Coexpression cluster:C1137
From FANTOM5_SSTAR
Full id: C1137_CD4_CD8_thymus_Natural_blood_Whole_Peripheral
Phase1 CAGE Peaks
Hg19::chr11:14671615..14671618,+ | p@chr11:14671615..14671618 + |
Hg19::chr14:105944163..105944184,+ | p@chr14:105944163..105944184 + |
Hg19::chr14:22265481..22265487,+ | p5@TRAV8-1 |
Hg19::chr4:109088233..109088240,- | p62@LEF1 |
Hg19::chr5:133449741..133449744,- | p@chr5:133449741..133449744 - |
Hg19::chr7:142021271..142021284,+ | p1@AF020656 p1@AF325867 p1@AF395795 p1@AY611551 p1@AY751843 p1@AY751887 p1@AY751915 p1@EF592002 p1@GQ502881 p1@GQ502883 p1@HM236508 p1@HM236510 p1@HM236512 p1@HM236514 p1@HM236515 p1@HM236544 p1@HM236615 p1@HM236635 p1@HM236642 p1@HM236659 p1@HM236662 p1@HM236673 p1@HM236674 p1@HM236676 p1@HM236718 p1@HM236776 p1@HM236777 p1@HM236807 p1@HM467843 p1@HM467856 p1@HM467875 p1@HM467876 p1@HM467877 p1@HM467878 p1@JF731146 p1@JF731148 p1@JF731150 |
Hg19::chrX:11776810..11776821,+ | p17@MSL3 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0021542 | dentate gyrus development | 0.00376780878370423 |
GO:0021766 | hippocampus development | 0.00376780878370423 |
GO:0048341 | paraxial mesoderm formation | 0.00376780878370423 |
GO:0048340 | paraxial mesoderm morphogenesis | 0.00376780878370423 |
GO:0048339 | paraxial mesoderm development | 0.00376780878370423 |
GO:0021543 | pallium development | 0.00376780878370423 |
GO:0021761 | limbic system development | 0.00376780878370423 |
GO:0045843 | negative regulation of striated muscle development | 0.00376780878370423 |
GO:0008301 | DNA bending activity | 0.00397713149391001 |
GO:0021537 | telencephalon development | 0.00397713149391001 |
GO:0016202 | regulation of striated muscle development | 0.00397713149391001 |
GO:0030879 | mammary gland development | 0.00397713149391001 |
GO:0001890 | placenta development | 0.00397713149391001 |
GO:0001707 | mesoderm formation | 0.00397713149391001 |
GO:0048332 | mesoderm morphogenesis | 0.00397713149391001 |
GO:0001704 | formation of primary germ layer | 0.00397713149391001 |
GO:0001756 | somitogenesis | 0.00397713149391001 |
GO:0042475 | odontogenesis of dentine-containing teeth | 0.00397713149391001 |
GO:0042476 | odontogenesis | 0.00442307987652235 |
GO:0007369 | gastrulation | 0.00442307987652235 |
GO:0035282 | segmentation | 0.00442307987652235 |
GO:0003705 | RNA polymerase II transcription factor activity, enhancer binding | 0.00442307987652235 |
GO:0030111 | regulation of Wnt receptor signaling pathway | 0.00442307987652235 |
GO:0030326 | embryonic limb morphogenesis | 0.00480720431024332 |
GO:0035113 | embryonic appendage morphogenesis | 0.00480720431024332 |
GO:0060173 | limb development | 0.00480720431024332 |
GO:0035107 | appendage morphogenesis | 0.00480720431024332 |
GO:0035108 | limb morphogenesis | 0.00480720431024332 |
GO:0048736 | appendage development | 0.00480720431024332 |
GO:0007498 | mesoderm development | 0.00541622512657482 |
GO:0030900 | forebrain development | 0.00541622512657482 |
GO:0048732 | gland development | 0.00541622512657482 |
