MCL coexpression mm9:71
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0016042 | lipid catabolic process | 0.0029286779344968 |
| GO:0004623 | phospholipase A2 activity | 0.00530930889302839 |
| GO:0016787 | hydrolase activity | 0.0176780471448425 |
| GO:0004175 | endopeptidase activity | 0.018306204847719 |
| GO:0006629 | lipid metabolic process | 0.018306204847719 |
| GO:0004620 | phospholipase activity | 0.018306204847719 |
| GO:0006508 | proteolysis | 0.018306204847719 |
| GO:0006644 | phospholipid metabolic process | 0.018306204847719 |
| GO:0004293 | tissue kallikrein activity | 0.0290738219152611 |
| GO:0004866 | endopeptidase inhibitor activity | 0.0290738219152611 |
| GO:0016298 | lipase activity | 0.0290738219152611 |
| GO:0030414 | protease inhibitor activity | 0.0290738219152611 |
| GO:0006643 | membrane lipid metabolic process | 0.0304293930543865 |
| GO:0001533 | cornified envelope | 0.0384357979093 |
| GO:0004252 | serine-type endopeptidase activity | 0.0384357979093 |
| GO:0005884 | actin filament | 0.0384357979093 |
| GO:0017171 | serine hydrolase activity | 0.0384357979093 |
| GO:0008236 | serine-type peptidase activity | 0.0384357979093 |
| GO:0008233 | peptidase activity | 0.0384357979093 |
| GO:0005856 | cytoskeleton | 0.0384357979093 |
| GO:0004857 | enzyme inhibitor activity | 0.0384357979093 |
| GO:0043089 | positive regulation of Cdc42 GTPase activity | 0.0384357979093 |
| GO:0043088 | regulation of Cdc42 GTPase activity | 0.0384357979093 |
| GO:0008747 | N-acetylneuraminate lyase activity | 0.0384357979093 |
| GO:0032489 | regulation of Cdc42 protein signal transduction | 0.0384357979093 |
| GO:0016919 | nardilysin activity | 0.0384357979093 |
| GO:0008605 | protein kinase CK2 regulator activity | 0.0384357979093 |
| GO:0008423 | bleomycin hydrolase activity | 0.0384357979093 |
| GO:0032488 | Cdc42 protein signal transduction | 0.0384357979093 |
| GO:0043758 | acetate-CoA ligase (ADP-forming) activity | 0.0384357979093 |
| GO:0004869 | cysteine protease inhibitor activity | 0.0384357979093 |
| GO:0044255 | cellular lipid metabolic process | 0.0395819923507891 |
| GO:0004091 | carboxylesterase activity | 0.0409526949257572 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| zone of skin | 6.24e-11 | 5 |
| skin epidermis | 6.24e-11 | 5 |
| skin of body | 6.24e-11 | 5 |
| integument | 6.24e-11 | 5 |
| surface | 6.24e-11 | 5 |
| outer epithelium | 6.24e-11 | 5 |
| integumental system | 6.24e-11 | 5 |
| enveloping layer of ectoderm | 6.24e-11 | 5 |
| surface structure | 1.97e-07 | 22 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 4.82164e-17 |
| MA0004.1 | 0.000503271 |
| MA0006.1 | 9.93368e-05 |
| MA0007.1 | 0.0513924 |
| MA0009.1 | 0.562872 |
| MA0014.1 | 1.44649e-16 |
| MA0017.1 | 0.0223154 |
