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|ontology_enrichment_disease=DOID:1749!3.46e-07!14
|ontology_enrichment_disease=DOID:1749!3.46e-07!14
|ontology_enrichment_uberon=UBERON:0000468!9.05e-20!659;UBERON:0000475!2.35e-19!365;UBERON:0000481!3.28e-19!347;UBERON:0004119!1.12e-18!169;UBERON:0000925!1.12e-18!169;UBERON:0006595!1.12e-18!169;UBERON:0004111!3.90e-18!241;UBERON:0000477!1.88e-15!286;UBERON:0000467!2.79e-15!625;UBERON:0000922!3.41e-15!612;UBERON:0000480!6.09e-15!626;UBERON:0001007!8.54e-15!155;UBERON:0001555!8.54e-15!155;UBERON:0007026!8.54e-15!155;UBERON:0000483!2.19e-14!309;UBERON:0000119!6.38e-14!312;UBERON:0002050!3.73e-13!605;UBERON:0005423!3.73e-13!605;UBERON:0000923!7.04e-13!604;UBERON:0005291!7.04e-13!604;UBERON:0006598!7.04e-13!604;UBERON:0002532!7.04e-13!604;UBERON:0000064!1.98e-12!219;UBERON:0000466!1.04e-11!126;UBERON:0004921!2.65e-11!129;UBERON:0004185!2.65e-11!129;UBERON:0000062!5.07e-11!511;UBERON:0000077!6.86e-11!130;UBERON:0003104!7.03e-11!238;UBERON:0009142!7.03e-11!238;UBERON:0002100!7.60e-11!216;UBERON:0000025!2.68e-10!194;UBERON:0009569!3.08e-10!113;UBERON:0005177!3.11e-09!107;UBERON:0000464!4.35e-09!104;UBERON:0005911!6.08e-09!82;UBERON:0001004!6.17e-09!72;UBERON:0000161!2.62e-08!35;UBERON:0000166!6.28e-08!21;UBERON:0000033!6.32e-08!123;UBERON:0000153!1.11e-07!129;UBERON:0007811!1.11e-07!129;UBERON:0004121!1.21e-07!169;UBERON:0000915!1.86e-07!52;UBERON:0000924!1.87e-07!173;UBERON:0006601!1.87e-07!173;UBERON:0005256!2.00e-07!143;UBERON:0000165!2.73e-07!28;UBERON:0000930!2.73e-07!28;UBERON:0002365!3.43e-07!31;UBERON:0002330!3.43e-07!31;UBERON:0001041!4.31e-07!98;UBERON:0005178!4.65e-07!34;UBERON:0002224!4.65e-07!34;UBERON:0005631!4.70e-07!14;UBERON:0000158!4.70e-07!14;UBERON:0001444!5.35e-07!48
|ontology_enrichment_uberon=UBERON:0000468!9.05e-20!659;UBERON:0000475!2.35e-19!365;UBERON:0000481!3.28e-19!347;UBERON:0004119!1.12e-18!169;UBERON:0000925!1.12e-18!169;UBERON:0006595!1.12e-18!169;UBERON:0004111!3.90e-18!241;UBERON:0000477!1.88e-15!286;UBERON:0000467!2.79e-15!625;UBERON:0000922!3.41e-15!612;UBERON:0000480!6.09e-15!626;UBERON:0001007!8.54e-15!155;UBERON:0001555!8.54e-15!155;UBERON:0007026!8.54e-15!155;UBERON:0000483!2.19e-14!309;UBERON:0000119!6.38e-14!312;UBERON:0002050!3.73e-13!605;UBERON:0005423!3.73e-13!605;UBERON:0000923!7.04e-13!604;UBERON:0005291!7.04e-13!604;UBERON:0006598!7.04e-13!604;UBERON:0002532!7.04e-13!604;UBERON:0000064!1.98e-12!219;UBERON:0000466!1.04e-11!126;UBERON:0004921!2.65e-11!129;UBERON:0004185!2.65e-11!129;UBERON:0000062!5.07e-11!511;UBERON:0000077!6.86e-11!130;UBERON:0003104!7.03e-11!238;UBERON:0009142!7.03e-11!238;UBERON:0002100!7.60e-11!216;UBERON:0000025!2.68e-10!194;UBERON:0009569!3.08e-10!113;UBERON:0005177!3.11e-09!107;UBERON:0000464!4.35e-09!104;UBERON:0005911!6.08e-09!82;UBERON:0001004!6.17e-09!72;UBERON:0000161!2.62e-08!35;UBERON:0000166!6.28e-08!21;UBERON:0000033!6.32e-08!123;UBERON:0000153!1.11e-07!129;UBERON:0007811!1.11e-07!129;UBERON:0004121!1.21e-07!169;UBERON:0000915!1.86e-07!52;UBERON:0000924!1.87e-07!173;UBERON:0006601!1.87e-07!173;UBERON:0005256!2.00e-07!143;UBERON:0000165!2.73e-07!28;UBERON:0000930!2.73e-07!28;UBERON:0002365!3.43e-07!31;UBERON:0002330!3.43e-07!31;UBERON:0001041!4.31e-07!98;UBERON:0005178!4.65e-07!34;UBERON:0002224!4.65e-07!34;UBERON:0005631!4.70e-07!14;UBERON:0000158!4.70e-07!14;UBERON:0001444!5.35e-07!48
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55909e-05,0.105411,0.0997542,0.209692,0.248936,0.0725263,0.102587,0.0742013,0.0552936,0.0457886,0.0514927,0.324236,0.220368,0.258624,0.064656,0.226143,0.460406,0.0438521,0.435508,0.281453,0.0522771,0.0787278,0.164404,0.159873,0.142462,0.143935,0.332403,0.0379537,0.6545,0.187953,0.051459,0.114868,0.0726892,0.18732,0.32305,0.278397,0.245002,0.170848,0.487259,0.302909,0.363016,0.100188,0.223102,0.107653,0.235857,0.419621,0.191914,0.184022,0.216557,0.0178622,0.116818,0.389792,0.36316,0.0625685,0.124464,0.544477,0.0159364,0.101893,0.142875,0.167635,0.171311,0.458838,0.548036,0.0685131,0.130287,0.0661526,0.0815772,0.0993937,0.122878,0.187329,0.0451012,0.0976639,0.351199,0.267945,0.758305,0.278645,0.365775,0.0128057,0.248017,0.22995,0.652972,0.0760151,0.0629459,0.486024,0.0803251,0.226641,0.379174,0.0939463,0.286748,0.367925,0.0471607,0.163865,0.226359,0.0176801,0.499775,0.265324,0.279778,0.141699,0.0887743,0.142302,0.0653269,0.125712,0.264432,0.0994829,0.0604041,0.144185,0.0925862,0.289561,0.199201,0.049937,0.172796,0.0595495,0.071232,0.149346,0.121978,0.22302,0.137423,0.284016,0.0754883,0.299492,0.100006,0.362866,0.197817,0.251078,0.279874,0.133127,0.410303,0.223717,0.426452,0.196838,0.0826805,0.246601,0.193021,0.608002,0.202165,0.0946865,0.120618,0.079499,0.18762,0.195618,0.127688,0.201169,0.220353,0.24948,0.178639,0.291976,0.320355,0.364334,0.15547,0.110256,0.415419,0.14794,0.147307,0.240761,0.225961,0.124417,0.335582,0.317428,0.182843,0.130771,0.327768,0.135777,0.147842,0.0339286,0.217363,0.119015,0.690952,0.21618,0.243266,0.107021,0.238657,0.20272,0.0896967,0.61565,0.0780061,0.0559668,0.230477,0.000372597,0.295555,0.502112,0.724669,0.0478217,9.5926e-06,0.170854,0.0575231,0.174063,0.163504,0.003653,0.54832,0.502211,0.296013,0.649813,0.537932,0.459994,0.523209,0.0465928,0.25423,0.490559,0.45013,0.0334811,0.472542,0.685908,0.0510811,0.174869,0.818701,0.483077,0.590496,0.603763,0.184287,0.627201,0.00784768,0.934991,0.290703,0.017476,0.366999,0.478691,0.360199,0.0690757,0.657141,0.519564,0.365494,0.212703,0.201391,0.0762097,0.0287777,0.579886,0.421038,0.569409,0.0610883,0.545608,0.310552,0.143396,0.0295909,0.829658,0.784052,0.209437,0.11765,0.0514874,0.598945,0.169076,0.464001,0.0572812,0.579004,0.150592,0.839946,0.0500888,0.261575,0.257956,0.264245,0.379063,0.326516,0.522925,0.436016,0.475063,0.202522,0.183837,0.507324,0.126097,0.3955,0.116739,0.212239,0.294