CL:0000092

Name:	osteoclast
Namespace:	FANTOM
Definition:	"A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
Xrefs:	Expandlinks: BTO:0000968 FMA:66781
Synonyms:	"chondroclast" RELATED []
Comments:	Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.

Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

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Parents

is_a:	CL:0000766(myeloid leukocyte),CL:0001035(bone cell)
develops_from:	CL:0000576(monocyte)
part_of:	UBERON:0001474(bone element)

Children

derives from:	FF:0100969 (osteoclastoma cell sample),FF:0200020 (osteoclast, bone marrow-derived sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

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Human (Homo sapiens)

• 10704-109H2 (osteoclastoma cell line:Hs 706.T)
• 10711-109H9 (fibrous histiocytoma cell line:GCT TIB-223)
• 10731-110B2
• 2379-69A1 (osteoclast, bone marrow derived)

Mouse (Mus musculus)

• 10704-109H2 (osteoclastoma cell line:Hs 706.T)
• 10711-109H9 (fibrous histiocytoma cell line:GCT TIB-223)
• 10731-110B2
• 2379-69A1 (osteoclast, bone marrow derived)

Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000092 (osteoclast), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

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P-value	FFCP	Short description

P-value	FFCP	Short description
1.55e-98	FFCP PHASE2:Hg19::chr11:101742272..101742276,-	p@chr11:101742272..101742276, -
1.55e-98	FFCP PHASE1:Hg19::chr11:101742272..101742276,-	p@chr11:101742272..101742276, -
1.55e-98	FFCP PHASE1:Hg19::chr16:77317713..77317723,+	p1@CU687665
1.55e-98	FFCP PHASE2:Hg19::chr16:77317713..77317723,+	p1@CU687665
2.74e-50	FFCP PHASE2:Hg19::chr5:14034644..14034647,-	p@chr5:14034644..14034647, -
2.74e-50	FFCP PHASE1:Hg19::chr18:71197490..71197495,-	p@chr18:71197490..71197495, -
2.74e-50	FFCP PHASE1:Hg19::chr5:14034644..14034647,-	p@chr5:14034644..14034647, -
2.74e-50	FFCP PHASE2:Hg19::chr18:71197490..71197495,-	p@chr18:71197490..71197495, -
2.74e-50	FFCP PHASE2:Hg19::chr16:51670868..51670880,-	p@chr16:51670868..51670880, -
2.74e-50	FFCP PHASE2:Hg19::chr11:81551043..81551054,-	p@chr11:81551043..81551054, -
2.74e-50	FFCP PHASE1:Hg19::chr16:51670868..51670880,-	p@chr16:51670868..51670880, -
2.74e-50	FFCP PHASE1:Hg19::chr11:81551043..81551054,-	p@chr11:81551043..81551054, -
4.52e-50	FFCP PHASE2:Hg19::chr3:45174403..45174415,+	p@chr3:45174403..45174415, +
4.52e-50	FFCP PHASE1:Hg19::chr3:45174403..45174415,+	p@chr3:45174403..45174415, +
4.52e-50	FFCP PHASE2:Hg19::chr5:23952305..23952310,+	p@chr5:23952305..23952310, +
4.52e-50	FFCP PHASE1:Hg19::chr5:23952305..23952310,+	p@chr5:23952305..23952310, +
4.52e-50	FFCP PHASE2:Hg19::chr4:34480309..34480321,-	p@chr4:34480309..34480321, -
4.52e-50	FFCP PHASE1:Hg19::chr4:34480309..34480321,-	p@chr4:34480309..34480321, -
4.52e-50	FFCP PHASE2:Hg19::chr3:106393655..106393659,+	p@chr3:106393655..106393659, +
4.52e-50	FFCP PHASE1:Hg19::chr3:106393655..106393659,+	p@chr3:106393655..106393659, +
3.61e-34	FFCP PHASE2:Hg19::chr7:119353807..119353812,-	p@chr7:119353807..119353812, -
3.61e-34	FFCP PHASE2:Hg19::chr4:177796841..177796851,+	p1@ENST00000508790
