CL:0000576: Difference between revisions
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|located_in= | |located_in= | ||
|name=monocyte | |name=monocyte | ||
|namespace= | |namespace=FANTOM | ||
|obo_creation_date= | |obo_creation_date= | ||
|part_of= | |part_of= | ||
Latest revision as of 16:35, 12 September 2014
| Name: | monocyte | |
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| Namespace: | FANTOM | |
| Definition: | "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, http://www.clt.astate.edu/wwilliam/, MESH:A.11.118.637.555.652] | |
| Xrefs: |
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| Comments: | Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000766(myeloid leukocyte),CL:0002087(nongranular leukocyte) |
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| develops_from: | CL:0000559(promonocyte) |
Children
| is a: | CL:0000860 (classical monocyte),CL:0000875 (non-classical monocyte),CL:0001054 (CD14-positive monocyte),CL:0002393 (intermediate monocyte),FF:11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1),FF:11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2),FF:11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3) |
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| derives from: | FF:0000024 (human CD14-positive monocyte sample),FF:0000044 (human monocyte immature derived dendritic cell sample),FF:0000566 (human Monocyte-derived macrophages 0min after LPS treatment sample),FF:0000567 (human Monocyte-derived macrophages 15min after LPS treatment sample),FF:0000568 (human Monocyte-derived macrophages 30min after LPS treatment sample),FF:0000569 (human Monocyte-derived macrophages 45min after LPS treatment sample),FF:0000570 (human Monocyte-derived macrophages 1h after LPS treatment sample),FF:0000571 (human Monocyte-derived macrophages 80min after LPS treatment sample),FF:0000572 (human Monocyte-derived macrophages 100min after LPS treatment sample),FF:0000573 (human Monocyte-derived macrophages 2h after LPS treatment sample),FF:0000574 (human Monocyte-derived macrophages 2.5h after LPS treatment sample),FF:0000575 (human Monocyte-derived macrophages 3h after LPS treatment sample),FF:0000576 (human Monocyte-derived macrophages 3.5h after LPS treatment sample),FF:0000577 (human Monocyte-derived macrophages 4h after LPS treatment sample),FF:0000578 (human Monocyte-derived macrophages 5h after LPS treatment sample),FF:0000579 (human Monocyte-derived macrophages 6h after LPS treatment sample),FF:0000580 (human Monocyte-derived macrophages 7h after LPS treatment sample),FF:0000581 (human Monocyte-derived macrophages 8h after LPS treatment sample),FF:0000582 (human Monocyte-derived macrophages 10h after LPS treatment sample),FF:0000583 (human Monocyte-derived macrophages 12h after LPS treatment sample),FF:0000584 (human Monocyte-derived macrophages 14h after LPS treatment sample),FF:0000585 (human Monocyte-derived macrophages 16h after LPS treatment sample),FF:0000586 (human Monocyte-derived macrophages 18h after LPS treatment sample),FF:0000587 (human Monocyte-derived macrophages 20h after LPS treatment sample),FF:0000588 (human Monocyte-derived macrophages 22h after LPS treatment sample),FF:0000589 (human Monocyte-derived macrophages 24h after LPS treatment sample),FF:0000590 (human Monocyte-derived macrophages 36h after LPS treatment sample),FF:0000591 (human Monocyte-derived macrophages 48h after LPS treatment sample),FF:0102332 (monocytic leukemia cell line sample) |
| develops from: | CL:0000092 (osteoclast),CL:0000235 (macrophage) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
- 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
- 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
- 11224-116B9 (CD14+ Monocytes, donor1)
- 11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1)
- 11305-117B9 (CD14+ Monocytes, donor2)
- 11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2)
- 11381-118B4 (CD14+ Monocytes, donor3)
- 11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
- 11788-124B6 (CD14+CD16- Monocytes, donor1)
... further results Mouse (Mus musculus)
- 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
- 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
- 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
- 11224-116B9 (CD14+ Monocytes, donor1)
- 11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1)
- 11305-117B9 (CD14+ Monocytes, donor2)
- 11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2)
- 11381-118B4 (CD14+ Monocytes, donor3)
- 11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
- 11788-124B6 (CD14+CD16- Monocytes, donor1)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000576 (monocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
