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Coexpression cluster:C3453: Difference between revisions

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|tf_chipseq_enrich=E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0321307300518345
|tf_chipseq_enrich=E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0321307300518345
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}}
}}

Revision as of 16:08, 26 November 2012


Full id: C3453_Fibroblast_Smooth_Preadipocyte_aorta_Chondrocyte_spindle_mesenchymal



Phase1 CAGE Peaks

Hg19::chr14:75078847..75078857,-p10@LTBP2
Hg19::chr14:75078867..75078893,-p4@LTBP2
Hg19::chr14:75078895..75078916,-p3@LTBP2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
vasculature4.86e-2378
vascular system4.86e-2378
splanchnic layer of lateral plate mesoderm2.95e-2283
epithelial tube open at both ends5.48e-2059
blood vessel5.48e-2059
blood vasculature5.48e-2059
vascular cord5.48e-2059
vessel1.10e-1968
epithelial vesicle2.83e-1878
artery9.05e-1842
arterial blood vessel9.05e-1842
arterial system9.05e-1842
circulatory system9.08e-18112
multilaminar epithelium3.16e-1783
cardiovascular system3.77e-17109
epithelial tube9.24e-17117
dense mesenchyme tissue1.21e-1673
somite1.61e-1671
presomitic mesoderm1.61e-1671
presumptive segmental plate1.61e-1671
dermomyotome1.61e-1671
trunk paraxial mesoderm1.61e-1671
paraxial mesoderm2.82e-1672
presumptive paraxial mesoderm2.82e-1672
multi-cellular organism9.97e-16656
skeletal muscle tissue1.82e-1562
striated muscle tissue1.82e-1562
myotome1.82e-1562
muscle tissue2.53e-1564
musculature2.53e-1564
musculature of body2.53e-1564
organism subdivision5.28e-15264
systemic artery4.43e-1433
systemic arterial system4.43e-1433
anatomical system8.15e-14624
cell layer9.11e-14309
anatomical group1.42e-13625
epithelium2.90e-13306
unilaminar epithelium1.09e-12148
trunk mesenchyme2.21e-11122
surface structure2.92e-1199
mesoderm4.88e-11315
mesoderm-derived structure4.88e-11315
presumptive mesoderm4.88e-11315
mesenchyme7.61e-11160
entire embryonic mesenchyme7.61e-11160
aorta8.52e-1021
aortic system8.52e-1021
trunk1.71e-09199
anatomical conduit2.54e-09240
multi-tissue structure1.45e-08342
primary circulatory organ3.90e-0827
tissue7.51e-08773
anatomical cluster8.06e-08373
integument8.34e-0846
integumental system8.34e-0846
embryonic structure1.23e-07564
heart1.31e-0724
primitive heart tube1.31e-0724
primary heart field1.31e-0724
anterior lateral plate mesoderm1.31e-0724
heart tube1.31e-0724
heart primordium1.31e-0724
cardiac mesoderm1.31e-0724
cardiogenic plate1.31e-0724
heart rudiment1.31e-0724
developing anatomical structure3.23e-07581
germ layer3.67e-07560
germ layer / neural crest3.67e-07560
embryonic tissue3.67e-07560
presumptive structure3.67e-07560
germ layer / neural crest derived structure3.67e-07560
epiblast (generic)3.67e-07560
embryo6.13e-07592
organ component layer7.50e-0766
Disease
Ontology termp-valuen
ovarian cancer6.31e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187635.017155731697390.00791769806886330.0321307300518345



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.