3.61e-34	FFCP PHASE1:Hg19::chr4:177796841..177796851,+	p1@ENST00000508790
3.61e-34	FFCP PHASE1:Hg19::chr7:119353807..119353812,-	p@chr7:119353807..119353812, -
5.04e-34	FFCP PHASE2:Hg19::chr4:46093758..46093781,-	p@chr4:46093758..46093781, -
5.04e-34	FFCP PHASE1:Hg19::chr4:46093758..46093781,-	p@chr4:46093758..46093781, -
5.04e-34	FFCP PHASE2:Hg19::chr10:37004821..37004852,-	p@chr10:37004821..37004852, -
5.04e-34	FFCP PHASE1:Hg19::chr10:37004821..37004852,-	p@chr10:37004821..37004852, -
5.04e-34	FFCP PHASE1:Hg19::chr8:15939682..15939688,+	p@chr8:15939682..15939688, +
5.04e-34	FFCP PHASE2:Hg19::chr8:15939682..15939688,+	p@chr8:15939682..15939688, +
5.04e-34	FFCP PHASE2:Hg19::chrX:132231123..132231140,-	p1@USP26
5.04e-34	FFCP PHASE1:Hg19::chrX:132231123..132231140,-	p1@USP26
7.05e-34	FFCP PHASE2:Hg19::chrX:89462083..89462089,+	p@chrX:89462083..89462089, +
7.05e-34	FFCP PHASE1:Hg19::chrX:89462083..89462089,+	p@chrX:89462083..89462089, +
7.05e-34	FFCP PHASE2:Hg19::chr11:84019133..84019135,-	p@chr11:84019133..84019135, -
7.05e-34	FFCP PHASE1:Hg19::chr11:84019133..84019135,-	p@chr11:84019133..84019135, -
7.05e-34	FFCP PHASE2:Hg19::chr6:155427848..155427862,+	p@chr6:155427848..155427862, +
7.05e-34	FFCP PHASE1:Hg19::chr6:155427848..155427862,+	p@chr6:155427848..155427862, +
5.5e-31	FFCP PHASE2:Hg19::chr3:106556598..106556609,-	p@chr3:106556598..106556609, -
5.5e-31	FFCP PHASE1:Hg19::chr3:106556598..106556609,-	p@chr3:106556598..106556609, -
7.1e-28	FFCP PHASE1:Hg19::chr6:68597008..68597030,-	p@chr6:68597008..68597030, -
7.1e-28	FFCP PHASE2:Hg19::chr6:68597008..68597030,-	p@chr6:68597008..68597030, -
4.32e-26	FFCP PHASE2:Hg19::chr5:27723923..27723927,-	p@chr5:27723923..27723927, -
4.32e-26	FFCP PHASE1:Hg19::chr5:27723923..27723927,-	p@chr5:27723923..27723927, -
4.32e-26	FFCP PHASE2:Hg19::chr11:81549961..81549965,-	p@chr11:81549961..81549965, -
4.32e-26	FFCP PHASE1:Hg19::chr11:81549961..81549965,-	p@chr11:81549961..81549965, -
5.56e-26	FFCP PHASE2:Hg19::chrX:124347061..124347063,-	p@chrX:124347061..124347063, -
5.56e-26	FFCP PHASE1:Hg19::chrX:124347061..124347063,-	p@chrX:124347061..124347063, -
5.56e-26	FFCP PHASE2:Hg19::chrX:132352373..132352384,-	p1@TFDP3
5.56e-26	FFCP PHASE1:Hg19::chrX:132352373..132352384,-	p1@TFDP3
5.56e-26	FFCP PHASE2:Hg19::chr5:153673183..153673186,+	p@chr5:153673183..153673186, +
5.56e-26	FFCP PHASE1:Hg19::chr5:153673183..153673186,+	p@chr5:153673183..153673186, +
5.56e-26	FFCP PHASE2:Hg19::chr4:189864018..189864037,+	p@chr4:189864018..189864037, +
5.56e-26	FFCP PHASE1:Hg19::chr4:189864018..189864037,+	p@chr4:189864018..189864037, +
5.56e-26	FFCP PHASE2:Hg19::chr5:167315847..167315852,+	p@chr5:167315847..167315852, +
5.56e-26	FFCP PHASE1:Hg19::chr5:167315847..167315852,+	p@chr5:167315847..167315852, +
5.56e-26	FFCP PHASE2:Hg19::chrX:89176902..89176913,+	p1@TGIF2LX
5.56e-26	FFCP PHASE1:Hg19::chrX:89176902..89176913,+	p1@TGIF2LX
9.18e-26	FFCP PHASE1:Hg19::chr18:14946224..14946236,+	p1@FLJ44255
9.18e-26	FFCP PHASE2:Hg19::chr18:14946224..14946236,+	p1@FLJ44255
9.18e-26	FFCP PHASE1:Hg19::chr7:12997533..12997536,+	p@chr7:12997533..12997536, +
