Coexpression cluster:C613

Full id: C613_CD4_CD19_CD8_Natural_CD14_immature_Peripheral

Phase1 CAGE Peaks

Hg19::chr10:120514851..120514864,+	p@chr10:120514851..120514864 +
Hg19::chr11:66445589..66445601,+	p@chr11:66445589..66445601 +
Hg19::chr12:16035195..16035237,-	p5@EPS8
Hg19::chr15:63796007..63796022,-	p@chr15:63796007..63796022 -
Hg19::chr17:7386814..7386828,+	p@chr17:7386814..7386828 +
Hg19::chr19:14116676..14116682,+	p@chr19:14116676..14116682 +
Hg19::chr1:176176478..176176481,+	p2@ENST00000456125
Hg19::chr1:179335173..179335190,+	p4@AXDND1
Hg19::chr2:157198321..157198340,+	p@chr2:157198321..157198340 +
Hg19::chr2:157198353..157198377,+	p@chr2:157198353..157198377 +
Hg19::chr2:198318580..198318624,-	p1@AK096309
Hg19::chr3:185655763..185655783,-	p1@TRA2B
Hg19::chr5:40679504..40679537,+	p3@PTGER4
Hg19::chr6:43192303..43192348,+	p@chr6:43192303..43192348 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004957	prostaglandin E receptor activity	0.0246190848913119
GO:0030278	regulation of ossification	0.0246190848913119
GO:0004955	prostaglandin receptor activity	0.0246190848913119
GO:0046850	regulation of bone remodeling	0.0246190848913119
GO:0004954	prostanoid receptor activity	0.0246190848913119
GO:0004953	icosanoid receptor activity	0.0246190848913119
GO:0007173	epidermal growth factor receptor signaling pathway	0.0257868660157688
GO:0005070	SH3/SH2 adaptor activity	0.0334876079256093
GO:0060090	molecular adaptor activity	0.0349427208736638
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0349427208736638
GO:0019933	cAMP-mediated signaling	0.0349427208736638
GO:0001503	ossification	0.0349427208736638
GO:0031214	biomineral formation	0.0349427208736638
GO:0030674	protein binding, bridging	0.0349427208736638
GO:0046849	bone remodeling	0.0349427208736638
GO:0048771	tissue remodeling	0.0358204378027972
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0369769702662953
GO:0019935	cyclic-nucleotide-mediated signaling	0.0369769702662953
GO:0007166	cell surface receptor linked signal transduction	0.0477975200649953

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	4.67e-47	172
angioblastic mesenchymal cell	4.67e-47	172
leukocyte	5.55e-44	140
hematopoietic cell	1.56e-43	182
hematopoietic oligopotent progenitor cell	4.71e-43	165
hematopoietic multipotent progenitor cell	4.71e-43	165
nongranular leukocyte	3.44e-35	119
hematopoietic lineage restricted progenitor cell	4.78e-35	124
classical monocyte	2.27e-25	45
CD14-positive, CD16-negative classical monocyte	6.10e-25	42
myeloid cell	5.53e-23	112
common myeloid progenitor	5.53e-23	112
myeloid leukocyte	1.27e-19	76
lymphocyte	9.14e-19	53
common lymphoid progenitor	9.14e-19	53
lymphoid lineage restricted progenitor cell	1.82e-18	52
granulocyte monocyte progenitor cell	2.07e-17	71
macrophage dendritic cell progenitor	9.48e-16	65
myeloid lineage restricted progenitor cell	1.94e-15	70
mesenchymal cell	4.99e-15	358
monopoietic cell	9.51e-15	63
monocyte	9.51e-15	63
monoblast	9.51e-15	63
promonocyte	9.51e-15	63
connective tissue cell	1.27e-14	365
motile cell	8.86e-14	390
T cell	4.49e-10	25
pro-T cell	4.49e-10	25
native cell	6.65e-10	722
mature alpha-beta T cell	6.22e-09	18
alpha-beta T cell	6.22e-09	18
immature T cell	6.22e-09	18
mature T cell	6.22e-09	18
immature alpha-beta T cell	6.22e-09	18
stem cell	1.73e-08	444
multi fate stem cell	2.61e-08	430
lymphocyte of B lineage	6.70e-08	24
pro-B cell	6.70e-08	24
somatic stem cell	7.84e-08	436
B cell	1.35e-07	14

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	8.67e-18	102
blood island	8.67e-18	102
bone marrow	1.52e-15	80
connective tissue	1.44e-14	375
bone element	1.67e-14	86
hemolymphoid system	9.52e-14	112
skeletal element	9.63e-10	101
skeletal system	9.63e-10	101
immune system	3.80e-09	115

Disease

Ontology term	p-value	n
cancer	1.87e-11	235
disease of cellular proliferation	1.12e-10	239
organ system cancer	4.43e-07	137

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.