Coexpression cluster:C403

Full id: C403_small_Neutrophils_temporal_leiomyoma_Hair_colon_pancreas

Phase1 CAGE Peaks

Hg19::chr15:90333754..90333771,-	p@chr15:90333754..90333771 -
Hg19::chr15:90334271..90334330,-	p@chr15:90334271..90334330 -
Hg19::chr15:90335468..90335503,-	p@chr15:90335468..90335503 -
Hg19::chr15:90335773..90335792,-	p@chr15:90335773..90335792 -
Hg19::chr15:90336331..90336350,-	p20@ANPEP
Hg19::chr15:90340830..90340881,-	p@chr15:90340830..90340881 -
Hg19::chr15:90344690..90344735,-	p@chr15:90344690..90344735 -
Hg19::chr15:90344759..90344769,-	p@chr15:90344759..90344769 -
Hg19::chr15:90346462..90346504,+	p@chr15:90346462..90346504 +
Hg19::chr15:90346527..90346545,-	p@chr15:90346527..90346545 -
Hg19::chr15:90346711..90346744,-	p@chr15:90346711..90346744 -
Hg19::chr15:90346918..90346991,-	p@chr15:90346918..90346991 -
Hg19::chr15:90347171..90347214,-	p8@ANPEP
Hg19::chr15:90347564..90347578,-	p15@ANPEP
Hg19::chr15:90347748..90347765,-	p19@ANPEP
Hg19::chr15:90347792..90347817,-	p6@ANPEP
Hg19::chr15:90348382..90348416,-	p16@ANPEP
Hg19::chr15:90348639..90348671,-	p12@ANPEP
Hg19::chr15:90348673..90348697,-	p11@ANPEP
Hg19::chr15:90349254..90349268,-	p@chr15:90349254..90349268 -
Hg19::chr15:90349462..90349473,-	p11@AB462940
Hg19::chr15:90349509..90349523,-	p7@AB462940
Hg19::chr15:90349753..90349762,-	p9@AB462940
Hg19::chr15:90349765..90349774,-	p10@AB462940
Hg19::chr15:90349797..90349814,-	p3@AB462940
Hg19::chr15:90349899..90349910,-	p14@ANPEP

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016284	alanine aminopeptidase activity	0.02320538482672
GO:0004179	membrane alanyl aminopeptidase activity	0.02320538482672
GO:0005793	ER-Golgi intermediate compartment	0.02320538482672
GO:0004177	aminopeptidase activity	0.0268750735900153
GO:0008235	metalloexopeptidase activity	0.0268750735900153
GO:0001525	angiogenesis	0.0268750735900153
GO:0048514	blood vessel morphogenesis	0.0268750735900153
GO:0048646	anatomical structure formation	0.0268750735900153
GO:0001568	blood vessel development	0.0268750735900153
GO:0001944	vasculature development	0.0268750735900153
GO:0008238	exopeptidase activity	0.0275226657247145
GO:0042277	peptide binding	0.0280623258369638
GO:0005625	soluble fraction	0.0291416460614624
GO:0009887	organ morphogenesis	0.0406903724635975
GO:0008237	metallopeptidase activity	0.0406903724635975

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
multi fate stem cell	9.53e-32	430
somatic stem cell	2.57e-30	436
stem cell	1.04e-28	444
somatic cell	1.78e-25	591
connective tissue cell	6.44e-20	365
non-terminally differentiated cell	1.29e-19	180
mesenchymal cell	7.17e-18	358
fibroblast	6.73e-16	75
muscle precursor cell	1.29e-15	57
myoblast	1.29e-15	57
multi-potent skeletal muscle stem cell	1.29e-15	57
contractile cell	1.16e-14	59
muscle cell	4.80e-14	54
CD14-positive, CD16-negative classical monocyte	5.05e-14	42
myeloid leukocyte	6.03e-14	76
motile cell	8.10e-13	390
monopoietic cell	1.73e-12	63
monocyte	1.73e-12	63
monoblast	1.73e-12	63
promonocyte	1.73e-12	63
macrophage dendritic cell progenitor	1.04e-11	65
myeloid lineage restricted progenitor cell	1.61e-11	70
classical monocyte	1.61e-11	45
granulocyte monocyte progenitor cell	1.87e-11	71
smooth muscle cell	4.67e-11	42
smooth muscle myoblast	4.67e-11	42
mesodermal cell	1.20e-10	119
electrically responsive cell	1.40e-10	60
electrically active cell	1.40e-10	60
skin fibroblast	1.48e-09	23
vascular associated smooth muscle cell	2.93e-09	32
animal cell	2.44e-08	679
eukaryotic cell	2.44e-08	679
myeloid cell	4.97e-08	112
common myeloid progenitor	4.97e-08	112

Uber Anatomy

Ontology term	p-value	n
musculoskeletal system	1.30e-25	167
mesoderm	1.41e-21	448
mesoderm-derived structure	1.41e-21	448
presumptive mesoderm	1.41e-21	448
lateral plate mesoderm	3.07e-20	216
connective tissue	5.03e-19	375
dermomyotome	9.52e-19	70
somite	1.07e-17	83
paraxial mesoderm	1.07e-17	83
presomitic mesoderm	1.07e-17	83
presumptive segmental plate	1.07e-17	83
trunk paraxial mesoderm	1.07e-17	83
presumptive paraxial mesoderm	1.07e-17	83
trunk mesenchyme	5.05e-16	143
muscle tissue	1.15e-14	63
musculature	1.15e-14	63
musculature of body	1.15e-14	63
skeletal muscle tissue	2.87e-14	61
striated muscle tissue	2.87e-14	61
myotome	2.87e-14	61
multilaminar epithelium	5.60e-14	82
tissue	6.66e-13	787
immune system	1.29e-12	115
bone marrow	4.09e-12	80
cardiovascular system	1.03e-11	110
vasculature	1.10e-11	79
vascular system	1.10e-11	79
epithelial tube	1.61e-11	118
circulatory system	3.21e-11	113
multi-cellular organism	4.56e-11	659
anatomical system	5.30e-11	625
artery	6.10e-11	42
arterial blood vessel	6.10e-11	42
arterial system	6.10e-11	42
anatomical group	6.56e-11	626
vessel	9.70e-11	69
blood vessel	1.16e-10	60
epithelial tube open at both ends	1.16e-10	60
blood vasculature	1.16e-10	60
vascular cord	1.16e-10	60
hemolymphoid system	3.06e-10	112
bone element	3.75e-10	86
unilaminar epithelium	4.01e-10	138
skeletal element	4.33e-10	101
skeletal system	4.33e-10	101
trunk	6.13e-10	216
hematopoietic system	7.05e-10	102
blood island	7.05e-10	102
systemic artery	1.06e-09	33
systemic arterial system	1.06e-09	33
splanchnic layer of lateral plate mesoderm	2.39e-09	84
integument	7.59e-09	45
integumental system	7.59e-09	45
skin of body	3.04e-07	40
germ layer	6.69e-07	604
embryonic tissue	6.69e-07	604
presumptive structure	6.69e-07	604
epiblast (generic)	6.69e-07	604
embryonic structure	7.42e-07	605
developing anatomical structure	7.42e-07	605

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.