GO:0009952 | anterior/posterior pattern formation | 0.00627968130617371 |
GO:0048729 | tissue morphogenesis | 0.00797888918902071 |
GO:0003002 | regionalization | 0.00917799575517696 |
GO:0014706 | striated muscle development | 0.00917799575517696 |
GO:0048598 | embryonic morphogenesis | 0.00917799575517696 |
GO:0009792 | embryonic development ending in birth or egg hatching | 0.00917799575517696 |
GO:0043009 | chordate embryonic development | 0.00917799575517696 |
GO:0003682 | chromatin binding | 0.0111150359119275 |
GO:0007389 | pattern specification process | 0.011393136084058 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 0.011393136084058 |
GO:0007420 | brain development | 0.0119028504757929 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 0.0119028504757929 |
GO:0016055 | Wnt receptor signaling pathway | 0.0121407171919358 |
GO:0048646 | anatomical structure formation | 0.0125320596501467 |
GO:0007517 | muscle development | 0.0137885768254708 |
GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0159346913144158 |
GO:0005667 | transcription factor complex | 0.016147751930161 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.0168044271753208 |
GO:0007417 | central nervous system development | 0.0170275973878941 |
GO:0009790 | embryonic development | 0.0170275973878941 |
GO:0003702 | RNA polymerase II transcription factor activity | 0.0194670120491385 |
GO:0045941 | positive regulation of transcription | 0.0194670120491385 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0195791492153202 |
GO:0016481 | negative regulation of transcription | 0.0195791492153202 |
GO:0009888 | tissue development | 0.0200733261062863 |
GO:0016563 | transcription activator activity | 0.0200733261062863 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.020371711898333 |
GO:0009887 | organ morphogenesis | 0.0225450853451154 |
GO:0031325 | positive regulation of cellular metabolic process | 0.0225450853451154 |
GO:0031324 | negative regulation of cellular metabolic process | 0.0231537926869566 |
GO:0009893 | positive regulation of metabolic process | 0.0233843370544183 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0249028611797951 |
GO:0009892 | negative regulation of metabolic process | 0.0252733019953083 |
GO:0044451 | nucleoplasm part | 0.0258037813671865 |
GO:0005654 | nucleoplasm | 0.0291864590857088 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.0354617297289809 |
GO:0031981 | nuclear lumen | 0.0376780878370422 |
GO:0007399 | nervous system development | 0.0385393012733175 |
GO:0009966 | regulation of signal transduction | 0.0424541834783575 |
GO:0043565 | sequence-specific DNA binding | 0.0456323508248623 |
GO:0048522 | positive regulation of cellular process | 0.0487805643863574 |
GO:0031974 | membrane-enclosed lumen | 0.0487805643863574 |
GO:0043233 | organelle lumen | 0.0487805643863574 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
thymus | 5.61e-11 | 4 |
hemolymphoid system gland | 5.61e-11 | 4 |
thymic region | 5.61e-11 | 4 |