954,0.156999,0.35974,0.025886,0.39549,0.234254,0.357409,0.599068,0.721266,0.50338,0.620526,0.404625,0.0151906,0.424691,0.715362,0.479581,0.62689,0.00679433,0.642173,0.284496,0.512545,0.512178,0.563206,0.829402,0.0299859,0.263302,0.00919591,0.180735,0.775168,0.216102,0.00340007,0.109605,0.397869,0.582542,0.226491,0.417131,0.463987,0.627953,0.503881,0.454761,0.639483,0.483658,0.452129,0.301581,0.261657,0.346776,0.466529,0.0458396,0.438176,0.349112,0.155207,0.385425,0.00631453,0.461541,0.386339,0.382854,0.598787,0.139139,0.611661,0.0576521,0.475047,0.557967,5.56654e-05,0.282281,0.612712,0.2536,0.246827,0.00166308,0.70712,0.387134,0.00990479,0.358813,0.668972,0.574252,0.493455,0.0685505,0.457747,0.0694762,0.476541,0.579645,0.447581,0.42505,0.254628,0.713293,0.479347,0.416962,0.000600154,0.378333,0.152547,0.264038,0.22798,0.102495,0.350933,0.263896,0.0446972,0.24452,0.329284,0.242783,0.0947248,0.336551,0.210656,0.246234,0.211271,0.281295,0.267248,0.118257,0.125087,0.215123,0.321224,0.469461,0.325254,0.266651,0.0460393,0.0292096,0.249415,0.283107,0.285648,0.427316,0.391071,0.279553,0.25563,0.240967,0.160955,0.256687,0.0432189,0.122439,0.16188,0.23235,0.290415,0.0713545,0.112422,0.170886,0.267687,0.315656,0.0450921,0.0887542,0.267811,0.00865954,0.147872,0.189388,0.293546,0.210125,0.292967,0.218414,0.0509944,0.0871471,0.0689852,0.0602698,0.341188,0.259328,0.437467,0.201057,0.15696,0.129351,0.141936,0.0786166,0.276997,0.0227344,0.282389,0.251421,0.162089,0.330223,0.387837,0.233244,0.207281,0.327401,0.195748,0.0429696,0.161712,0.237871,0.239139,0.095257,0.328852,0.332769,0.262022,0.04166,0.00394881,0.184534,0.248707,0.31749,0.15156,0.287598,0.313858,0.223773,0.25788,0.181895,0.035332,0.30702,0.202977,0.170837,0.0604859,0.28543,0.222656,0.00239762,0.127111,0.259989,0.0888526,0.355805,0.279739,0.108118,0.259901,0.139723,0.0708274,0.0710478,0.196248,0.102645,0.0539258,0.0709978,0.401939,0.332746,0.271338,0.242121,0.298673,0.244395,0.106889,0.128632,0.0845989,0.159153,0.0842401,0.13698,0.0874421,0.100355,0.167854,0.142846,0.0583767,0.088258,0.117657,0.0486914,0.175784,0.262778,0.373453,0.362662,0.433518,0.184359,0.334474,0.325785,0.257476,0.0472356,0.081972,0.322827,0.229571,0.359036,0.335984,0.171704,0.208256,0.0387226,0.256405,0.362898,0.302133,0.40806,0.151361,0.279606,0.286696,0.150674,0.251128,0.246177,0.35674,0.35852,0.318525,0.213257,0.287217,0.122782,0.410951,0.289049,0.266974,0.125746,0.112897,0.398354,0.222091,0.205977,0.34423,0.0936726,0.343425,0.132374,0.285122,0.22741,0.203996,0.276721,0.321965,0.264707,0.450113
}}
}}

Revision as of 14:01, 5 September 2012


Full id: C2638_breast_bronchogenic_Amniotic_liver_endometrioid_Hepatocyte_serous



Phase1 CAGE Peaks

Hg19::chr22:19950047..19950056,+p9@COMT
Hg19::chr22:19950060..19950096,+p3@COMT
Hg19::chr22:19950097..19950117,+p5@COMT
Hg19::chr22:19950126..19950137,+p14@COMT


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell9.59e-26254
