Coexpression cluster:C1161

Full id: C1161_osteosarcoma_Melanocyte_cerebellum_substantia_thalamus_globus_occipital

Phase1 CAGE Peaks

Hg19::chr12:110510751..110510754,-	p@chr12:110510751..110510754 -
Hg19::chr12:110511424..110511445,-	p5@C12orf76
Hg19::chr13:113698946..113698993,+	p1@MCF2L
Hg19::chr13:113698996..113699013,+	p6@MCF2L
Hg19::chr13:113699029..113699040,+	p11@MCF2L
Hg19::chr16:27730331..27730353,+	p@chr16:27730331..27730353 +
Hg19::chr8:112039622..112039629,-	p1@ENST00000523557

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005089	Rho guanyl-nucleotide exchange factor activity	0.0332038149063935
GO:0035023	regulation of Rho protein signal transduction	0.0332038149063935
GO:0005088	Ras guanyl-nucleotide exchange factor activity	0.0332038149063935
GO:0007266	Rho protein signal transduction	0.0332038149063935
GO:0005085	guanyl-nucleotide exchange factor activity	0.0372071117390792
GO:0046578	regulation of Ras protein signal transduction	0.0372071117390792
GO:0007265	Ras protein signal transduction	0.0372071117390792
GO:0005083	small GTPase regulator activity	0.0372071117390792
GO:0051056	regulation of small GTPase mediated signal transduction	0.0372071117390792
GO:0030695	GTPase regulator activity	0.049452490286118

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
skin fibroblast	2.25e-08	23

Uber Anatomy

Ontology term	p-value	n
adult organism	1.06e-50	115
neural tube	1.39e-43	57
neural rod	1.39e-43	57
future spinal cord	1.39e-43	57
neural keel	1.39e-43	57
brain	9.68e-38	69
future brain	9.68e-38	69
central nervous system	2.80e-37	82
regional part of brain	8.61e-37	59
regional part of nervous system	1.46e-34	94
nervous system	1.46e-34	94
anterior neural tube	2.47e-34	42
regional part of forebrain	1.03e-33	41
forebrain	1.03e-33	41
future forebrain	1.03e-33	41
neurectoderm	2.01e-32	90
neural plate	7.85e-31	86
presumptive neural plate	7.85e-31	86
gray matter	4.27e-27	34
brain grey matter	4.27e-27	34
telencephalon	5.37e-27	34
regional part of telencephalon	5.01e-26	33
cerebral hemisphere	8.94e-25	32
head	8.94e-23	123
ectoderm	2.17e-22	173
presumptive ectoderm	2.17e-22	173
anterior region of body	3.68e-22	129
craniocervical region	3.68e-22	129
pre-chordal neural plate	3.78e-22	61
ectoderm-derived structure	5.15e-21	169
regional part of cerebral cortex	9.09e-20	22
cerebral cortex	7.96e-18	25
pallium	7.96e-18	25
neocortex	8.97e-18	20
organism subdivision	1.07e-13	365
nucleus of brain	4.71e-11	9
neural nucleus	4.71e-11	9
basal ganglion	6.76e-11	9
nuclear complex of neuraxis	6.76e-11	9
aggregate regional part of brain	6.76e-11	9
collection of basal ganglia	6.76e-11	9
cerebral subcortex	6.76e-11	9
posterior neural tube	3.05e-10	15
chordal neural plate	3.05e-10	15
brainstem	1.35e-09	8
telencephalic nucleus	6.93e-09	7
segmental subdivision of nervous system	2.75e-08	13
diencephalon	3.72e-08	7
future diencephalon	3.72e-08	7
gyrus	9.00e-08	6
segmental subdivision of hindbrain	1.96e-07	12
hindbrain	1.96e-07	12
presumptive hindbrain	1.96e-07	12
temporal lobe	3.21e-07	7
epithelium	5.70e-07	309
tube	5.81e-07	194

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.