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CL:0000057

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Name:fibroblast
Namespace:cell;;efo
Definition:"A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." ISBN:0517223651, MESH:A.11.329.228
Xrefs:
links:

BTO:0000452

FMA:63877
Comments:These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0002320(connective tissue cell)
develops_from:CL:0000134(mesenchymal cell)



Children


is a:CL:0000005 (fibroblast neural crest derived),CL:0000632 (hepatic stellate cell),CL:0002334 (preadipocyte),CL:0002548 (cardiac fibroblast),CL:0002549 (fibroblast of choroid plexus),CL:0002550 (fibroblast of the conjuctiva),CL:0002552 (fibroblast of gingiva),CL:0002553 (lung fibroblast),CL:0002554 (fibroblast of lymphatic vessel),CL:0002555 (fibroblast of mammary gland),CL:0002556 (fibroblast of periodontium),CL:0002557 (fibroblast of pulmonary artery),CL:0002558 (fibroblast of villous mesenchyme),CL:0002620 (skin fibroblast),CL:1000306 (fibroblast of tunica adventitia of artery)
derives from:FF:0000057 (fibroblast sample),FF:0000107 (mouse embryonic fibroblast sample),FF:0100453 (fibroblast cell line sample)
develops from:CL:0000135 (fibrocyte)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000057 (fibroblast), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.07e-86FFCP PHASE1:Mm9::chr2:156282978..156282979,+#_b3a45416708d7941f5fd9feda8878cf3p@chr2:156282978..156282979, +
3.07e-86FFCP PHASE2:Mm9::chrX:45409736..45409738,+#_b3a45416708d7941f5fd9feda8878cf3p@chrX:45409736..45409738, +
3.07e-86FFCP PHASE2:Mm9::chr10:94173889..94173890,-#_b3a45416708d7941f5fd9feda8878cf3p@chr10:94173889..94173890, -
3.07e-86FFCP PHASE1:Mm9::chr4:50498164..50498166,+#_b3a45416708d7941f5fd9feda8878cf3p@chr4:50498164..50498166, +
3.07e-86FFCP PHASE1:Mm9::chr10:94173889..94173890,-#_b3a45416708d7941f5fd9feda8878cf3p@chr10:94173889..94173890, -
3.07e-86FFCP PHASE1:Mm9::chr4:61715146..61715151,-#_b3a45416708d7941f5fd9feda8878cf3p1@Mup20
3.07e-86FFCP PHASE2:Mm9::chr17:15914532..15914535,+#_b3a45416708d7941f5fd9feda8878cf3p@chr17:15914532..15914535, +
3.07e-86FFCP PHASE2:Mm9::chr4:50498164..50498166,+#_b3a45416708d7941f5fd9feda8878cf3p@chr4:50498164..50498166, +
3.07e-86FFCP PHASE1:Mm9::chrX:45409736..45409738,+#_b3a45416708d7941f5fd9feda8878cf3p@chrX:45409736..45409738, +
3.07e-86FFCP PHASE2:Mm9::chr4:61715146..61715151,-#_b3a45416708d7941f5fd9feda8878cf3p1@Mup20
3.07e-86FFCP PHASE2:Mm9::chr2:156282978..156282979,+#_b3a45416708d7941f5fd9feda8878cf3p@chr2:156282978..156282979, +
3.07e-86FFCP PHASE1:Mm9::chr17:15914532..15914535,+#_b3a45416708d7941f5fd9feda8878cf3p@chr17:15914532..15914535, +
8.69e-51FFCP PHASE1:Hg19::chr14:92413727..92413738,-#_652b2b5d8eeceb5aa07b63a8f14b7540p7@FBLN5
8.69e-51FFCP PHASE2:Hg19::chr14:92413727..92413738,-#_652b2b5d8eeceb5aa07b63a8f14b7540p7@FBLN5
4.89e-45FFCP PHASE1:Hg19::chr1:161167199..161167216,+#_2f5eb83338e022f6601eab4dc43b5c2bp2@NDUFS2
4.89e-45FFCP PHASE2:Hg19::chr1:161167199..161167216,+#_2f5eb83338e022f6601eab4dc43b5c2bp2@NDUFS2
