:0047750 | cholestenol delta-isomerase activity | 0.0122609094705967 |
GO:0006591 | ornithine metabolic process | 0.0122609094705967 |
GO:0008898 | homocysteine S-methyltransferase activity | 0.0122609094705967 |
GO:0046040 | IMP metabolic process | 0.0122609094705967 |
GO:0030573 | bile acid catabolic process | 0.0122609094705967 |
GO:0004613 | phosphoenolpyruvate carboxykinase (GTP) activity | 0.0122609094705967 |
GO:0006189 | 'de novo' IMP biosynthetic process | 0.0122609094705967 |
GO:0000247 | C-8 sterol isomerase activity | 0.0122609094705967 |
GO:0045239 | tricarboxylic acid cycle enzyme complex | 0.0122609094705967 |
GO:0019794 | nonprotein amino acid metabolic process | 0.0122609094705967 |
GO:0006188 | IMP biosynthetic process | 0.0122609094705967 |
GO:0004478 | methionine adenosyltransferase activity | 0.0122609094705967 |
GO:0019344 | cysteine biosynthetic process | 0.0122609094705967 |
GO:0018685 | alkane 1-monooxygenase activity | 0.0122609094705967 |
GO:0004611 | phosphoenolpyruvate carboxykinase activity | 0.0122609094705967 |
GO:0008396 | oxysterol 7-alpha-hydroxylase activity | 0.0122609094705967 |
GO:0044270 | nitrogen compound catabolic process | 0.0125473985545729 |
GO:0009310 | amine catabolic process | 0.0125473985545729 |
GO:0006790 | sulfur metabolic process | 0.0142223492718431 |
GO:0032787 | monocarboxylic acid metabolic process | 0.0148347419016172 |
GO:0008203 | cholesterol metabolic process | 0.0158173818357916 |
GO:0046914 | transition metal ion binding | 0.0159525915927521 |
GO:0015980 | energy derivation by oxidation of organic compounds | 0.0164695349675379 |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 0.0166279563798225 |
GO:0016211 | ammonia ligase activity | 0.0166279563798225 |
GO:0016842 | amidine-lyase activity | 0.0166279563798225 |
GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 0.0177781319082378 |
GO:0016125 | sterol metabolic process | 0.018106007904119 |
GO:0044262 | cellular carbohydrate metabolic process | 0.0204057587870693 |
GO:0000267 | cell fraction | 0.0204057587870693 |
GO:0019432 | triacylglycerol biosynthetic process | 0.0204057587870693 |
GO:0016880 | acid-ammonia (or amide) ligase activity | 0.0204057587870693 |
GO:0006707 | cholesterol catabolic process | 0.0204057587870693 |
GO:0016127 | sterol catabolic process | 0.0204057587870693 |
GO:0006699 | bile acid biosynthetic process | 0.0204057587870693 |
GO:0016051 | carbohydrate biosynthetic process | 0.0207356150081891 |
GO:0044255 | cellular lipid metabolic process | 0.020968864745525 |
GO:0009056 | catabolic process | 0.0238026026116236 |
GO:0016713 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen | 0.0240144692517739 |
GO:0006704 | glucocorticoid biosynthetic process | 0.0240144692517739 |
GO:0006527 | arginine catabolic process | 0.0240144692517739 |
GO:0006534 | cysteine metabolic process | 0.0240144692517739 |
GO:0006706 | steroid catabolic process | 0.0276541221097614 |
GO:0016054 | organic acid catabolic process | 0.0276541221097614 |
GO:0009070 | serine family amino acid biosynthetic process | 0.0276541221097614 |
GO:0008172 | S-methyltransferase activity | 0.0276541221097614 |
GO:0046395 | carboxylic acid catabolic process | 0.0276541221097614 |
GO:0006006 | glucose metabolic process | 0.0279149010725896 |
