Coexpression cluster:C110

Full id: C110_leukemia_chronic_Eosinophils_acute_Whole_CD34_Lymphatic

Phase1 CAGE Peaks

Hg19::chr10:82510229..82510235,+	p@chr10:82510229..82510235 +
Hg19::chr11:109773840..109773869,-	p@chr11:109773840..109773869 -
Hg19::chr11:59738815..59738853,+	p@chr11:59738815..59738853 +
Hg19::chr11:59886734..59886742,-	p@chr11:59886734..59886742 -
Hg19::chr11:59886775..59886783,-	p@chr11:59886775..59886783 -
Hg19::chr11:91527340..91527347,-	p@chr11:91527340..91527347 -
Hg19::chr11:91556061..91556064,-	p@chr11:91556061..91556064 -
Hg19::chr11:92767986..92767992,+	p@chr11:92767986..92767992 +
Hg19::chr12:43537916..43537937,+	p@chr12:43537916..43537937 +
Hg19::chr12:62714046..62714064,+	p@chr12:62714046..62714064 +
Hg19::chr12:62714083..62714089,+	p@chr12:62714083..62714089 +
Hg19::chr12:73854074..73854088,+	p@chr12:73854074..73854088 +
Hg19::chr12:89421452..89421478,-	p@chr12:89421452..89421478 -
Hg19::chr12:89421491..89421499,-	p@chr12:89421491..89421499 -
Hg19::chr12:89421523..89421536,-	p@chr12:89421523..89421536 -
Hg19::chr12:89421559..89421571,-	p@chr12:89421559..89421571 -
Hg19::chr12:93966332..93966344,+	p26@SOCS2
Hg19::chr12:94312960..94312962,-	p@chr12:94312960..94312962 -
Hg19::chr12:94337705..94337712,-	p1@ENST00000550687
Hg19::chr13:107448278..107448283,+	p@chr13:107448278..107448283 +
Hg19::chr13:109310382..109310414,+	p@chr13:109310382..109310414 +
Hg19::chr13:84070851..84070863,+	p@chr13:84070851..84070863 +
Hg19::chr13:92872139..92872145,+	p@chr13:92872139..92872145 +
Hg19::chr14:100841739..100841750,-	p12@WARS
Hg19::chr14:64746875..64746885,-	p@chr14:64746875..64746885 -
Hg19::chr14:89935615..89935620,-	p@chr14:89935615..89935620 -
Hg19::chr15:55529680..55529688,-	p@chr15:55529680..55529688 -
Hg19::chr15:55529725..55529732,-	p@chr15:55529725..55529732 -
Hg19::chr15:55529837..55529855,-	p@chr15:55529837..55529855 -
Hg19::chr15:81061877..81061880,-	p@chr15:81061877..81061880 -
Hg19::chr16:10450937..10450942,-	p@chr16:10450937..10450942 -
Hg19::chr16:11155837..11155846,-	p@chr16:11155837..11155846 -
Hg19::chr17:6745896..6745904,-	p@chr17:6745896..6745904 -
Hg19::chr18:62480393..62480396,+	p@chr18:62480393..62480396 +
Hg19::chr18:8914110..8914145,+	p@chr18:8914110..8914145 +
Hg19::chr19:21770017..21770070,-	p1@ENST00000509103 p1@uc002nqe.2
Hg19::chr19:21861007..21861014,-	p@chr19:21861007..21861014 -
Hg19::chr19:21861057..21861085,-	p@chr19:21861057..21861085 -
Hg19::chr19:21861119..21861122,-	p@chr19:21861119..21861122 -
Hg19::chr19:41860089..41860098,+	p@chr19:41860089..41860098 +
Hg19::chr19:52005184..52005223,-	p4@SIGLEC12
Hg19::chr19:52102540..52102544,+	p1@BC034798
Hg19::chr1:101548494..101548504,+	p2@ENST00000451213
Hg19::chr1:101550279..101550290,-	p@chr1:101550279..101550290 -
Hg19::chr1:101550310..101550314,-	p@chr1:101550310..101550314 -
Hg19::chr1:149215297..149215302,-	p1@ENST00000517017
Hg19::chr1:185409237..185409244,-	p@chr1:185409237..185409244 -
Hg19::chr1:186166946..186166955,-	p@chr1:186166946..186166955 -
Hg19::chr1:186166968..186166976,-	p@chr1:186166968..186166976 -
Hg19::chr1:246357016..246357020,-	p19@SMYD3
Hg19::chr1:246357031..246357043,-	p8@SMYD3
Hg19::chr1:246357046..246357053,-	p13@SMYD3
Hg19::chr1:246357055..246357065,-	p10@SMYD3
Hg19::chr1:248126421..248126422,-	p@chr1:248126421..248126422 -
Hg19::chr1:90461589..90461597,+	p@chr1:90461589..90461597 +
Hg19::chr20:11560028..11560041,-	p@chr20:11560028..11560041 -
Hg19::chr20:23168661..23168671,+	p2@uc002wsw.1
Hg19::chr20:23168759..23168765,+	p1@ENST00000411595
Hg19::chr20:29463016..29463024,+	p@chr20:29463016..29463024 +
Hg19::chr20:45104113..45104118,-	p@chr20:45104113..45104118 -
Hg19::chr21:16125761..16125771,-	p4@ENST00000454128
Hg19::chr21:16125773..16125787,-	p1@ENST00000454128
Hg19::chr21:16135200..16135219,-	p@chr21:16135200..16135219 -
Hg19::chr21:16135254..16135263,-	p@chr21:16135254..16135263 -
Hg19::chr21:20979193..20979206,-	p@chr21:20979193..20979206 -
Hg19::chr21:20979342..20979352,-	p@chr21:20979342..20979352 -
Hg19::chr21:20979359..20979385,-	p@chr21:20979359..20979385 -
Hg19::chr21:21202916..21202926,-	p@chr21:21202916..21202926 -
Hg19::chr21:21202982..21202985,-	p@chr21:21202982..21202985 -
Hg19::chr21:21367600..21367604,-	p@chr21:21367600..21367604 -
Hg19::chr21:21372122..21372161,-	p@chr21:21372122..21372161 -
Hg19::chr21:21372239..21372250,-	p@chr21:21372239..21372250 -
Hg19::chr21:21377104..21377109,+	p@chr21:21377104..21377109 +
Hg19::chr21:32266017..32266021,+	p@chr21:32266017..32266021 +
Hg19::chr21:43981989..43982000,+	p@chr21:43981989..43982000 +
Hg19::chr22:30270380..30270382,+	p@chr22:30270380..30270382 +
Hg19::chr22:32869636..32869640,-	p@chr22:32869636..32869640 -
Hg19::chr2:123793061..123793088,-	p@chr2:123793061..123793088 -
Hg19::chr2:124452755..124452774,+	p1@ENST00000431242
Hg19::chr2:159992352..159992360,+	p24@TANC1
Hg19::chr2:187304524..187304526,-	p@chr2:187304524..187304526 -
Hg19::chr2:187420285..187420288,+	p@chr2:187420285..187420288 +
Hg19::chr2:194048135..194048139,-	p@chr2:194048135..194048139 -
Hg19::chr2:196044487..196044490,-	p@chr2:196044487..196044490 -
Hg19::chr2:217750762..217750766,+	p@chr2:217750762..217750766 +
Hg19::chr3:107869320..107869324,-	p@chr3:107869320..107869324 -
Hg19::chr3:134760394..134760397,-	p@chr3:134760394..134760397 -
Hg19::chr3:151634004..151634008,-	p@chr3:151634004..151634008 -
Hg19::chr3:155316733..155316741,+	p@chr3:155316733..155316741 +
Hg19::chr3:165550629..165550631,-	p@chr3:165550629..165550631 -
Hg19::chr3:178236636..178236643,-	p@chr3:178236636..178236643 -
Hg19::chr3:183079303..183079309,+	p@chr3:183079303..183079309 +
Hg19::chr3:194899235..194899237,+	p@chr3:194899235..194899237 +
Hg19::chr3:52713780..52713784,-	p18@PBRM1
Hg19::chr3:77146849..77146869,+	p44@ROBO2
Hg19::chr4:156831099..156831108,+	p@chr4:156831099..156831108 +
Hg19::chr4:156831130..156831160,+	p@chr4:156831130..156831160 +
Hg19::chr4:156831165..156831168,+	p@chr4:156831165..156831168 +
Hg19::chr4:159520469..159520513,+	p@chr4:159520469..159520513 +
Hg19::chr4:159959868..159959874,-	p6@C4orf45
Hg19::chr4:159959878..159959889,-	p3@C4orf45
Hg19::chr4:175516623..175516646,+	p@chr4:175516623..175516646 +
Hg19::chr4:175516672..175516677,+	p@chr4:175516672..175516677 +
Hg19::chr4:175516690..175516703,+	p@chr4:175516690..175516703 +
Hg19::chr4:175516905..175516912,+	p@chr4:175516905..175516912 +
Hg19::chr4:175604048..175604063,-	p@chr4:175604048..175604063 -
Hg19::chr4:190802776..190802787,+	p1@ENST00000503609
Hg19::chr4:63136352..63136359,+	p@chr4:63136352..63136359 +
Hg19::chr4:74958668..74958673,+	p@chr4:74958668..74958673 +
Hg19::chr4:74961575..74961579,-	p@chr4:74961575..74961579 -
Hg19::chr4:75197145..75197152,-	p@chr4:75197145..75197152 -
Hg19::chr4:80116986..80116991,+	p1@ENST00000507476 p1@ENST00000507761 p1@ENST00000515597 p1@uc003hls.2
Hg19::chr5:151323023..151323025,+	p@chr5:151323023..151323025 +
Hg19::chr5:151326534..151326539,+	p@chr5:151326534..151326539 +
Hg19::chr5:151487984..151487988,+	p@chr5:151487984..151487988 +
Hg19::chr5:151573968..151573973,+	p@chr5:151573968..151573973 +
Hg19::chr5:20313972..20313975,-	p@chr5:20313972..20313975 -
Hg19::chr5:25479260..25479266,-	p@chr5:25479260..25479266 -
Hg19::chr5:27140770..27140776,-	p@chr5:27140770..27140776 -
Hg19::chr5:45038620..45038622,+	p@chr5:45038620..45038622 +
Hg19::chr5:45694799..45694803,+	p@chr5:45694799..45694803 +
Hg19::chr5:55412774..55412784,-	p5@ANKRD55
Hg19::chr5:55412798..55412826,-	p3@ANKRD55
