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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0,

Latest revision as of 11:30, 17 September 2013


Full id: C784_Endothelial_Lymphatic_Renal_placenta_Hepatic_chronic_acute



Phase1 CAGE Peaks

Hg19::chr10:59999608..59999621,-p@chr10:59999608..59999621
-
Hg19::chr10:94590857..94590871,+p4@EXOC6
Hg19::chr10:94590876..94590889,+p6@EXOC6
Hg19::chr10:94590895..94590905,+p8@EXOC6
Hg19::chr10:94590910..94590942,+p3@EXOC6
Hg19::chr10:94590950..94590955,+p13@EXOC6
Hg19::chr10:94590997..94591006,+p11@EXOC6
Hg19::chr10:94591023..94591034,+p7@EXOC6
Hg19::chr12:96841308..96841312,+p@chr12:96841308..96841312
+
Hg19::chr1:78510648..78510661,+p7@GIPC2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0000145exocyst0.0153556442645342
GO:0006904vesicle docking during exocytosis0.0153556442645342
GO:0048278vesicle docking0.0153556442645342
GO:0022406membrane docking0.0153556442645342
GO:0044448cell cortex part0.0153556442645342
GO:0005938cell cortex0.0181941893586753
GO:0006887exocytosis0.0270288838613802



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
blood vessel endothelium9.73e-3518
endothelium9.73e-3518
cardiovascular system endothelium9.73e-3518
simple squamous epithelium1.19e-2722
squamous epithelium7.93e-2425
vessel5.29e-1968
vasculature1.05e-1578
vascular system1.05e-1578
endothelial tube1.39e-159
arterial system endothelium1.39e-159
endothelium of artery1.39e-159
lymphatic vessel2.09e-138
lymph vasculature2.09e-138
lymphatic part of lymphoid system2.09e-138
splanchnic layer of lateral plate mesoderm1.95e-1283
epithelial tube open at both ends9.30e-1259
blood vessel9.30e-1259
blood vasculature9.30e-1259
vascular cord9.30e-1259
adult organism1.40e-11114
cardiovascular system2.23e-11109
circulatory system6.83e-11112
lymphoid system1.50e-1010
microcirculatory vessel6.89e-103
endothelium of capillary6.89e-103
capillary6.89e-103
anatomical conduit3.37e-09240
vein1.88e-089
venous blood vessel1.88e-089
venous system1.88e-089
anatomical cluster2.89e-07373
epithelial tube3.46e-07117
segment of aorta4.17e-072
thoracic aorta4.17e-072
Disease
Ontology termp-valuen
chronic leukemia1.95e-088


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.000221536
MA0004.10.380329
MA0006.10.236135
MA0007.10.363007
MA0009.10.828613
MA0014.10.0036779
MA0017.10.744788
MA0019.10.520264
MA0024.10.725404
MA0025.10.960689
MA0027.12.43535
MA0028.13.66076
MA0029.10.744375
MA0030.10.733118
MA0031.10.669876
MA0038.10.477043
MA0040.10.750125
MA0041.13.71961
MA0042.10.367902
MA0043.10.828925
MA0046.10.817858
MA0048.10.0613414
MA0050.10.368721
MA0051.10.473017
MA0052.10.753928
MA0055.10.014035
MA0056.10
MA0057.10.0580131
MA0058.10.293055
MA0059.10.291897
MA0060.10.138988
MA0061.10.118318
MA0063.10
MA0066.10.477449
MA0067.11.1435
MA0068.10.0911063
MA0069.10.814052
MA0070.10.803003
MA0071.10.440254
MA0072.10.798564
MA0073.10.000128517
MA0074.10.4723
MA0076.16.21294
MA0077.10.790956
MA0078.10.568317
MA0081.10.292043
MA0083.10.836033
MA0084.14.7526
MA0087.13.11125
MA0088.10.300184
MA0089.10
MA0090.11.54714
MA0091.10.382762
MA0092.10.347826
MA0093.10.238771
MA0095.10
MA0098.10
MA0100.10.49029
MA0101.10.241637
MA0103.10.228129
MA0105.10.0508589
MA0106.10.516528
MA0107.10.179177
MA0108.20.666881
MA0109.10
MA0111.10.33284
MA0113.13.33638
MA0114.10.174997
MA0115.11.06753
MA0116.10.182037
MA0117.10.865782
MA0119.10.277531
MA0122.10.891407
MA0124.11.0263
MA0125.10.942948
MA0130.10
MA0131.10.585907
MA0132.10
MA0133.10
MA0135.10.858623
MA0136.13.11845
MA0139.10.109245
MA0140.10.437738
MA0141.10.290336
MA0142.10.638837
MA0143.10.532484
MA0144.10.163394
MA0145.10.945459
MA0146.10.0169564
MA0147.10.184931
MA0148.14.83775
MA0149.10.428597
MA0062.28.23389
MA0035.20.437071
MA0039.20.0721026
MA0138.20.569505
MA0002.20.129981
MA0137.20.255808
MA0104.20.138396
MA0047.20.504873
MA0112.20.0329985
MA0065.20.340764
MA0150.10.315136
MA0151.10
MA0152.10.443956
MA0153.10.926242
MA0154.10.0494985
MA0155.10.030416
MA0156.111.3517
MA0157.10.612166
MA0158.10
MA0159.10.185458
MA0160.10.417847
MA0161.10
MA0162.10.00711618
MA0163.10.00405048
MA0164.10.544294
MA0080.24.48472
MA0018.20.517858
MA0099.20.444294
MA0079.20.00952548
MA0102.21.36707
MA0258.10.155735
MA0259.10.191914
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195862.992907456886080.006446587185075730.0280099479561561
ELF1#199772.980668571165280.002378202870469130.013471667277156
HEY1#2346272.8280777301740.003295391007019310.0170481147900777
JUN#3725810.01026335386916.45165515708383e-083.94961555070737e-06
SPI1#668875.743026455965913.41922598863134e-050.00067812484433473
TAF1#687272.34013240002170.01040839844348330.0386339241937289
TBP#690872.594739480967470.00558866901773640.0252716922213098



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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