MCL coexpression mm9:298
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005634 | nucleus | 3.76419046431649e-05 |
| GO:0043283 | biopolymer metabolic process | 0.000311836934344768 |
| GO:0043170 | macromolecule metabolic process | 0.000497536975592701 |
| GO:0043231 | intracellular membrane-bound organelle | 0.000586687245999991 |
| GO:0043227 | membrane-bound organelle | 0.000586687245999991 |
| GO:0003676 | nucleic acid binding | 0.000746427899461023 |
| GO:0016070 | RNA metabolic process | 0.000774831726398036 |
| GO:0016485 | protein processing | 0.00127511598646046 |
| GO:0006397 | mRNA processing | 0.0019505498710537 |
| GO:0044238 | primary metabolic process | 0.0019505498710537 |
| GO:0044237 | cellular metabolic process | 0.0019505498710537 |
| GO:0010467 | gene expression | 0.0019505498710537 |
| GO:0043229 | intracellular organelle | 0.0019505498710537 |
| GO:0043226 | organelle | 0.0019505498710537 |
| GO:0016071 | mRNA metabolic process | 0.0019505498710537 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00383249314735907 |
| GO:0003677 | DNA binding | 0.00418382364513257 |
| GO:0044424 | intracellular part | 0.00494269684193766 |
| GO:0006396 | RNA processing | 0.00494269684193766 |
| GO:0006350 | transcription | 0.00494269684193766 |
| GO:0046777 | protein amino acid autophosphorylation | 0.00615239353534538 |
| GO:0016540 | protein autoprocessing | 0.00660974729994499 |
| GO:0005622 | intracellular | 0.00668764818428192 |
| GO:0018212 | peptidyl-tyrosine modification | 0.0143628569552499 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 0.0143628569552499 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.0143628569552499 |
| GO:0006351 | transcription, DNA-dependent | 0.0145152041548976 |
| GO:0032774 | RNA biosynthetic process | 0.0145152041548976 |
| GO:0045449 | regulation of transcription | 0.0160271656701653 |
| GO:0003723 | RNA binding | 0.0160271656701653 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0172785291018028 |
| GO:0010468 | regulation of gene expression | 0.0218552790271866 |
| GO:0031323 | regulation of cellular metabolic process | 0.026685242233463 |
| GO:0018193 | peptidyl-amino acid modification | 0.0288652314441864 |
| GO:0004652 | polynucleotide adenylyltransferase activity | 0.0288652314441864 |
| GO:0019222 | regulation of metabolic process | 0.0300666077364779 |
| GO:0048505 | regulation of timing of cell differentiation | 0.0332166159399697 |
| GO:0040034 | regulation of development, heterochronic | 0.0332166159399697 |
| GO:0016486 | peptide hormone processing | 0.0430581140249115 |
| GO:0018210 | peptidyl-threonine modification | 0.0430581140249115 |
| GO:0018107 | peptidyl-threonine phosphorylation | 0.0430581140249115 |
| GO:0001837 | epithelial to mesenchymal transition | 0.0480139548102052 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| lymphocyte | 7.61e-08 | 13 |
| common lymphoid progenitor | 7.61e-08 | 13 |
| lymphoid lineage restricted progenitor cell | 8.35e-08 | 12 |
| T cell | 3.77e-07 | 11 |
| pro-T cell | 3.77e-07 | 11 |
| Ontology term | p-value | n |
|---|---|---|
| anterior region of body | 5.67e-08 | 43 |
| craniocervical region | 1.40e-07 | 36 |
| respiratory tract | 1.97e-07 | 41 |
| respiratory system | 2.68e-07 | 42 |
| hemopoietic organ | 2.73e-07 | 29 |
| immune organ | 2.73e-07 | 29 |
| mixed endoderm/mesoderm-derived structure | 6.56e-07 | 35 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
