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Coexpression cluster:C4742: Difference between revisions

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|tf_chipseq_enrich=STAT3#6774;3:10.5194649971542:0.000858918453041531:0.00646007376618209!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0110180231362326
|tf_chipseq_enrich=STAT3#6774;3:10.5194649971542:0.000858918453041531:0.00646007376618209!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0110180231362326
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}}
}}

Revision as of 16:56, 26 November 2012


Full id: C4742_skeletal_Mesothelial_heart_mature_mesenchymal_caudate_left



Phase1 CAGE Peaks

Hg19::chr8:22250334..22250354,+p7@SLC39A14
Hg19::chr8:22250363..22250385,+p5@SLC39A14
Hg19::chr8:22250390..22250405,+p6@SLC39A14


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism1.52e-22114
tube8.20e-16192
anatomical conduit8.56e-15240
splanchnic layer of lateral plate mesoderm1.54e-1483
primary circulatory organ1.01e-1327
epithelium1.51e-11306
structure with developmental contribution from neural crest2.26e-11132
systemic artery2.78e-1133
systemic arterial system2.78e-1133
cell layer3.56e-11309
artery3.78e-1142
arterial blood vessel3.78e-1142
arterial system3.78e-1142
vessel6.69e-1168
heart6.93e-1124
primitive heart tube6.93e-1124
primary heart field6.93e-1124
anterior lateral plate mesoderm6.93e-1124
heart tube6.93e-1124
heart primordium6.93e-1124
cardiac mesoderm6.93e-1124
cardiogenic plate6.93e-1124
heart rudiment6.93e-1124
neural tube9.35e-1156
neural rod9.35e-1156
future spinal cord9.35e-1156
neural keel9.35e-1156
anatomical cluster1.31e-10373
circulatory system1.55e-10112
multi-tissue structure7.12e-10342
epithelial tube open at both ends7.28e-1059
blood vessel7.28e-1059
blood vasculature7.28e-1059
vascular cord7.28e-1059
muscle tissue9.13e-1064
musculature9.13e-1064
musculature of body9.13e-1064
regional part of nervous system1.04e-0953
regional part of brain1.04e-0953
neural nucleus3.25e-099
nucleus of brain3.25e-099
cardiovascular system6.18e-09109
skeletal muscle tissue7.03e-0962
striated muscle tissue7.03e-0962
myotome7.03e-0962
epithelial tube7.72e-09117
compound organ1.14e-0868
female gonad3.02e-0813
vasculature3.25e-0878
vascular system3.25e-0878
neural plate3.28e-0882
presumptive neural plate3.28e-0882
multilaminar epithelium6.05e-0883
brain grey matter1.43e-0734
gray matter1.43e-0734
neurectoderm2.20e-0786
ecto-epithelium2.23e-07104
regional part of forebrain2.31e-0741
forebrain2.31e-0741
anterior neural tube2.31e-0741
future forebrain2.31e-0741
smooth muscle tissue3.06e-0715
somite3.11e-0771
presomitic mesoderm3.11e-0771
presumptive segmental plate3.11e-0771
dermomyotome3.11e-0771
trunk paraxial mesoderm3.11e-0771
brainstem3.95e-076
blood vessel smooth muscle4.45e-0710
arterial system smooth muscle4.45e-0710
artery smooth muscle tissue4.45e-0710
aorta smooth muscle tissue4.45e-0710
telencephalon4.86e-0734
paraxial mesoderm5.12e-0772
presumptive paraxial mesoderm5.12e-0772
telencephalic nucleus5.76e-077
brain7.76e-0768
future brain7.76e-0768
dense mesenchyme tissue8.27e-0773
right ovary8.61e-075
Disease
Ontology termp-valuen
ovarian cancer4.29e-1314


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
STAT3#6774310.51946499715420.0008589184530415310.00646007376618209
ZNF263#1012738.221841637010680.001799043925565870.0110180231362326



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.