8.65e-45FFCP PHASE2:Hg19::chr15:80842610..80842647,-#_6316da597d2c1f5fb15d60f3b7f2a43ap@chr15:80842610..80842647, -
8.65e-45FFCP PHASE1:Hg19::chr15:80842610..80842647,-#_6316da597d2c1f5fb15d60f3b7f2a43ap@chr15:80842610..80842647, -
8.96e-45FFCP PHASE1:Hg19::chr1:240408577..240408596,+#_6f500911c77d07461f3034c8ac5aafc3p4@FMN2
8.96e-45FFCP PHASE2:Hg19::chr1:240408577..240408596,+#_6f500911c77d07461f3034c8ac5aafc3p4@FMN2
4.22e-44FFCP PHASE2:Hg19::chr6:148593425..148593498,+#_9d2ffcdd1a3e9ec1ad43bfc0ff70c447p2@SASH1
4.22e-44FFCP PHASE1:Hg19::chr6:148593425..148593498,+#_9d2ffcdd1a3e9ec1ad43bfc0ff70c447p2@SASH1
7.47e-44FFCP PHASE2:Mm9::chr7:111614187..111614200,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:111614187..111614200, +
7.47e-44FFCP PHASE2:Mm9::chr3:127483562..127483571,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr3:127483562..127483571, +
7.47e-44FFCP PHASE2:Mm9::chr18:38702532..38702560,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr18:38702532..38702560, +
7.47e-44FFCP PHASE1:Mm9::chr3:127483562..127483571,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr3:127483562..127483571, +
7.47e-44FFCP PHASE2:Mm9::chr11:48686060..48686062,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr11:48686060..48686062, +
7.47e-44FFCP PHASE1:Mm9::chr7:129965112..129965151,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:129965112..129965151, +
7.47e-44FFCP PHASE1:Mm9::chr2:35991779..35991800,-#_4b9eb53154bfec94f8733d365a8d12a9p7@Rbm18
7.47e-44FFCP PHASE1:Mm9::chr19:39390004..39390011,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr19:39390004..39390011, +
7.47e-44FFCP PHASE1:Mm9::chr8:42092122..42092137,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr8:42092122..42092137, -
7.47e-44FFCP PHASE2:Mm9::chrX:166354085..166354088,+#_4b9eb53154bfec94f8733d365a8d12a9p@chrX:166354085..166354088, +
7.47e-44FFCP PHASE2:Mm9::chr2:35991779..35991800,-#_4b9eb53154bfec94f8733d365a8d12a9p7@Rbm18
7.47e-44FFCP PHASE2:Mm9::chr6:31268117..31268151,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr6:31268117..31268151, -
7.47e-44FFCP PHASE1:Mm9::chr5:114824802..114824807,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr5:114824802..114824807, +
7.47e-44FFCP PHASE2:Mm9::chr8:42092122..42092137,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr8:42092122..42092137, -
7.47e-44FFCP PHASE1:Mm9::chr18:38702532..38702560,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr18:38702532..38702560, +
7.47e-44FFCP PHASE1:Mm9::chr11:48686060..48686062,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr11:48686060..48686062, +
7.47e-44FFCP PHASE2:Mm9::chr5:114824802..114824807,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr5:114824802..114824807, +
7.47e-44FFCP PHASE2:Mm9::chr19:39390004..39390011,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr19:39390004..39390011, +
7.47e-44FFCP PHASE2:Mm9::chr7:129965112..129965151,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:129965112..129965151, +
