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Coexpression cluster:C241

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Full id: C241_Reticulocytes_chronic_Tracheal_Hodgkin_Endothelial_Hair_thymus



Phase1 CAGE Peaks

Hg19::chr1:149858227..149858237,-p1@HIST2H2BE
Hg19::chr1:149858461..149858479,+p1@BOLA1
Hg19::chr1:149859507..149859521,-p1@HIST2H2AB
Hg19::chr6:26020672..26020689,+p10@HIST1H3A
p10@HIST1H3B
p10@HIST1H3C
p10@HIST1H3D
p10@HIST1H3E
p10@HIST1H3F
p10@HIST1H3G
p10@HIST1H3I
p10@HIST1H3J
p11@HIST1H3H
Hg19::chr6:26021869..26021887,+p8@HIST1H4A
p8@HIST1H4B
p8@HIST1H4D
p8@HIST1H4E
p8@HIST1H4H
p8@HIST1H4I
p8@HIST1H4J
p8@HIST1H4K
p8@HIST1H4L
p8@HIST2H4A
p8@HIST2H4B
p8@HIST4H4
p9@HIST1H4C
p9@HIST1H4F
Hg19::chr6:26027503..26027522,-p2@HIST1H4A
p2@HIST1H4B
p2@HIST1H4D
p2@HIST1H4E
p2@HIST1H4F
p2@HIST1H4H
p2@HIST1H4I
p2@HIST1H4J
p2@HIST1H4K
p2@HIST1H4L
p2@HIST2H4A
p2@HIST2H4B
p2@HIST4H4
p3@HIST1H4C
Hg19::chr6:26032319..26032337,-p1@HIST1H3A
p1@HIST1H3B
p1@HIST1H3C
p1@HIST1H3D
p1@HIST1H3E
p1@HIST1H3F
p1@HIST1H3G
p1@HIST1H3H
p1@HIST1H3I
p1@HIST1H3J
Hg19::chr6:26033837..26033852,-p1@HIST1H2AB
p2@HIST1H2AE
Hg19::chr6:26043932..26043947,-p1@HIST1H2BB
Hg19::chr6:26045603..26045639,+p2@HIST1H3A
p2@HIST1H3B
p2@HIST1H3C
p2@HIST1H3D
p2@HIST1H3E
p2@HIST1H3F
p2@HIST1H3G
p2@HIST1H3I
p2@HIST1H3J
p3@HIST1H3H
Hg19::chr6:26045645..26045670,+p12@HIST1H3C
Hg19::chr6:26045671..26045688,+p13@HIST1H3C
Hg19::chr6:26056695..26056701,-p1@HIST1H1C
Hg19::chr6:26104154..26104169,+p1@HIST1H4C
Hg19::chr6:26124147..26124168,-p1@HIST1H2BC
p1@HIST1H2BE
p1@HIST1H2BF
p1@HIST1H2BG
p1@HIST1H2BI
Hg19::chr6:26124393..26124422,+p1@HIST1H2AC
Hg19::chr6:26156551..26156564,+p1@HIST1H1E
Hg19::chr6:26158343..26158366,+p1@HIST1H2BD
Hg19::chr6:26183977..26184005,+p5@HIST1H2BE
Hg19::chr6:26189331..26189346,-p3@HIST1H4A
p3@HIST1H4B
p3@HIST1H4D
p3@HIST1H4E
p3@HIST1H4F
p3@HIST1H4H
p3@HIST1H4I
p3@HIST1H4J
p3@HIST1H4K
p3@HIST1H4L
p3@HIST2H4A
p3@HIST2H4B
p3@HIST4H4
p4@HIST1H4C
Hg19::chr6:26197500..26197521,-p10@HIST1H3H
p9@HIST1H3A
p9@HIST1H3B
p9@HIST1H3C
p9@HIST1H3D
p9@HIST1H3E
p9@HIST1H3F
p9@HIST1H3G
p9@HIST1H3I
p9@HIST1H3J
Hg19::chr6:26199499..26199528,-p3@HIST1H3A
p3@HIST1H3B
p3@HIST1H3C
p3@HIST1H3D
p3@HIST1H3E
p3@HIST1H3F
p3@HIST1H3G
p3@HIST1H3I
p3@HIST1H3J
p4@HIST1H3H
Hg19::chr6:26199709..26199720,+p5@HIST1H2BC
p5@HIST1H2BF
p5@HIST1H2BG
p5@HIST1H2BI
p6@HIST1H2BE
Hg19::chr6:26199737..26199754,+p2@HIST1H2BC
p2@HIST1H2BE
p2@HIST1H2BF
p2@HIST1H2BG
p2@HIST1H2BI
Hg19::chr6:26204825..26204845,+p1@HIST1H4A
p1@HIST1H4B
p1@HIST1H4D
p1@HIST1H4E
p1@HIST1H4F
p1@HIST1H4H
p1@HIST1H4I
p1@HIST1H4J
p1@HIST1H4K
p1@HIST1H4L
p1@HIST2H4A
p1@HIST2H4B
p1@HIST4H4
p2@HIST1H4C
Hg19::chr6:26216901..26216926,-p4@HIST1H2BC
p4@HIST1H2BE
p4@HIST1H2BF
p4@HIST1H2BG
p4@HIST1H2BI