endodermal cell1.48e-1459
endo-epithelial cell1.72e-1343
embryonic cell1.16e-10248
epithelial cell of alimentary canal1.09e-0721
Uber Anatomy
Ontology termp-valuen
multi-cellular organism9.05e-20659
organism subdivision2.35e-19365
multi-tissue structure3.28e-19347
endoderm-derived structure1.12e-18169
endoderm1.12e-18169
presumptive endoderm1.12e-18169
anatomical conduit3.90e-18241
anatomical cluster1.88e-15286
anatomical system2.79e-15625
embryo3.41e-15612
anatomical group6.09e-15626
digestive system8.54e-15155
digestive tract8.54e-15155
primitive gut8.54e-15155
epithelium2.19e-14309
cell layer6.38e-14312
embryonic structure3.73e-13605
developing anatomical structure3.73e-13605
germ layer7.04e-13604
embryonic tissue7.04e-13604
presumptive structure7.04e-13604
epiblast (generic)7.04e-13604
organ part1.98e-12219
immaterial anatomical entity1.04e-11126
subdivision of digestive tract2.65e-11129
endodermal part of digestive tract2.65e-11129
organ5.07e-11511
mixed endoderm/mesoderm-derived structure6.86e-11130
mesenchyme7.03e-11238
entire embryonic mesenchyme7.03e-11238
trunk7.60e-11216
tube2.68e-10194
subdivision of trunk3.08e-10113
trunk region element3.11e-09107
anatomical space4.35e-09104
endo-epithelium6.08e-0982
respiratory system6.17e-0972
orifice2.62e-0835
oral opening6.28e-0821
head6.32e-08123
anterior region of body1.11e-07129
craniocervical region1.11e-07129
ectoderm-derived structure1.21e-07169
thoracic segment of trunk1.86e-0752
ectoderm1.87e-07173
presumptive ectoderm1.87e-07173
trunk mesenchyme2.00e-07143
mouth2.73e-0728
stomodeum2.73e-0728
exocrine gland3.43e-0731
exocrine system3.43e-0731
foregut4.31e-0798
thoracic cavity element4.65e-0734
thoracic cavity4.65e-0734
extraembryonic membrane4.70e-0714
membranous layer4.70e-0714
subdivision of head5.35e-0748
Disease
Ontology termp-valuen
squamous cell carcinoma3.46e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00818022456919604
EBF1#187948.9064668465690.00015887907472010.00199749267902884
ELF1#199744.258097958807540.003041525565781240.0161049426366166
HDAC2#3066413.41562023662633.0859005065161e-050.000627020161478667
HEY1#2346244.040111043105710.00375304636917980.0186303726294391
HMGN3#932448.178547723350590.0002234570284440470.00248299059407042
IRF1#365947.63716375356390.0002938853996185490.00307823661124878
MYC#460945.22228187160940.001344309395272740.00888484552163583
RAD21#5885410.35503389545638.6948481184721e-050.00129540833472911
SMC3#9126415.04493284493281.95092670935632e-050.000438461016996911
SP1#666745.69838137814090.0009482606065333980.00684797327380318
SP2#6668319.61514787038350.0002171004269245340.00248697504525297
TAF1#687243.343046285745290.008005664898701650.0322645533825539
ZNF263#1012748.221841637010680.0002187871180958320.00249262657650383



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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