MCL coexpression mm9:1428

Phase1 CAGE Peaks

	Short description
Mm9::chr1:52851770..52851774,-	p11@Inpp1
Mm9::chr2:74517609..74517621,+	p3@Hoxd11
Mm9::chr2:74518687..74518718,+	p@chr2:74518687..74518718 +
Mm9::chr2:74521950..74521958,+	p@chr2:74521950..74521958 +
Mm9::chr2:74524610..74524614,+	p@chr2:74524610..74524614 +
Mm9::chr6:52190760..52190767,-	p9@Hoxa10

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	0.00657426176518928
GO:0016312	inositol bisphosphate phosphatase activity	0.00657426176518928
GO:0007389	pattern specification process	0.0129813833085202
GO:0031403	lithium ion binding	0.0159556319171046
GO:0005667	transcription factor complex	0.0159556319171046
GO:0043565	sequence-specific DNA binding	0.0159556319171046
GO:0001759	induction of an organ	0.0159556319171046
GO:0010092	specification of organ identity	0.0159556319171046
GO:0009887	organ morphogenesis	0.0159556319171046
GO:0045168	cell-cell signaling during cell fate commitment	0.0159556319171046
GO:0031128	induction	0.0159556319171046
GO:0044451	nucleoplasm part	0.0159556319171046
GO:0005654	nucleoplasm	0.0161620160741983
GO:0031981	nuclear lumen	0.0211286186982944
GO:0031974	membrane-enclosed lumen	0.0231664287513844
GO:0043233	organelle lumen	0.0231664287513844
GO:0004437	inositol or phosphatidylinositol phosphatase activity	0.0231664287513844
GO:0003700	transcription factor activity	0.0250814589184038
GO:0001656	metanephros development	0.0310662268751669
GO:0044428	nuclear part	0.0328573178241881
GO:0009653	anatomical structure morphogenesis	0.0404475687807701
GO:0001822	kidney development	0.0434573076263936
GO:0001655	urogenital system development	0.0449695900056938
GO:0048513	organ development	0.0499652509385794

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
cavitated compound organ	1.10e-17	21
kidney	6.40e-15	14
kidney mesenchyme	6.40e-15	14
upper urinary tract	6.40e-15	14
kidney rudiment	6.40e-15	14
kidney field	6.40e-15	14
urinary system structure	1.41e-14	18
renal system	1.53e-13	19
forelimb	1.83e-09	7
pectoral appendage	1.83e-09	7
pectoral appendage bud	1.83e-09	7
forelimb bud	1.83e-09	7
forelimb/pectoral fin field	1.83e-09	7
pectoral complex	4.66e-08	8
reproductive structure	5.28e-07	26
reproductive system	5.28e-07	26
female reproductive system	8.85e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}