Hg19::chr6:26217140..26217155,+p1@HIST1H2AE
Hg19::chr6:26217159..26217170,+p2@HIST1H2AB
p3@HIST1H2AE
Hg19::chr6:26235206..26235224,-p1@HIST1H1D
Hg19::chr6:26250853..26250874,-p7@HIST1H3A
p7@HIST1H3B
p7@HIST1H3C
p7@HIST1H3D
p7@HIST1H3E
p7@HIST1H3F
p7@HIST1H3G
p7@HIST1H3I
p7@HIST1H3J
p8@HIST1H3H
Hg19::chr6:26251822..26251833,+p2@HIST1H2BH
Hg19::chr6:26251835..26251848,+p1@HIST1H2BH
Hg19::chr6:26251938..26251963,+p4@HIST1H2BH
Hg19::chr6:26271633..26271648,-p8@HIST1H3A
p8@HIST1H3B
p8@HIST1H3C
p8@HIST1H3D
p8@HIST1H3E
p8@HIST1H3F
p8@HIST1H3G
p8@HIST1H3I
p8@HIST1H3J
p9@HIST1H3H
Hg19::chr6:26273152..26273175,+p3@HIST1H2BC
p3@HIST1H2BE
p3@HIST1H2BF
p3@HIST1H2BG
p3@HIST1H2BI
Hg19::chr6:26285754..26285769,-p4@HIST1H4A
p4@HIST1H4B
p4@HIST1H4D
p4@HIST1H4E
p4@HIST1H4F
p4@HIST1H4H
p4@HIST1H4I
p4@HIST1H4J
p4@HIST1H4K
p4@HIST1H4L
p4@HIST2H4A
p4@HIST2H4B
p4@HIST4H4
p5@HIST1H4C
Hg19::chr6:27100565..27100582,-p1@HIST1H2BJ
Hg19::chr6:27100811..27100830,+p2@HIST1H2AG
Hg19::chr6:27107053..27107068,+p6@HIST1H4A
p6@HIST1H4B
p6@HIST1H4D
p6@HIST1H4E
p6@HIST1H4F
p6@HIST1H4H
p6@HIST1H4I
p6@HIST1H4J
p6@HIST1H4K
p6@HIST1H4L
p6@HIST2H4A
p6@HIST2H4B
p6@HIST4H4
p7@HIST1H4C
Hg19::chr6:27114620..27114642,-p1@HIST1H2BK
Hg19::chr6:27114873..27114896,+p2@HIST1H2AH
Hg19::chr6:27775694..27775714,-p1@HIST1H2BL
Hg19::chr6:27775943..27775958,+p2@HIST1H2AI
p2@HIST1H3H
Hg19::chr6:27777819..27777836,+p6@HIST1H3A
p6@HIST1H3B
p6@HIST1H3C
p6@HIST1H3D
p6@HIST1H3E
p6@HIST1H3F
p6@HIST1H3G
p6@HIST1H3I
p6@HIST1H3J
p7@HIST1H3H
Hg19::chr6:27782128..27782154,+p@chr6:27782128..27782154
+
Hg19::chr6:27782548..27782562,-p1@HIST1H2AJ
Hg19::chr6:27782788..27782823,+p1@HIST1H2BM
Hg19::chr6:27806140..27806160,-p2@HIST1H2AK
p2@HIST1H2AM
p3@HIST1H2AG
p3@HIST1H2AH
p3@HIST1H2AI
p3@HIST1H2AL
Hg19::chr6:27806319..27806356,+p1@HIST1H2BN
Hg19::chr6:27833087..27833103,+p2@HIST1H2AL
Hg19::chr6:27835357..27835375,-p1@HIST1H1B
Hg19::chr6:27840112..27840133,-p4@HIST1H3A
p4@HIST1H3B
p4@HIST1H3C
p4@HIST1H3D
p4@HIST1H3E
p4@HIST1H3F
p4@HIST1H3G
p4@HIST1H3I
p4@HIST1H3J
p5@HIST1H3H
Hg19::chr6:27841303..27841318,-p5@HIST1H4A
p5@HIST1H4B
p5@HIST1H4D
p5@HIST1H4E
p5@HIST1H4F
p5@HIST1H4H
p5@HIST1H4I
p5@HIST1H4J
p5@HIST1H4K
p5@HIST1H4L
p5@HIST2H4A
p5@HIST2H4B
p5@HIST4H4
p6@HIST1H4C
Hg19::chr6:27858597..27858611,-p5@HIST1H3A
p5@HIST1H3B
p5@HIST1H3C
p5@HIST1H3D
p5@HIST1H3E
p5@HIST1H3F
p5@HIST1H3G
p5@HIST1H3I
p5@HIST1H3J
p6@HIST1H3H
Hg19::chr6:27860929..27860940,-p3@HIST1H2AK
p3@HIST1H2AM
p4@HIST1H2AG
p4@HIST1H2AH
p4@HIST1H2AI
p4@HIST1H2AL
Hg19::chr6:27860956..27860973,-p1@HIST1H2AG
p1@HIST1H2AH
p1@HIST1H2AI
p1@HIST1H2AK
p1@HIST1H2AL
p1@HIST1H2AM
Hg19::chr6:27861190..27861217,+p1@HIST1H2BO


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
5.99867518672387e-433.79716139319621e-4020138Systemic lupus erythematosus (KEGG):05322
