Coexpression cluster:C4215

Full id: C4215_retina_medulla_medulloblastoma_pancreas_Retinal_eye_retinoblastoma

Phase1 CAGE Peaks

Hg19::chr2:242871899..242871908,-	p@chr2:242871899..242871908 -
Hg19::chr2:242871926..242871938,-	p@chr2:242871926..242871938 -
Hg19::chr9:73408368..73408372,-	p@chr9:73408368..73408372 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
retinal pigment epithelial cell	3.59e-15	3
visual pigment cell	1.70e-11	4

Uber Anatomy

Ontology term	p-value	n
retina	2.07e-24	5
photoreceptor array	2.07e-24	5
posterior segment of eyeball	2.07e-24	5
neurectoderm	1.97e-17	90
neural plate	1.41e-16	86
presumptive neural plate	1.41e-16	86
layer of retina	3.59e-15	3
pigmented layer of retina	3.59e-15	3
presumptive retinal pigmented epithelium	3.59e-15	3
regional part of nervous system	1.58e-14	94
nervous system	1.58e-14	94
eye	3.73e-14	20
visual system	2.04e-13	21
adult organism	1.31e-12	115
sense organ	3.90e-12	23
sensory system	1.42e-11	24
entire sense organ system	1.42e-11	24
camera-type eye	1.84e-11	19
simple eye	1.84e-11	19
ocular region	1.84e-11	19
optic cup	1.84e-11	19
eye primordium	1.84e-11	19
optic vesicle	1.84e-11	19
head	2.35e-11	123
pre-chordal neural plate	2.42e-11	61
ectoderm	1.21e-10	173
presumptive ectoderm	1.21e-10	173
anterior region of body	1.28e-10	129
craniocervical region	1.28e-10	129
pigment epithelium of eye	1.47e-10	11
central nervous system	1.97e-10	82
face	2.82e-10	21
ectoderm-derived structure	5.89e-10	169
neural tube	8.80e-09	57
neural rod	8.80e-09	57
future spinal cord	8.80e-09	57
neural keel	8.80e-09	57
brain	3.86e-08	69
future brain	3.86e-08	69
posterior neural tube	8.57e-08	15
chordal neural plate	8.57e-08	15
medulla oblongata	1.30e-07	3
myelencephalon	1.30e-07	3
future myelencephalon	1.30e-07	3
ectodermal placode	3.59e-07	29
male genital duct	4.01e-07	3
internal male genitalia	4.01e-07	3
regional part of brain	5.78e-07	59
caudate-putamen	7.81e-07	3
dorsal striatum	7.81e-07	3

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.