GO:0044444 | cytoplasmic part | 0.0282629873680856 |
GO:0006629 | lipid metabolic process | 0.030614312507511 |
GO:0046460 | neutral lipid biosynthetic process | 0.0307747231217011 |
GO:0005941 | unlocalized protein complex | 0.0307747231217011 |
GO:0046463 | acylglycerol biosynthetic process | 0.0307747231217011 |
GO:0046504 | glycerol ether biosynthetic process | 0.033863387649073 |
GO:0006857 | oligopeptide transport | 0.033863387649073 |
GO:0045017 | glycerolipid biosynthetic process | 0.033863387649073 |
GO:0009086 | methionine biosynthetic process | 0.033863387649073 |
GO:0006555 | methionine metabolic process | 0.033863387649073 |
GO:0009065 | glutamine family amino acid catabolic process | 0.0362186283449585 |
GO:0042771 | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | 0.0362186283449585 |
GO:0006548 | histidine catabolic process | 0.0362186283449585 |
GO:0043648 | dicarboxylic acid metabolic process | 0.0362186283449585 |
GO:0009077 | histidine family amino acid catabolic process | 0.0362186283449585 |
GO:0008211 | glucocorticoid metabolic process | 0.0362186283449585 |
GO:0016846 | carbon-sulfur lyase activity | 0.0362186283449585 |
GO:0005975 | carbohydrate metabolic process | 0.038614812289494 |
GO:0006547 | histidine metabolic process | 0.0388648302020247 |
GO:0009168 | purine ribonucleoside monophosphate biosynthetic process | 0.0388648302020247 |
GO:0009075 | histidine family amino acid metabolic process | 0.0388648302020247 |
GO:0009127 | purine nucleoside monophosphate biosynthetic process | 0.0388648302020247 |
GO:0019318 | hexose metabolic process | 0.04106720573231 |
GO:0008206 | bile acid metabolic process | 0.04106720573231 |
GO:0009167 | purine ribonucleoside monophosphate metabolic process | 0.04106720573231 |
GO:0009126 | purine nucleoside monophosphate metabolic process | 0.04106720573231 |
GO:0050897 | cobalt ion binding | 0.04106720573231 |
GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | 0.04106720573231 |
GO:0005996 | monosaccharide metabolic process | 0.0420603793328592 |
GO:0005783 | endoplasmic reticulum | 0.0421169627800431 |
GO:0009067 | aspartate family amino acid biosynthetic process | 0.0439187036121171 |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 0.0469504729316484 |
GO:0009156 | ribonucleoside monophosphate biosynthetic process | 0.0469504729316484 |
GO:0044424 | intracellular part | 0.047539792919115 |
GO:0006700 | C21-steroid hormone biosynthetic process | 0.0492937774659894 |
GO:0009161 | ribonucleoside monophosphate metabolic process | 0.0492937774659894 |
GO:0009066 | aspartate family amino acid metabolic process | 0.0492937774659894 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
metabolising cell | 1.26e-09 | 5 |
endopolyploid cell | 1.26e-09 | 5 |
parenchymal cell | 1.26e-09 | 5 |
polyploid cell | 1.26e-09 | 5 |
hepatocyte | 1.26e-09 | 5 |
Ontology term | p-value | n |
---|---|---|
liver | 3.77e-26 | 22 |
epithelial sac | 3.77e-26 | 22 |
digestive gland | 3.77e-26 | 22 |
epithelium of foregut-midgut junction | 3.77e-26 | 22 |
anatomical boundary | 3.77e-26 | 22 |
hepatobiliary system | 3.77e-26 | 22 |
foregut-midgut junction | 3.77e-26 | 22 |
hepatic diverticulum | 3.77e-26 | 22 |
liver primordium | 3.77e-26 | 22 |
septum transversum | 3.77e-26 | 22 |
liver bud | 3.77e-26 | 22 |
digestive tract diverticulum | 7.39e-25 | 23 |
