Coexpression cluster:C4702

Full id: C4702_bone_corpus_Endothelial_optic_diencephalon_thalamus_Wilms

Phase1 CAGE Peaks

Hg19::chr7:86688940..86688951,-	p4@KIAA1324L
Hg19::chr7:86688955..86688988,-	p1@KIAA1324L
Hg19::chr7:86688990..86689026,-	p2@KIAA1324L

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	3.45e-10	24
endothelial cell	1.85e-07	36
blood vessel endothelial cell	5.07e-07	18
embryonic blood vessel endothelial progenitor cell	5.07e-07	18

Uber Anatomy

Ontology term	p-value	n
adult organism	3.17e-31	114
neural tube	5.50e-27	56
neural rod	5.50e-27	56
future spinal cord	5.50e-27	56
neural keel	5.50e-27	56
regional part of nervous system	3.04e-25	53
regional part of brain	3.04e-25	53
central nervous system	6.22e-23	81
nervous system	3.05e-22	89
regional part of forebrain	2.90e-21	41
forebrain	2.90e-21	41
anterior neural tube	2.90e-21	41
future forebrain	2.90e-21	41
brain	5.60e-21	68
future brain	5.60e-21	68
neural plate	1.24e-19	82
presumptive neural plate	1.24e-19	82
neurectoderm	5.27e-19	86
telencephalon	4.43e-18	34
brain grey matter	6.16e-18	34
gray matter	6.16e-18	34
cerebral hemisphere	6.56e-17	32
regional part of telencephalon	7.20e-17	32
pre-chordal neural plate	1.03e-13	61
regional part of cerebral cortex	1.89e-13	22
ecto-epithelium	6.79e-13	104
cerebral cortex	8.65e-13	25
pallium	8.65e-13	25
neocortex	1.99e-12	20
structure with developmental contribution from neural crest	7.71e-12	132
tube	5.22e-10	192
anatomical conduit	8.23e-10	240
ectoderm-derived structure	1.88e-07	171
ectoderm	1.88e-07	171
presumptive ectoderm	1.88e-07	171
blood vessel endothelium	5.07e-07	18
endothelium	5.07e-07	18
cardiovascular system endothelium	5.07e-07	18
anatomical cluster	5.08e-07	373
posterior neural tube	5.79e-07	15
chordal neural plate	5.79e-07	15

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0191145692128905
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0281333986328825
CTCFL#140690	3	19.7464743589744	0.000129837200555116	0.00172344527056124
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0327753736389724
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.032430640388031
EBF1#1879	3	8.906466846569	0.0014152328356098	0.00919302787151713
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0322478753863326
FOXA1#3169	3	11.0814197493855	0.00073475527569867	0.00584263029074869
HMGN3#9324	3	8.17854772335059	0.00182776694216421	0.0109211140038153
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.0128738860974726
RAD21#5885	3	10.3550338954563	0.000900491207356542	0.00668655536474297
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0278282129462136
SMC3#9126	3	15.0449328449328	0.000293582542037187	0.00310810614372243
TAF7#6879	3	11.4330694049239	0.000669018198194583	0.00545743900658002
TCF12#6938	3	10.6344649021864	0.000831352399020207	0.006320105779682
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0140916534823325

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.