| MA0019.1 | 0.963199 |
| MA0024.1 | 0.127019 |
| MA0025.1 | 0.855857 |
| MA0027.1 | 1.15025 |
| MA0028.1 | 0.00334739 |
| MA0029.1 | 1.60233 |
| MA0030.1 | 0.239732 |
| MA0031.1 | 0.545776 |
| MA0038.1 | 0.486757 |
| MA0040.1 | 0.0696449 |
| MA0041.1 | 0.0155896 |
| MA0042.1 | 0.700216 |
| MA0043.1 | 0.525524 |
| MA0046.1 | 0.0181068 |
| MA0048.1 | 0.0195351 |
| MA0050.1 | 0.392738 |
| MA0051.1 | 0.0316155 |
| MA0052.1 | 0.372199 |
| MA0055.1 | 0.0293001 |
| MA0056.1 | 0 |
| MA0057.1 | 1.90742e-05 |
| MA0058.1 | 0.000480507 |
| MA0059.1 | 0.0261421 |
| MA0060.1 | 0.151774 |
| MA0061.1 | 0.00167916 |
| MA0063.1 | 0 |
| MA0066.1 | 0.621368 |
| MA0067.1 | 0.107298 |
| MA0068.1 | 0.000547762 |
| MA0069.1 | 0.92301 |
| MA0070.1 | 0.888181 |
| MA0071.1 | 0.273431 |
| MA0072.1 | 0.0137101 |
| MA0073.1 | 9.64327e-17 |
| MA0074.1 | 0.0737943 |
| MA0076.1 | 0.00444516 |
| MA0077.1 | 0.514756 |
| MA0078.1 | 1.4161 |
| MA0081.1 | 0.350182 |
| MA0083.1 | 0.283031 |
| MA0084.1 | 0.297088 |
| MA0087.1 | 0.227767 |
| MA0088.1 | 0.05097 |
| MA0089.1 | 0 |
| MA0090.1 | 1.14806 |
| MA0091.1 | 0.207635 |
| MA0092.1 | 0.950461 |
| MA0093.1 | 5.92044e-05 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.0636466 |
| MA0101.1 | 0.0160577 |
| MA0103.1 | 0.665459 |
| MA0105.1 | 1.64548e-09 |
| MA0106.1 | 0.682111 |
| MA0107.1 | 0.0435709 |
| MA0108.2 | 1.39172 |
| MA0109.1 | 0 |
| MA0111.1 | 0.69352 |
| MA0113.1 | 0.0370831 |
| MA0114.1 | 0.034344 |
| MA0115.1 | 0.0290864 |
| MA0116.1 | 0.31634 |
| MA0117.1 | 0.0996328 |
| MA0119.1 | 0.00290226 |
| MA0122.1 | 0.112119 |
| MA0124.1 | 0.603423 |
| MA0125.1 | 1.23555 |
| MA0130.1 | 0 |
| MA0131.1 | 0.0916901 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.0363595 |
| MA0136.1 | 0.265282 |
| MA0139.1 | 0.000162419 |
| MA0140.1 | 1.22821 |
| MA0141.1 | 0.0132757 |
| MA0142.1 | 1.0252 |
| MA0143.1 | 0.296726 |
| MA0144.1 | 0.122404 |
| MA0145.1 | 0.611799 |
| MA0146.1 | 6.06488e-06 |
| MA0147.1 | 5.75865e-05 |
| MA0148.1 | 0.215252 |
| MA0149.1 | 0.0624869 |
| MA0062.2 | 3.59778e-06 |
| MA0035.2 | 1.53364 |
| MA0039.2 | 3.4291e-08 |
| MA0138.2 | 0.170317 |
| MA0002.2 | 0.353692 |
| MA0137.2 | 0.162579 |
| MA0104.2 | 2.248e-05 |
| MA0047.2 | 0.213349 |
| MA0112.2 | 6.28056e-05 |
| MA0065.2 | 0.0130664 |
| MA0150.1 | 1.10564 |
| MA0151.1 | 0 |
| MA0152.1 | 2.02487 |
| MA0153.1 | 0.157169 |
| MA0154.1 | 0.187973 |
| MA0155.1 | 0.000286752 |
| MA0156.1 | 0.138742 |
| MA0157.1 | 0.419164 |
| MA0158.1 | 0 |
| MA0159.1 | 0.0686415 |
| MA0160.1 | 0.047438 |
| MA0161.1 | 0 |
| MA0162.1 | 4.03135e-08 |
| MA0163.1 | 1.32176e-09 |
| MA0164.1 | 0.743721 |
| MA0080.2 | 0.0719857 |
| MA0018.2 | 0.00727692 |
| MA0099.2 | 1.79033 |
| MA0079.2 | 0 |
| MA0102.2 | 0.88939 |
| MA0258.1 | 0.209272 |
| MA0259.1 | 3.25897e-05 |
| MA0442.1 | 0 |
