MCL coexpression mm9:1225

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127080091..127080100,+	p4@Stat6
Mm9::chr11:22760432..22760456,-	p3@B3gnt2
Mm9::chr15:59480199..59480242,+	p1@Trib1
Mm9::chr5:32438831..32438878,+	p1@Fosl2
Mm9::chr5:32438894..32438908,+	p2@Fosl2
Mm9::chr6:125299825..125299838,+	p4@Tnfrsf1a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0048295	positive regulation of isotype switching to IgE isotypes	0.0151579902491918
GO:0002829	negative regulation of T-helper 2 type immune response	0.0151579902491918
GO:0002828	regulation of T-helper 2 type immune response	0.0151579902491918
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	0.0151579902491918
GO:0048289	isotype switching to IgE isotypes	0.0151579902491918
GO:0043120	tumor necrosis factor binding	0.0151579902491918
GO:0048293	regulation of isotype switching to IgE isotypes	0.0151579902491918
GO:0005031	tumor necrosis factor receptor activity	0.0151579902491918
GO:0045893	positive regulation of transcription, DNA-dependent	0.0151579902491918
GO:0002820	negative regulation of adaptive immune response	0.0151579902491918
GO:0005035	death receptor activity	0.0151579902491918
GO:0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0151579902491918
GO:0050777	negative regulation of immune response	0.0151579902491918
GO:0002683	negative regulation of immune system process	0.0151579902491918
GO:0042092	T-helper 2 type immune response	0.0151579902491918
GO:0045941	positive regulation of transcription	0.0151579902491918
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0151579902491918
GO:0045830	positive regulation of isotype switching	0.0194908236070853
GO:0031325	positive regulation of cellular metabolic process	0.0195423438037034
GO:0009893	positive regulation of metabolic process	0.0195423438037034
GO:0043283	biopolymer metabolic process	0.0195423438037034
GO:0006357	regulation of transcription from RNA polymerase II promoter	0.0195423438037034
GO:0045191	regulation of isotype switching	0.0195423438037034
GO:0006693	prostaglandin metabolic process	0.0195423438037034
GO:0006692	prostanoid metabolic process	0.0195423438037034
GO:0006366	transcription from RNA polymerase II promoter	0.0195423438037034
GO:0043565	sequence-specific DNA binding	0.0195423438037034
GO:0006355	regulation of transcription, DNA-dependent	0.0195423438037034
GO:0006351	transcription, DNA-dependent	0.0195423438037034
GO:0032774	RNA biosynthetic process	0.0195423438037034
GO:0050729	positive regulation of inflammatory response	0.0195423438037034
GO:0031349	positive regulation of defense response	0.0195423438037034
GO:0045449	regulation of transcription	0.0195423438037034
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0195423438037034
GO:0004860	protein kinase inhibitor activity	0.0195423438037034
GO:0006350	transcription	0.0195423438037034
GO:0002208	somatic diversification of immunoglobulins during immune response	0.0195423438037034
GO:0002204	somatic recombination of immunoglobulin genes during immune response	0.0195423438037034
GO:0045190	isotype switching	0.0195423438037034
GO:0002381	immunoglobulin production during immune response	0.0195423438037034
GO:0019210	kinase inhibitor activity	0.0195423438037034
GO:0002819	regulation of adaptive immune response	0.0195423438037034
GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	0.0195423438037034
GO:0010468	regulation of gene expression	0.0195423438037034
GO:0031323	regulation of cellular metabolic process	0.0208470082702882
GO:0050871	positive regulation of B cell activation	0.0208470082702882
GO:0016447	somatic recombination of immunoglobulin gene segments	0.0208470082702882
GO:0019222	regulation of metabolic process	0.0208470082702882
GO:0031347	regulation of defense response	0.0208470082702882
GO:0051241	negative regulation of multicellular organismal process	0.0208470082702882
GO:0050727	regulation of inflammatory response	0.0208470082702882
GO:0016444	somatic cell DNA recombination	0.0208470082702882
GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus	0.0208470082702882
GO:0016070	RNA metabolic process	0.0208470082702882
GO:0006690	icosanoid metabolic process	0.0208470082702882
GO:0016445	somatic diversification of immunoglobulins	0.0208470082702882
GO:0002200	somatic diversification of immune receptors	0.0218430977084959
GO:0043170	macromolecule metabolic process	0.0222453518230858
GO:0050864	regulation of B cell activation	0.0243899157232587
GO:0002377	immunoglobulin production	0.0252756617130364
GO:0002440	production of molecular mediator of immune response	0.0253148365305417
GO:0048522	positive regulation of cellular process	0.0253148365305417
GO:0048583	regulation of response to stimulus	0.0271470582401027
GO:0019221	cytokine and chemokine mediated signaling pathway	0.0273279768087273
GO:0010467	gene expression	0.0295513593912224
GO:0003700	transcription factor activity	0.0295513593912224
GO:0048518	positive regulation of biological process	0.0309642625493989
GO:0044238	primary metabolic process	0.0336469501789967
GO:0044237	cellular metabolic process	0.0336585119279058
GO:0051251	positive regulation of lymphocyte activation	0.0338248111422986
GO:0019887	protein kinase regulator activity	0.0344361317682002
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0356074807768266
GO:0019955	cytokine binding	0.0356074807768266
GO:0016064	immunoglobulin mediated immune response	0.0366900650795972
GO:0019724	B cell mediated immunity	0.0367149999362538
GO:0006310	DNA recombination	0.0372632124910298
GO:0019207	kinase regulator activity	0.0372632124910298
GO:0050794	regulation of cellular process	0.0404470684666517
GO:0051249	regulation of lymphocyte activation	0.0407069757311571
GO:0042113	B cell activation	0.0411267233716689
GO:0050865	regulation of cell activation	0.0411267233716689
GO:0002250	adaptive immune response	0.0415255534530609
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0415255534530609
GO:0002449	lymphocyte mediated immunity	0.0424038110968864
GO:0002443	leukocyte mediated immunity	0.0450674053215862
GO:0050789	regulation of biological process	0.0493197986807879
GO:0050776	regulation of immune response	0.0493197986807879
GO:0002682	regulation of immune system process	0.0496297266270087

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
gastrointestinal system	1.37e-08	47
intestine	2.12e-08	31
endoderm-derived structure	2.97e-08	118
endoderm	2.97e-08	118
presumptive endoderm	2.97e-08	118
digestive system	7.50e-08	116
digestive tract	7.50e-08	116
primitive gut	7.50e-08	116
subdivision of digestive tract	3.21e-07	114
mucosa	4.89e-07	15

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}