Hg19::chr5:80813428..80813456,-	p@chr5:80813428..80813456 -
Hg19::chr5:81056711..81056729,-	p@chr5:81056711..81056729 -
Hg19::chr6:123689274..123689283,-	p@chr6:123689274..123689283 -
Hg19::chr6:123689316..123689324,-	p@chr6:123689316..123689324 -
Hg19::chr6:135514234..135514237,-	p@chr6:135514234..135514237 -
Hg19::chr6:145156934..145156943,+	p@chr6:145156934..145156943 +
Hg19::chr6:145156948..145156958,+	p@chr6:145156948..145156958 +
Hg19::chr6:145156968..145156977,+	p@chr6:145156968..145156977 +
Hg19::chr6:145156993..145157003,+	p@chr6:145156993..145157003 +
Hg19::chr6:162565540..162565545,+	p@chr6:162565540..162565545 +
Hg19::chr6:23903074..23903085,-	p@chr6:23903074..23903085 -
Hg19::chr6:24974731..24974733,-	p@chr6:24974731..24974733 -
Hg19::chr6:2919588..2919590,+	p@chr6:2919588..2919590 +
Hg19::chr6:37465165..37465170,+	p@chr6:37465165..37465170 +
Hg19::chr6:45414987..45415001,+	p@chr6:45414987..45415001 +
Hg19::chr6:54550836..54550845,+	p@chr6:54550836..54550845 +
Hg19::chr6:66356511..66356517,-	p@chr6:66356511..66356517 -
Hg19::chr7:119584177..119584190,-	p@chr7:119584177..119584190 -
Hg19::chr7:143123926..143123957,+	p@chr7:143123926..143123957 +
Hg19::chr7:147076040..147076044,+	p@chr7:147076040..147076044 +
Hg19::chr7:147076084..147076089,+	p@chr7:147076084..147076089 +
Hg19::chr7:147076150..147076155,+	p@chr7:147076150..147076155 +
Hg19::chr7:1893440..1893449,+	p@chr7:1893440..1893449 +
Hg19::chr8:114083325..114083335,+	p@chr8:114083325..114083335 +
Hg19::chr8:114083343..114083350,+	p@chr8:114083343..114083350 +
Hg19::chr8:114083596..114083630,+	p@chr8:114083596..114083630 +
Hg19::chr8:114168274..114168293,+	p@chr8:114168274..114168293 +
Hg19::chr8:120464833..120464838,+	p@chr8:120464833..120464838 +
Hg19::chr8:125661200..125661204,-	p@chr8:125661200..125661204 -
Hg19::chr8:130558453..130558462,+	p@chr8:130558453..130558462 +
Hg19::chr8:130560726..130560739,-	p@chr8:130560726..130560739 -
Hg19::chr8:130560752..130560768,-	p@chr8:130560752..130560768 -
Hg19::chr8:130560771..130560781,-	p@chr8:130560771..130560781 -
Hg19::chr8:130596435..130596439,-	p@chr8:130596435..130596439 -
Hg19::chr8:13068794..13068799,+	p@chr8:13068794..13068799 +
Hg19::chr8:130735268..130735270,-	p@chr8:130735268..130735270 -
Hg19::chr8:13966008..13966024,-	p@chr8:13966008..13966024 -
Hg19::chr8:141312910..141312916,-	p24@TRAPPC9
Hg19::chr8:17924774..17924781,+	p@chr8:17924774..17924781 +
Hg19::chr8:88984168..88984173,+	p@chr8:88984168..88984173 +
Hg19::chr8:91267129..91267158,+	p@chr8:91267129..91267158 +
Hg19::chr8:91270731..91270743,+	p@chr8:91270731..91270743 +
Hg19::chr8:91275313..91275315,+	p@chr8:91275313..91275315 +
Hg19::chr9:105828267..105828270,-	p@chr9:105828267..105828270 -
Hg19::chr9:135774778..135774781,-	p@chr9:135774778..135774781 -
Hg19::chr9:29966003..29966007,-	p@chr9:29966003..29966007 -
Hg19::chrX:11153467..11153471,+	p@chrX:11153467..11153471 +
Hg19::chrX:135863609..135863618,-	p30@ARHGEF6
Hg19::chrX:135866644..135866662,+	p@chrX:135866644..135866662 +
Hg19::chrX:47536072..47536081,+	p@chrX:47536072..47536081 +
Hg19::chrY:23583803..23583808,-	p@chrY:23583803..23583808 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005148	prolactin receptor binding	0.0388475220567192
GO:0008269	JAK pathway signal transduction adaptor activity	0.0388475220567192
GO:0008046	axon guidance receptor activity	0.0388475220567192
GO:0008268	receptor signaling protein tyrosine kinase signaling protein activity	0.0388475220567192
GO:0005131	growth hormone receptor binding	0.0413994100749266
GO:0016568	chromatin modification	0.0413994100749266
GO:0004830	tryptophan-tRNA ligase activity	0.0453034349388286
GO:0006436	tryptophanyl-tRNA aminoacylation	0.0453034349388286