9.18e-26	FFCP PHASE2:Hg19::chr7:12997533..12997536,+	p@chr7:12997533..12997536, +
1.12e-25	FFCP PHASE1:Hg19::chrX:55246809..55246816,+	p3@PAGE5
1.12e-25	FFCP PHASE2:Hg19::chrX:55246809..55246816,+	p3@PAGE5
4.89e-23	FFCP PHASE2:Hg19::chrX:55246818..55246829,+	p2@PAGE5
4.89e-23	FFCP PHASE1:Hg19::chrX:55246818..55246829,+	p2@PAGE5
3.11e-21	FFCP PHASE1:Hg19::chr8:119905427..119905438,-	p@chr8:119905427..119905438, -
3.11e-21	FFCP PHASE2:Hg19::chr8:119905427..119905438,-	p@chr8:119905427..119905438, -
3.11e-21	FFCP PHASE2:Hg19::chr5:27742047..27742052,-	p@chr5:27742047..27742052, -
3.11e-21	FFCP PHASE1:Hg19::chr5:27742047..27742052,-	p@chr5:27742047..27742052, -
3.11e-21	FFCP PHASE2:Hg19::chr12:127737083..127737103,-	p@chr12:127737083..127737103, -
3.11e-21	FFCP PHASE1:Hg19::chr12:127737083..127737103,-	p@chr12:127737083..127737103, -
3.81e-21	FFCP PHASE2:Hg19::chr5:135378750..135378757,+	p@chr5:135378750..135378757, +
3.81e-21	FFCP PHASE1:Hg19::chr5:135378750..135378757,+	p@chr5:135378750..135378757, +
3.81e-21	FFCP PHASE2:Hg19::chr2:145815206..145815208,+	p@chr2:145815206..145815208, +
3.81e-21	FFCP PHASE1:Hg19::chr2:145815206..145815208,+	p@chr2:145815206..145815208, +
3.81e-21	FFCP PHASE2:Hg19::chr13:87732242..87732246,-	p@chr13:87732242..87732246, -
3.81e-21	FFCP PHASE1:Hg19::chr13:87732242..87732246,-	p@chr13:87732242..87732246, -
3.81e-21	FFCP PHASE1:Hg19::chr19:9811101..9811112,-	p3@ZNF812
3.81e-21	FFCP PHASE2:Hg19::chr19:9811101..9811112,-	p3@ZNF812
3.81e-21	FFCP PHASE2:Hg19::chr9:118595109..118595124,+	p@chr9:118595109..118595124, +
3.81e-21	FFCP PHASE1:Hg19::chr9:118595109..118595124,+	p@chr9:118595109..118595124, +
4.66e-21	FFCP PHASE2:Hg19::chrX:140336680..140336697,-	p2@SPANXC
4.66e-21	FFCP PHASE1:Hg19::chrX:140336680..140336697,-	p2@SPANXC
5.7e-21	FFCP PHASE2:Hg19::chr2:33171944..33171945,+	p15@LTBP1
5.7e-21	FFCP PHASE1:Hg19::chr2:33171944..33171945,+	p15@LTBP1
5.7e-21	FFCP PHASE2:Hg19::chr5:142000787..142000807,-	p@chr5:142000787..142000807, -
5.7e-21	FFCP PHASE1:Hg19::chr5:142000787..142000807,-	p@chr5:142000787..142000807, -
6.96e-21	FFCP PHASE2:Hg19::chr3:60761167..60761179,+	p@chr3:60761167..60761179, +
6.96e-21	FFCP PHASE1:Hg19::chr3:60761167..60761179,+	p@chr3:60761167..60761179, +
6.96e-21	FFCP PHASE1:Hg19::chr8:76774227..76774234,+	p@chr8:76774227..76774234, +
6.96e-21	FFCP PHASE2:Hg19::chr8:76774227..76774234,+	p@chr8:76774227..76774234, +
6.96e-21	FFCP PHASE1:Hg19::chr18:63273310..63273317,+	p@chr18:63273310..63273317, +
6.96e-21	FFCP PHASE2:Hg19::chr11:12061317..12061323,-	p@chr11:12061317..12061323, -
6.96e-21	FFCP PHASE1:Hg19::chr11:12061317..12061323,-	p@chr11:12061317..12061323, -
6.96e-21	FFCP PHASE2:Hg19::chr5:81611412..81611423,+	p@chr5:81611412..81611423, +
6.96e-21	FFCP PHASE2:Hg19::chr18:63273310..63273317,+	p@chr18:63273310..63273317, +
6.96e-21	FFCP PHASE1:Hg19::chr5:81611412..81611423,+	p@chr5:81611412..81611423, +
6.96e-21	FFCP PHASE2:Hg19::chr11:28792916..28792929,+	p@chr11:28792916..28792929, +
6.96e-21	FFCP PHASE1:Hg19::chr11:28792916..28792929,+	p@chr11:28792916..28792929, +

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