5.63622937924873e-218.91933299266112e-1912168Transcription (Reactome):REACT_1788
7.84918119551512e-060.0008280886161268464147Apoptosis (Reactome):REACT_578
3.04922576076662e-256.43386635521756e-231277Chromosome Maintenance (Reactome):REACT_22172
1.73801363727582e-072.20032526479119e-056295IL-2 down reg. targets (Netpath):NetPath_14
6.65759954444847e-050.00602037215947983214{HIST3H3,14} (Static Module):NA
3.75950083391575e-261.18988201393433e-231023{NAP1L1,23} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0000786nucleosome1.87240583009347e-47
GO:0006334nucleosome assembly1.24319715022904e-43
GO:0031497chromatin assembly8.59066900014577e-43
GO:0006333chromatin assembly or disassembly1.68503280504556e-40
GO:0065004protein-DNA complex assembly2.63900901022237e-40
GO:0000785chromatin3.40333775091688e-39
GO:0006325establishment and/or maintenance of chromatin architecture2.79277149428791e-36
GO:0006323DNA packaging3.20258264069125e-36
GO:0044427chromosomal part4.05997084508814e-36
GO:0005694chromosome6.27988319008739e-35
GO:0051276chromosome organization and biogenesis6.27988319008739e-35
GO:0065003macromolecular complex assembly6.17057389922228e-32
GO:0022607cellular component assembly2.47748302547154e-31
GO:0006259DNA metabolic process1.3234334413781e-27
GO:0006996organelle organization and biogenesis6.92115581620494e-26
GO:0043234protein complex2.21798198387936e-20
GO:0043232intracellular non-membrane-bound organelle2.54356941516884e-20
GO:0043228non-membrane-bound organelle2.54356941516884e-20
GO:0016043cellular component organization and biogenesis2.41082496854606e-19
GO:0003677DNA binding8.81390916446168e-19
GO:0032991macromolecular complex6.43074720407152e-18
GO:0044446intracellular organelle part1.9981622722602e-17
GO:0044422organelle part2.0058261240859e-17
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process1.93426613118056e-14
GO:0005634nucleus3.73806364802859e-14
GO:0003676nucleic acid binding9.93882761845355e-14
GO:0043231intracellular membrane-bound organelle5.09762757670053e-12
GO:0043227membrane-bound organelle5.09762757670053e-12
GO:0043283biopolymer metabolic process6.80345903204537e-12
GO:0043229intracellular organelle2.82945618182235e-09
GO:0043226organelle2.82945618182235e-09
GO:0016584nucleosome positioning3.30511061749485e-09
GO:0043170macromolecule metabolic process7.1455221981178e-09
GO:0044237cellular metabolic process2.11542148816235e-07
GO:0044238primary metabolic process2.48135321557574e-07
GO:0044424intracellular part3.50192310313866e-07
GO:0005622intracellular8.50752770264734e-06
GO:0042742defense response to bacterium3.71707117147414e-05
GO:0009617response to bacterium5.02592023955664e-05
GO:0051707response to other organism0.000350500324494739
GO:0009607response to biotic stimulus0.000917422283520578
