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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=-0.141575908464105

Latest revision as of 11:29, 17 September 2013


Full id: C709_acute_synovial_oral_hepatocellular_testicular_small_gall



Phase1 CAGE Peaks

Hg19::chr2:99953983..99954001,+p2@EIF5B
Hg19::chr2:99976700..99976717,+p@chr2:99976700..99976717
+
Hg19::chr2:99976740..99976760,+p@chr2:99976740..99976760
+
Hg19::chr2:99976962..99976987,+p@chr2:99976962..99976987
+
Hg19::chr2:99977665..99977695,+p3@EIF5B
Hg19::chr2:99977750..99977764,+p7@EIF5B
Hg19::chr2:99977767..99977790,+p6@EIF5B
Hg19::chr2:99977910..99977931,+p8@EIF5B
Hg19::chr2:99977985..99978027,+p4@EIF5B
Hg19::chr2:99980846..99980859,+p@chr2:99980846..99980859
+
Hg19::chr2:99984948..99984969,+p@chr2:99984948..99984969
+
Hg19::chr2:99985014..99985027,+p@chr2:99985014..99985027
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br><br>disease_data<br>

Disease
Ontology termp-valuen
cancer1.06e-35235
disease of cellular proliferation1.22e-35239
cell type cancer1.31e-18143
organ system cancer1.09e-14137
carcinoma7.30e-14106
hematologic cancer7.14e-1251
immune system cancer7.14e-1251
leukemia8.81e-1039
myeloid leukemia3.12e-0731


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.14.86258e-05
MA0004.10.32225
MA0006.10.188769
MA0007.10.305951
MA0009.10.756202
MA0014.10.00141144
MA0017.10.220105
MA0019.10.45566
MA0024.10.654931
MA0025.10.886436
MA0027.12.35633
MA0028.10.201461
MA0029.10.673506
MA0030.10.662482
MA0031.12.48999
MA0038.10.414169
MA0040.10.67914
MA0041.10.89827
MA0042.10.310552
MA0043.10.756508
MA0046.10.745626
MA0048.10.0399193
MA0050.12.30599
MA0051.11.85986
MA0052.11.63439
MA0055.10.107116
MA0056.10
MA0057.10.0373953
MA0058.10.240796
MA0059.10.239727
MA0060.10.103131
MA0061.10.0856761
MA0063.10
MA0066.10.414559
MA0067.11.06751
MA0068.10.0633085
MA0069.10.741884
MA0070.10.731026
MA0071.10.379038
MA0072.10.726666
MA0073.11.33944e-06
MA0074.10.40963
MA0076.10.254045
MA0077.11.70983
MA0078.11.25378
MA0081.11.25193
MA0083.10.763502
MA0084.12.79852
MA0087.11.7204
MA0088.10.0806254
MA0089.10
MA0090.10.266215
MA0091.10.324543
MA0092.10.291716
MA0093.10.191154
MA0095.10
MA0098.10
MA0100.10.426863
MA0101.10.19375
MA0103.10.181541
MA0105.10.0320473
MA0106.10.452066
MA0107.10.137948
MA0108.20.597764
MA0109.10
MA0111.10.277713
MA0113.10.467266
MA0114.10.134281
MA0115.10.992167
MA0116.10.140463
MA0117.10.792789
MA0119.10.226505
MA0122.10.818044
MA0124.10.951337
MA0125.10.868909
MA0130.10
MA0131.10.519055
MA0132.10
MA0133.10
MA0135.10.785738
MA0136.10.420617
MA0139.10.0781324
MA0140.10.376643
MA0141.10.238287
MA0142.13.50531
MA0143.13.04423
MA0144.10.124153
MA0145.10.0212759
MA0146.10.000996775
MA0147.10.143012
MA0148.11.63103
MA0149.10.367947
MA0062.20.0823902
MA0035.20.981089
MA0039.27.40554e-05
MA0138.20.503176
MA0002.20.316618
MA0137.20.20663
MA0104.20.102626
MA0047.22.92258
MA0112.20.0859008
MA0065.20.096411
MA0150.10.261236
MA0151.10
MA0152.10.382565
MA0153.10.852412
MA0154.10.0310431
MA0155.10.0793743
MA0156.10.208455
MA0157.11.34413
MA0158.10
MA0159.10.441451
MA0160.10.357736
MA0161.10
MA0162.10.00310762
MA0163.10.00158421
MA0164.10.478818
MA0080.21.06373
MA0018.20.453345
MA0099.20.382887
MA0079.21.73671e-07
MA0102.21.28978
MA0258.10.117513
MA0259.10.149181
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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