pharyngeal gland | 5.61e-11 | 4 |
thymus primordium | 5.61e-11 | 4 |
pharyngeal epithelium | 1.88e-07 | 6 |
chordate pharynx | 2.69e-07 | 10 |
pharyngeal region of foregut | 2.69e-07 | 10 |
blood | 5.79e-07 | 15 |
haemolymphatic fluid | 5.79e-07 | 15 |
organism substance | 5.79e-07 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.110456 |
MA0004.1 | 0.502801 |
MA0006.1 | 0.341337 |
MA0007.1 | 1.21493 |
MA0009.1 | 0.973289 |
MA0014.1 | 0.187674 |
MA0017.1 | 0.380797 |
MA0019.1 | 0.652951 |
MA0024.1 | 0.867125 |
MA0025.1 | 1.10816 |
MA0027.1 | 2.59001 |
MA0028.1 | 0.35747 |
MA0029.1 | 0.886702 |
MA0030.1 | 0.875089 |
MA0031.1 | 0.809638 |
MA0038.1 | 0.60704 |
MA0040.1 | 0.892629 |
MA0041.1 | 0.521615 |
MA0042.1 | 0.48922 |
MA0043.1 | 0.973609 |
MA0046.1 | 0.962263 |
MA0048.1 | 0.120314 |
MA0050.1 | 0.490116 |
MA0051.1 | 0.602745 |
MA0052.1 | 0.896548 |
MA0055.1 | 0.158296 |
MA0056.1 | 0 |
MA0057.1 | 0.115382 |
MA0058.1 | 0.406232 |
MA0059.1 | 0.404929 |
MA0060.1 | 0.224688 |
MA0061.1 | 0.575931 |
MA0063.1 | 0 |
MA0066.1 | 0.607474 |
MA0067.1 | 1.29359 |
MA0068.1 | 0.946606 |
MA0069.1 | 0.958358 |
MA0070.1 | 0.947018 |
MA0071.1 | 0.567661 |
MA0072.1 | 0.942461 |
MA0073.1 | 4.49289 |
MA0074.1 | 0.60198 |
MA0076.1 | 0.422297 |
MA0077.1 | 0.934645 |
MA0078.1 | 0.703614 |
MA0081.1 | 0.405093 |
MA0083.1 | 0.980893 |
MA0084.1 | 1.48179 |
MA0087.1 | 0.939982 |
MA0088.1 | 0.538456 |
MA0089.1 | 0 |
MA0090.1 | 0.436918 |
MA0091.1 | 0.505453 |
MA0092.1 | 0.467172 |
MA0093.1 | 0.344385 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.621149 |
MA0101.1 | 0.347695 |
MA0103.1 | 1.58817 |
MA0105.1 | 0.104569 |
MA0106.1 | 0.648997 |
MA0107.1 | 0.274127 |
MA0108.2 | 0.806528 |
MA0109.1 | 0 |
MA0111.1 | 0.45062 |
MA0113.1 | 0.665691 |
MA0114.1 | 0.269076 |
MA0115.1 | 1.21667 |
MA0116.1 | 0.277571 |
MA0117.1 | 1.01134 |
MA0119.1 | 0.388712 |
MA0122.1 | 1.03753 |
MA0124.1 | 1.17486 |
MA0125.1 | 1.0901 |
MA0130.1 | 0 |
MA0131.1 | 0.722072 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 1.00402 |
MA0136.1 | 0.614215 |
MA0139.1 | 0.547495 |
MA0140.1 | 0.564957 |
MA0141.1 | 0.403171 |
MA0142.1 | 0.777365 |
MA0143.1 | 0.66587 |
MA0144.1 | 0.254954 |
MA0145.1 | 0.0807715 |
MA0146.1 | 0.162729 |
MA0147.1 | 0.281049 |
MA0148.1 | 0.528066 |
MA0149.1 | 0.555119 |
MA0062.2 | 0.193221 |
MA0035.2 | 0.564239 |
MA0039.2 | 0.128723 |
MA0138.2 | 0.704862 |
MA0002.2 | 0.611548 |
MA0137.2 | 0.36398 |
MA0104.2 | 0.223944 |
MA0047.2 | 0.636643 |
MA0112.2 | 0.556641 |
MA0065.2 | 0.0828768 |
MA0150.1 | 0.430951 |
MA0151.1 | 0 |
MA0152.1 | 0.571637 |
MA0153.1 | 1.07307 |
MA0154.1 | 0.102476 |
MA0155.1 | 0.250175 |
MA0156.1 | 0.36627 |
MA0157.1 | 0.749547 |
MA0158.1 | 0 |
MA0159.1 | 0.281681 |
MA0160.1 | 0.543522 |
MA0161.1 | 0 |
MA0162.1 | 1.55314 |
MA0163.1 | 0.0167306 |
MA0164.1 | 0.678332 |
MA0080.2 | 0.911393 |
MA0018.2 | 0.650405 |
MA0099.2 | 0.572 |
MA0079.2 | 0.478894 |
MA0102.2 | 1.51913 |
MA0258.1 | 0.245543 |
MA0259.1 | 0.289405 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.