sac | 7.39e-25 | 23 |
exocrine gland | 1.39e-22 | 25 |
exocrine system | 1.39e-22 | 25 |
abdomen element | 3.80e-18 | 49 |
abdominal segment element | 3.80e-18 | 49 |
abdominal segment of trunk | 3.80e-18 | 49 |
abdomen | 3.80e-18 | 49 |
mesenchyme | 1.17e-13 | 61 |
entire embryonic mesenchyme | 1.17e-13 | 61 |
trunk mesenchyme | 1.43e-12 | 45 |
subdivision of trunk | 2.84e-12 | 66 |
epithelial tube | 2.31e-10 | 47 |
trunk region element | 1.69e-09 | 79 |
endocrine gland | 1.65e-08 | 60 |
gut epithelium | 2.33e-08 | 55 |
trunk | 8.69e-08 | 90 |
gland | 1.40e-07 | 65 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 1.23958e-07 |
MA0004.1 | 0.918618 |
MA0006.1 | 0.0181544 |
MA0007.1 | 2.09923 |
MA0009.1 | 0.968397 |
MA0014.1 | 0.000622476 |
MA0017.1 | 1.77598 |
MA0019.1 | 0.267505 |
MA0024.1 | 1.7818 |
MA0025.1 | 1.07965 |
MA0027.1 | 1.43248 |
MA0028.1 | 0.00831229 |
MA0029.1 | 0.451892 |
MA0030.1 | 1.71048 |
MA0031.1 | 1.5463 |
MA0038.1 | 0.733394 |
MA0040.1 | 1.0045 |
MA0041.1 | 1.24405 |
MA0042.1 | 1.42067 |
MA0043.1 | 0.121079 |
MA0046.1 | 1.07315 |
MA0048.1 | 0.00325561 |
MA0050.1 | 1.45825 |
MA0051.1 | 0.765293 |
MA0052.1 | 0.0872399 |
MA0055.1 | 0.0078335 |
MA0056.1 | 0 |
MA0057.1 | 0.0425324 |
MA0058.1 | 0.855517 |
MA0059.1 | 0.137037 |
MA0060.1 | 1.08697 |
MA0061.1 | 0.166346 |
MA0063.1 | 0 |
MA0066.1 | 0.0447636 |
MA0067.1 | 0.26661 |
MA0068.1 | 0.0489802 |
MA0069.1 | 0.294567 |
MA0070.1 | 0.594575 |
MA0071.1 | 1.81148 |
MA0072.1 | 1.45565 |
MA0073.1 | 3.32886e-12 |
MA0074.1 | 0.0944337 |
MA0076.1 | 0.00517167 |
MA0077.1 | 0.536689 |
MA0078.1 | 0.180169 |
MA0081.1 | 0.0434427 |
MA0083.1 | 0.383273 |
MA0084.1 | 0.519277 |
MA0087.1 | 1.12356 |
MA0088.1 | 0.00670682 |
MA0089.1 | 0 |
MA0090.1 | 0.225391 |
MA0091.1 | 0.989751 |
MA0092.1 | 0.535064 |
MA0093.1 | 1.68802 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0855528 |
MA0101.1 | 0.151281 |
MA0103.1 | 0.220139 |
MA0105.1 | 0.117918 |
MA0106.1 | 0.369858 |
MA0107.1 | 0.0676497 |
MA0108.2 | 0.300139 |
MA0109.1 | 0 |
MA0111.1 | 0.145121 |
MA0113.1 | 1.51766 |
MA0114.1 | 1.91726 |
MA0115.1 | 0.776172 |
MA0116.1 | 0.609296 |
MA0117.1 | 0.348218 |
MA0119.1 | 0.760647 |
MA0122.1 | 0.116491 |
MA0124.1 | 0.231301 |
MA0125.1 | 0.185604 |
MA0130.1 | 0 |
MA0131.1 | 0.261233 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.430741 |
MA0136.1 | 0.233874 |
MA0139.1 | 0.00638282 |
MA0140.1 | 0.00507345 |
MA0141.1 | 2.47891 |
MA0142.1 | 0.673596 |
MA0143.1 | 0.346915 |
MA0144.1 | 3.59833 |
MA0145.1 | 0.185231 |
MA0146.1 | 0.000921524 |
MA0147.1 | 0.295299 |
MA0148.1 | 0.744773 |
MA0149.1 | 0.00336254 |
MA0062.2 | 0.032981 |
MA0035.2 | 0.806397 |
MA0039.2 | 0.00952053 |
MA0138.2 | 0.471207 |
MA0002.2 | 0.506078 |
MA0137.2 | 2.44094 |
MA0104.2 | 0.120988 |
MA0047.2 | 0.730685 |
MA0112.2 | 0.388047 |
MA0065.2 | 2.21897 |
MA0150.1 | 0.266295 |
MA0151.1 | 0 |
MA0152.1 | 0.476413 |
MA0153.1 | 0.886563 |
MA0154.1 | 0.886795 |
MA0155.1 | 0.353309 |
MA0156.1 | 0.5083 |
MA0157.1 | 0.59451 |
MA0158.1 | 0 |
MA0159.1 | 0.46179 |
MA0160.1 | 1.0234 |
MA0161.1 | 0 |
MA0162.1 | 9.90486e-06 |
MA0163.1 | 0.00724107 |
MA0164.1 | 0.641682 |
MA0080.2 | 0.125556 |
MA0018.2 | 0.964617 |
MA0099.2 | 1.08557 |
MA0079.2 | 9.97437e-06 |
MA0102.2 | 0.563914 |
MA0258.1 | 0.196441 |
MA0259.1 | 0.00608838 |
MA0442.1 | 0 |