MCL coexpression mm9:1257

Phase1 CAGE Peaks

	Short description
Mm9::chr10:87322807..87322831,+	p19@Igf1
Mm9::chr15:103163786..103163821,-	p@chr15:103163786..103163821 -
Mm9::chr2:84371503..84371514,-	p3@ENSMUST00000139492
Mm9::chr6:122559982..122559997,-	p2@Gdf3
Mm9::chr9:124036273..124036323,+	p1@Ccr5
Mm9::chrX:20506928..20506955,-	p@chrX:20506928..20506955 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008083	growth factor activity	0.0163251889016673
GO:0005159	insulin-like growth factor receptor binding	0.0163251889016673
GO:0018445	prothoracicotrophic hormone activity	0.0163251889016673
GO:0033143	regulation of steroid hormone receptor signaling pathway	0.0174836080958784
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	0.0174836080958784
GO:0050654	chondroitin sulfate proteoglycan metabolic process	0.0174836080958784
GO:0030104	water homeostasis	0.0174836080958784
GO:0018987	osmoregulation	0.0174836080958784
GO:0021940	positive regulation of granule cell precursor proliferation	0.0174836080958784
GO:0021936	regulation of granule cell precursor proliferation	0.0174836080958784
GO:0048009	insulin-like growth factor receptor signaling pathway	0.0174836080958784
GO:0021534	cell proliferation in hindbrain	0.0174836080958784
GO:0021924	cell proliferation in the external granule layer	0.0174836080958784
GO:0021930	granule cell precursor proliferation	0.0174836080958784
GO:0030518	steroid hormone receptor signaling pathway	0.021128847713449
GO:0030166	proteoglycan biosynthetic process	0.021128847713449
GO:0019957	C-C chemokine binding	0.021128847713449
GO:0016493	C-C chemokine receptor activity	0.021128847713449
GO:0030522	intracellular receptor-mediated signaling pathway	0.021128847713449
GO:0005102	receptor binding	0.021128847713449
GO:0005184	neuropeptide hormone activity	0.021128847713449
GO:0006029	proteoglycan metabolic process	0.021128847713449
GO:0030879	mammary gland development	0.0233974392233283
GO:0004950	chemokine receptor activity	0.0235162858213455
GO:0019956	chemokine binding	0.0235162858213455
GO:0001637	G-protein chemoattractant receptor activity	0.0235162858213455
GO:0044272	sulfur compound biosynthetic process	0.0262628031664909
GO:0010001	glial cell differentiation	0.0331679118182337
GO:0042063	gliogenesis	0.0342078164785799
GO:0030902	hindbrain development	0.0342078164785799
GO:0048754	branching morphogenesis of a tube	0.0451191277470559
GO:0006790	sulfur metabolic process	0.0451191277470559
GO:0035264	multicellular organism growth	0.0451191277470559
GO:0001763	morphogenesis of a branching structure	0.0452229396790126
GO:0019955	cytokine binding	0.0467098664334941
GO:0050878	regulation of body fluid levels	0.0474379522898477
GO:0048732	gland development	0.0487826162142913
GO:0006916	anti-apoptosis	0.049394482355613
GO:0016051	carbohydrate biosynthetic process	0.049394482355613

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
bone marrow	3.79e-10	16
bone element	2.26e-09	22
skeletal element	2.26e-09	22
skeletal system	2.26e-09	22
hemolymphoid system	3.28e-09	48
immune system	3.28e-09	48
hematopoietic system	4.53e-09	45
blood island	4.53e-09	45
exocrine gland	4.49e-08	25
exocrine system	4.49e-08	25
musculoskeletal system	1.83e-07	32
foregut	2.32e-07	80
liver	4.57e-07	22
epithelial sac	4.57e-07	22
digestive gland	4.57e-07	22
epithelium of foregut-midgut junction	4.57e-07	22
anatomical boundary	4.57e-07	22
hepatobiliary system	4.57e-07	22
foregut-midgut junction	4.57e-07	22
hepatic diverticulum	4.57e-07	22
liver primordium	4.57e-07	22
septum transversum	4.57e-07	22
liver bud	4.57e-07	22

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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