7.47e-44FFCP PHASE1:Mm9::chr7:111614187..111614200,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:111614187..111614200, +
7.47e-44FFCP PHASE1:Mm9::chr6:31268117..31268151,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr6:31268117..31268151, -
7.47e-44FFCP PHASE1:Mm9::chrX:166354085..166354088,+#_4b9eb53154bfec94f8733d365a8d12a9p@chrX:166354085..166354088, +
2.51e-41FFCP PHASE1:Hg19::chr15:33180498..33180522,-#_223331b813e745267822e9a9d8348dc0p4@FMN1
2.51e-41FFCP PHASE2:Hg19::chr15:33180498..33180522,-#_223331b813e745267822e9a9d8348dc0p4@FMN1
7.15e-41FFCP PHASE1:Hg19::chr14:92413677..92413688,-#_bfa6fb5186e986a4156db62616986005p12@FBLN5
7.15e-41FFCP PHASE2:Hg19::chr14:92413677..92413688,-#_bfa6fb5186e986a4156db62616986005p12@FBLN5
8.81e-41FFCP PHASE1:Hg19::chr1:215179028..215179060,+#_31f0fa2f6fe51571be4070c31c781a7dp9@KCNK2
8.81e-41FFCP PHASE2:Hg19::chr1:215179028..215179060,+#_31f0fa2f6fe51571be4070c31c781a7dp9@KCNK2
3.67e-40FFCP PHASE1:Hg19::chr1:215178636..215178662,+#_9283ec5782d941e7579bf126f7d62d3ep5@KCNK2
3.67e-40FFCP PHASE2:Hg19::chr1:215178636..215178662,+#_9283ec5782d941e7579bf126f7d62d3ep5@KCNK2
4.28e-38FFCP PHASE1:Hg19::chr19:10928326..10928342,-#_f6e700b9aee4b1563bdd0fe0360c6ac8p1@MIR199A1
4.28e-38FFCP PHASE2:Hg19::chr19:10928326..10928342,-#_f6e700b9aee4b1563bdd0fe0360c6ac8p1@MIR199A1
6.13e-38FFCP PHASE1:Hg19::chr18:52969844..52969895,-#_5ce9506676de1d63c543c4032228d6d6p27@TCF4
6.13e-38FFCP PHASE2:Hg19::chr18:52969844..52969895,-#_5ce9506676de1d63c543c4032228d6d6p27@TCF4
1.61e-37FFCP PHASE1:Hg19::chr15:81201549..81201567,+#_50583cd4c438ca9abe78181fe26a438fp2@KIAA1199
1.61e-37FFCP PHASE2:Hg19::chr15:81201549..81201567,+#_50583cd4c438ca9abe78181fe26a438fp2@KIAA1199
2.86e-37FFCP PHASE1:Hg19::chr12:78334695..78334719,+#_c4e272da707ff320324de8bf7bb90388p@chr12:78334695..78334719, +
2.86e-37FFCP PHASE2:Hg19::chr12:78334695..78334719,+#_c4e272da707ff320324de8bf7bb90388p@chr12:78334695..78334719, +
4.22e-37FFCP PHASE1:Hg19::chr13:45289884..45289918,-#_6d5f155b5b500bb3b2168c4a42520658p@chr13:45289884..45289918, -
4.22e-37FFCP PHASE2:Hg19::chr13:45289884..45289918,-#_6d5f155b5b500bb3b2168c4a42520658p@chr13:45289884..45289918, -
6.18e-37FFCP PHASE2:Hg19::chr2:239756536..239756564,-#_45acdc479bc4426efea8a871454678efp1@BC143627
6.18e-37FFCP PHASE1:Hg19::chr2:239756536..239756564,-#_45acdc479bc4426efea8a871454678efp1@BC143627
6.63e-37FFCP PHASE1:Hg19::chr1:215178944..215178967,+#_674e775e220d0a8c4de58f42516654d7p11@KCNK2
6.63e-37FFCP PHASE2:Hg19::chr1:215178944..215178967,+#_674e775e220d0a8c4de58f42516654d7p11@KCNK2
6.76e-37FFCP PHASE1:Hg19::chr14:92413764..92413794,-#_76a3e271fc520aa8c9a22ea0cb99c519p2@FBLN5
6.76e-37FFCP PHASE2:Hg19::chr14:92413764..92413794,-#_76a3e271fc520aa8c9a22ea0cb99c519p2@FBLN5
1.13e-36FFCP PHASE2:Hg19::chr12:108991778..108991800,-#_31f1533ce9eaeed933486287845d2b19p2@TMEM119
1.13e-36FFCP PHASE1:Hg19::chr12:108991778..108991800,-#_31f1533ce9eaeed933486287845d2b19p2@TMEM119
1.92e-36FFCP PHASE2:Hg19::chr6:52441791..52441804,-#_514bb67a6e856f84efa086406221fc02p3@TRAM2