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
hematopoietic stem cell	3.54e-32	172
angioblastic mesenchymal cell	3.54e-32	172
hematopoietic cell	3.00e-31	182
hematopoietic oligopotent progenitor cell	7.30e-31	165
hematopoietic multipotent progenitor cell	7.30e-31	165
myeloid cell	1.28e-28	112
common myeloid progenitor	1.28e-28	112
leukocyte	1.41e-17	140
hematopoietic lineage restricted progenitor cell	5.54e-16	124
myeloid leukocyte	3.05e-14	76
nongranular leukocyte	1.68e-12	119
granulocyte monocyte progenitor cell	3.85e-12	71
myeloid lineage restricted progenitor cell	4.20e-12	70
classical monocyte	1.44e-11	45
CD14-positive, CD16-negative classical monocyte	9.89e-11	42
macrophage dendritic cell progenitor	6.13e-10	65
monopoietic cell	2.94e-09	63
monocyte	2.94e-09	63
monoblast	2.94e-09	63
promonocyte	2.94e-09	63

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	2.24e-18	112
hematopoietic system	1.09e-17	102
blood island	1.09e-17	102
immune system	2.86e-12	115
bone marrow	5.22e-11	80
bone element	2.40e-10	86
blood	9.95e-07	15
haemolymphatic fluid	9.95e-07	15
organism substance	9.95e-07	15

Disease

Ontology term	p-value	n
hematologic cancer	8.45e-21	51
immune system cancer	8.45e-21	51
leukemia	1.64e-18	39
myeloid leukemia	7.54e-17	31
cancer	3.33e-11	235
disease of cellular proliferation	9.07e-11	239
organ system cancer	2.33e-10	137

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
GATA1#2623	29	2.26005135730007	3.1367205728994e-05	0.000632668906745926
GATA2#2624	31	2.27064875712744	1.46045492790064e-05	0.00034712893084892
TAL1#6886	24	4.1198091968883	5.28616122714797e-09	4.23375300921861e-07

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---