MCL coexpression mm9:78
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030017 | sarcomere | 0.0104023996055443 |
| GO:0044449 | contractile fiber part | 0.0104023996055443 |
| GO:0030016 | myofibril | 0.0104023996055443 |
| GO:0043292 | contractile fiber | 0.0104023996055443 |
| GO:0004674 | protein serine/threonine kinase activity | 0.0104023996055443 |
| GO:0031430 | M band | 0.0104023996055443 |
| GO:0004133 | glycogen debranching enzyme activity | 0.0104023996055443 |
| GO:0043056 | forward locomotion | 0.0104023996055443 |
| GO:0005200 | structural constituent of cytoskeleton | 0.0114542433645602 |
| GO:0005516 | calmodulin binding | 0.0151282760864326 |
| GO:0031672 | A band | 0.0151282760864326 |
| GO:0001701 | in utero embryonic development | 0.0156671893230109 |
| GO:0004672 | protein kinase activity | 0.0157033208341587 |
| GO:0006468 | protein amino acid phosphorylation | 0.0166383685209199 |
| GO:0033058 | directional locomotion | 0.0166383685209199 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.0175111935224429 |
| GO:0016310 | phosphorylation | 0.0175111935224429 |
| GO:0005862 | muscle thin filament tropomyosin | 0.0175111935224429 |
| GO:0055003 | cardiac myofibril assembly | 0.0175111935224429 |
| GO:0007507 | heart development | 0.0190542979056395 |
| GO:0015629 | actin cytoskeleton | 0.0201020100293696 |
| GO:0016740 | transferase activity | 0.0201020100293696 |
| GO:0055013 | cardiac muscle cell development | 0.0201020100293696 |
| GO:0005954 | calcium- and calmodulin-dependent protein kinase complex | 0.0201020100293696 |
| GO:0006793 | phosphorus metabolic process | 0.0201020100293696 |
| GO:0006796 | phosphate metabolic process | 0.0201020100293696 |
| GO:0031941 | filamentous actin | 0.0214512259894864 |
| GO:0043009 | chordate embryonic development | 0.0214512259894864 |
| GO:0016301 | kinase activity | 0.0214512259894864 |
| GO:0009792 | embryonic development ending in birth or egg hatching | 0.0214512259894864 |
| GO:0035254 | glutamate receptor binding | 0.0214512259894864 |
| GO:0007512 | adult heart development | 0.0233746424491024 |
| GO:0045214 | sarcomere organization | 0.0251806610376127 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 0.0282744609746378 |
| GO:0030239 | myofibril assembly | 0.0305942636592916 |
| GO:0005859 | muscle myosin complex | 0.0305942636592916 |
| GO:0055002 | striated muscle cell development | 0.0305942636592916 |
| GO:0004683 | calmodulin-dependent protein kinase activity | 0.0305942636592916 |
| GO:0055001 | muscle cell development | 0.0319338180250203 |
| GO:0016460 | myosin II complex | 0.0322924246582231 |
| GO:0005865 | striated muscle thin filament | 0.0322924246582231 |
| GO:0006996 | organelle organization and biogenesis | 0.0322924246582231 |
| GO:0004709 | MAP kinase kinase kinase activity | 0.0322924246582231 |
| GO:0016043 | cellular component organization and biogenesis | 0.0322924246582231 |
| GO:0046928 | regulation of neurotransmitter secretion | 0.0331948016188894 |
| GO:0000287 | magnesium ion binding | 0.033542425398795 |
| GO:0031032 | actomyosin structure organization and biogenesis | 0.033542425398795 |
| GO:0043283 | biopolymer metabolic process | 0.0341104962285092 |
| GO:0048628 | myoblast maturation | 0.0355483301374609 |
| GO:0048627 | myoblast development | 0.0361768257488923 |
| GO:0005524 | ATP binding | 0.0361768257488923 |
| GO:0005884 | actin filament | 0.0361768257488923 |
| GO:0043687 | post-translational protein modification | 0.0361768257488923 |
| GO:0032559 | adenyl ribonucleotide binding | 0.0361768257488923 |
| GO:0000082 | G1/S transition of mitotic cell cycle | 0.0361768257488923 |
| GO:0030554 | adenyl nucleotide binding | 0.040082649846084 |
| GO:0044260 | cellular macromolecule metabolic process | 0.0406249937616477 |
| GO:0051146 | striated muscle cell differentiation | 0.0407477437389256 |
| GO:0030018 | Z disc | 0.0407477437389256 |
| GO:0009790 | embryonic development | 0.0407477437389256 |
| GO:0007010 | cytoskeleton organization and biogenesis | 0.0407477437389256 |
| GO:0006073 | glucan metabolic process | 0.0407477437389256 |
| GO:0005977 | glycogen metabolic process | 0.0407477437389256 |
| GO:0046777 | protein amino acid autophosphorylation | 0.0419774434292199 |
| GO:0003007 | heart morphogenesis | 0.0419774434292199 |
| GO:0031674 | I band | 0.0419774434292199 |
| GO:0006464 | protein modification process | 0.0419774434292199 |
| GO:0006112 | energy reserve metabolic process | 0.0419774434292199 |
| GO:0016540 | protein autoprocessing | 0.0419774434292199 |
| GO:0045445 | myoblast differentiation | 0.0425529965167711 |
| GO:0006338 | chromatin remodeling | 0.0431119552158971 |
| GO:0043412 | biopolymer modification | 0.0445802755995821 |
| GO:0005515 | protein binding | 0.0446004509426013 |
| GO:0044430 | cytoskeletal part | 0.0446004509426013 |
| GO:0051325 | interphase | 0.0446004509426013 |
| GO:0051329 | interphase of mitotic cell cycle | 0.0446004509426013 |
| GO:0032553 | ribonucleotide binding | 0.0459119732619108 |
| GO:0032555 | purine ribonucleotide binding | 0.0459119732619108 |
| GO:0043234 | protein complex | 0.0459119732619108 |
| GO:0004702 | receptor signaling protein serine/threonine kinase activity | 0.0473396445133648 |
| GO:0005976 | polysaccharide metabolic process | 0.0473396445133648 |
| GO:0044264 | cellular polysaccharide metabolic process | 0.0473396445133648 |
| GO:0017076 | purine nucleotide binding | 0.0482796740743974 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| primary circulatory organ | 3.57e-16 | 18 |
| heart | 3.57e-16 | 18 |
| primitive heart tube | 3.57e-16 | 18 |
| primary heart field | 3.57e-16 | 18 |
| anterior lateral plate mesoderm | 3.57e-16 | 18 |
| heart tube | 3.57e-16 | 18 |
| heart primordium | 3.57e-16 | 18 |
| cardiac mesoderm | 3.57e-16 | 18 |
| cardiogenic plate | 3.57e-16 | 18 |
| heart rudiment | 3.57e-16 | 18 |
| cardiovascular system | 1.40e-11 | 23 |
| circulatory system | 1.40e-11 | 23 |
| splanchnic layer of lateral plate mesoderm | 1.22e-07 | 33 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