1.92e-36FFCP PHASE1:Hg19::chr6:52441791..52441804,-#_514bb67a6e856f84efa086406221fc02p3@TRAM2
3.45e-36FFCP PHASE2:Hg19::chr6:52441770..52441784,-#_1b8a4a599ed128c36fe0d6cae49ef512p2@TRAM2
3.45e-36FFCP PHASE1:Hg19::chr6:52441770..52441784,-#_1b8a4a599ed128c36fe0d6cae49ef512p2@TRAM2
4.74e-36FFCP PHASE1:Hg19::chr2:238322983..238323006,-#_3a32d70f20211eb08b0a7d38d336fc29p4@COL6A3
4.74e-36FFCP PHASE2:Hg19::chr2:238322983..238323006,-#_3a32d70f20211eb08b0a7d38d336fc29p4@COL6A3
5.54e-36FFCP PHASE1:Hg19::chr21:47518695..47518709,+#_d530f61b9a748918517003c9480626bap6@COL6A2
5.54e-36FFCP PHASE2:Hg19::chr21:47518695..47518709,+#_d530f61b9a748918517003c9480626bap6@COL6A2
1.05e-35FFCP PHASE1:Hg19::chr19:50031567..50031632,+#_125dc473df089cf4efe37ca0de76efa8p2@RCN3
1.05e-35FFCP PHASE2:Hg19::chr19:50031567..50031632,+#_125dc473df089cf4efe37ca0de76efa8p2@RCN3
2.16e-35FFCP PHASE1:Hg19::chr15:39410918..39410942,-#_b7861d091c45516728a2d7ae943b212ap1@ENST00000560197
2.16e-35FFCP PHASE2:Hg19::chr15:39410918..39410942,-#_b7861d091c45516728a2d7ae943b212ap1@ENST00000560197
2.63e-35FFCP PHASE1:Hg19::chr1:198636258..198636278,-#_914826195842a37f1825d32f0cc6639dp1@ENST00000413577
2.63e-35FFCP PHASE2:Hg19::chr1:198636258..198636278,-#_914826195842a37f1825d32f0cc6639dp1@ENST00000413577
3.83e-35FFCP PHASE2:Hg19::chr2:239756739..239756755,+#_de1acb1908db33af4757fb4c84aee10cp2@TWIST2
3.83e-35FFCP PHASE1:Hg19::chr2:239756739..239756755,+#_de1acb1908db33af4757fb4c84aee10cp2@TWIST2
6.05e-35FFCP PHASE2:Hg19::chr14:92413748..92413762,-#_3cf355da3268a924da3f621073a47d6ap1@FBLN5
6.05e-35FFCP PHASE1:Hg19::chr14:92413748..92413762,-#_3cf355da3268a924da3f621073a47d6ap1@FBLN5
7.69e-35FFCP PHASE1:Hg19::chr7:135433488..135433499,-#_26f051acefa60761b55e866e39ab9808p2@FAM180A
7.69e-35FFCP PHASE2:Hg19::chr7:135433488..135433499,-#_26f051acefa60761b55e866e39ab9808p2@FAM180A
8.37e-35FFCP PHASE2:Hg19::chr2:238289803..238289845,-#_23a23247f02f5503ea6c21917ed87422p@chr2:238289803..238289845, -
8.37e-35FFCP PHASE1:Hg19::chr2:238289803..238289845,-#_23a23247f02f5503ea6c21917ed87422p@chr2:238289803..238289845, -
1.04e-34FFCP PHASE1:Hg19::chr9:132461010..132461045,+#_2e24cf9d35dfe8c7fcab876885a1abe1p@chr9:132461010..132461045, +
1.04e-34FFCP PHASE2:Hg19::chr9:132461010..132461045,+#_2e24cf9d35dfe8c7fcab876885a1abe1p@chr9:132461010..132461045, +
1.22e-34FFCP PHASE2:Hg19::chr11:35547572..35547588,-#_456bb89cc8a0ecb1813d433e6a85f10ep3@PAMR1
1.22e-34FFCP PHASE1:Hg19::chr11:35547572..35547588,-#_456bb89cc8a0ecb1813d433e6a85f10ep3@PAMR1
1.75e-34FFCP PHASE2:Hg19::chr17:78808278..78808309,-#_8983870ba71748727843959ecc883884p@chr17:78808278..78808309, -
1.75e-34FFCP PHASE1:Hg19::chr17:78808278..78808309,-#_8983870ba71748727843959ecc883884p@chr17:78808278..78808309, -
1.82e-34FFCP PHASE2:Hg19::chr11:66082890..66082979,+#_61a74ab8cb62cb6c2739c8fd01724bbap@chr11:66082890..66082979, +
1.82e-34FFCP PHASE1:Hg19::chr11:66082890..66082979,+#_61a74ab8cb62cb6c2739c8fd01724bbap@chr11:66082890..66082979, +

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