GO:0051704multi-organism process0.00134820086403117
GO:0006952defense response0.00645472099872346
GO:0044464cell part0.00693752947648842



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>


Cell Type
Ontology termp-valuen
animal cell3.91e-13679
eukaryotic cell3.91e-13679
native cell5.82e-12722
embryonic cell7.93e-10248
somatic cell6.81e-09591
lymphocyte4.24e-0753
common lymphoid progenitor4.24e-0753
lymphoid lineage restricted progenitor cell8.75e-0752
Disease
Ontology termp-valuen
hematologic cancer9.27e-1751
immune system cancer9.27e-1751
leukemia1.22e-1339
myeloid leukemia5.90e-1031
cancer1.66e-09235
disease of cellular proliferation9.93e-09239
organ system cancer9.53e-07137


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#5333573.483968170618410.003807134786115380.018805020333291
BCL3#6023621.81922282341374.34006651449099e-412.54647307138721e-38
BCLAF1#97743914.81496941745181.02890897892466e-385.68562036242924e-36
BRCA1#672248.49862342872587.04514769369977e-171.43149451358426e-14
CCNT2#905343.779488659942626.28480958565441e-141.00826302352713e-11
CEBPB#1051334.6148749412675.86154552284297e-161.12531976628713e-13
CHD2#1106356.351592968317371.1886081975187e-213.23273571720456e-19
E2F1#1869423.61597100043747.53542935178761e-181.63956813764864e-15
E2F4#1874378.223126871324993.73016297821215e-271.30729695060905e-24
E2F6#1876322.816648831830111.79885789256083e-091.56038969635515e-07
EBF1#1879142.187553260560810.003558468571277490.0180374150221146
EGR1#1958312.712869332265161.04457479505872e-087.88823911938809e-07
ELF1#1997463.436359756230641.17115945785052e-192.8984531426173e-17
ELK4#2005102.848365203240.002340426273766080.0132677511591953
EP300#2033495.823213062893638.8922482414325e-334.00300652623693e-30
ETS1#2113386.485840614801562.37109841958564e-247.30487161779071e-22
FOS#2353467.261507793142856.41389165691216e-343.00385843388453e-31
FOSL1#806174.877106280958090.0005612791076017450.0047899516848193
FOSL2#2355133.861273822093022.20978727127627e-050.000484035177904409
FOXA1#3169203.888217455924725.62788235184651e-083.52591724621774e-06
FOXA2#3170125.185360790034792.55263336015647e-068.9822936489684e-05
GABPB1#2553161.983911252261660.00462492922581420.0218414191008279
GATA1#2623337.850704714831835.29863065004885e-231.5457644873197e-20
GATA2#2624204.471905871422455.35856617946625e-094.28517069844775e-07
GATA3#262583.822668962414880.001090731674018730.0076258485274362
GTF2B#29594525.21881310604548.3015813244955e-577.10662993400808e-54
GTF2F1#29625311.84564958716067.02103988624866e-545.6405414206148e-51
HEY1#23462543.827473619784362.23089890309063e-298.66144425798819e-27
HMGN3#9324233.300115748018667.92257646547208e-084.7389803177402e-06
IRF1#3659354.689486515346262.15404262613805e-174.51739071950265e-15
IRF3#36614537.09101490380762.49402641125534e-642.45729834306695e-61
JUN#3725183.951419744948322.56899895276952e-071.33285485160604e-05
JUNB#372694.833257788392819.16875838797133e-050.00133571761372763
JUND#3727496.01295672195931.92549118794376e-338.85887110914792e-31
KAT2A#264814151.3203508771934.68419733121762e-271.62529197699348e-24
MAFK#797583.803611668467360.001126105067359590.007721197947083
MEF2A#420592.959457512049060.003062619745409180.0161478666998581
MEF2C#420896.52284544620388.91861022492198e-060.000240312366687468
MXI1#4601264.543874778030565.75583371556123e-127.45823222604838e-10
MYC#4609302.748569406110211.63918086946744e-081.18967623923773e-06
NFKB1#4790555.295499795274752.22996736899318e-381.2067127567372e-35
NFYA#48003912.60697626830514.86097602747369e-362.47646573333329e-33
NFYB#4801349.99706966000423.05366060837617e-271.0810890178922e-24
NRF1#4899142.999016004700920.0001582844446524690.00199481949017246
PAX5#5079323.744317491187558.29467660754785e-131.17702137257567e-10
PBX3#5090269.996093506234164.06887158578937e-201.0415413714418e-17
POLR2A#5430572.147453176558071.19136376157406e-192.94148557671474e-17
POU2F2#5452579.106124057742521.93890343033548e-551.61997708288646e-52
POU5F1#5460211.76979654217210.01270532038883970.0458384329173011
PRDM1#63936.938471356708460.009400443239007160.0354699552526706
RDBP#79362978.16690729317063.52270968847638e-482.43647865665421e-45
REST#5978467.787742472664722.79928828858637e-351.38556810223541e-32
RFX5#5993428.877407977933232.36450442593599e-331.08309858658039e-30
RXRA#6256207.043725311976591.75258815348806e-122.40208076328267e-10
SETDB1#9869128.488426563791681.34028923477529e-089.86458543979537e-07
SIN3A#25942524.934421154287491.12879048385946e-325.0380234762307e-30
SMARCB1#659892.882007754919590.003650652333961990.01843935189373
SP1#6667565.598409775015622.16133187818758e-411.27529570636176e-38
SREBF1#672054.123320126358620.007282087574151320.0301297022485061
SRF#6722194.59905942072269.36780721169492e-097.14656258131633e-07
STAT2#677355.72489220933690.001820387176662330.0108957198890158
STAT3#6774274.982904472336221.98202226204488e-133.00000613080732e-11
TAF1#6872563.284396350907661.75559913207631e-286.45609217446894e-26
TAF7#68795310.63074874492932.11216857080828e-511.58699836954421e-48
TBP#6908563.641739622410485.60667282508411e-312.31444783865201e-28
TCF12#6938509.328477984374055.82767963345609e-443.68870929235467e-41
WRNIP1#568971121.19332645338844.34782803891637e-125.72613887208558e-10
YY1#7528484.135722736719047.91839839057802e-252.49845803478422e-22
ZBTB33#100094122.77638116191639.20018126289841e-496.49228196564762e-46
ZEB1#6935319.184936711295782.23736491997322e-236.73395259011765e-21



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data