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Coexpression cluster:C2822: Difference between revisions

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|tf_chipseq_enrich=TAF1#6872;4:3.34304628574529:0.00800566489870165:0.0323131840137392
|tf_chipseq_enrich=TAF1#6872;4:3.34304628574529:0.00800566489870165:0.0323131840137392
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}}
}}

Revision as of 15:44, 26 November 2012


Full id: C2822_Neural_Astrocyte_kidney_mesodermal_H9_cerebellum_Neurons



Phase1 CAGE Peaks

Hg19::chr5:5140200..5140232,-p1@ENST00000512155
Hg19::chr5:5140408..5140419,+p4@ADAMTS16
Hg19::chr5:5140436..5140450,+p2@ADAMTS16
Hg19::chr5:5140462..5140482,+p3@ADAMTS16


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
neuronal stem cell3.10e-148
neuron7.39e-116
neuroblast7.39e-116
electrically signaling cell7.39e-116
neural cell2.65e-1025
embryonic stem cell1.17e-095
oligodendrocyte1.17e-097
macroglial cell1.17e-097
astrocyte1.17e-097
oligodendrocyte precursor cell1.17e-097
Uber Anatomy
Ontology termp-valuen
central nervous system4.75e-3081
nervous system1.24e-2589
regional part of nervous system7.26e-2353
regional part of brain7.26e-2353
neural tube7.57e-2356
neural rod7.57e-2356
future spinal cord7.57e-2356
neural keel7.57e-2356
adult organism1.80e-20114
cerebral cortex2.49e-1925
pallium2.49e-1925
brain3.68e-1968
future brain3.68e-1968
telencephalon4.12e-1934
cerebral hemisphere5.57e-1932
neural plate6.35e-1982
presumptive neural plate6.35e-1982
neurectoderm1.68e-1786
brain grey matter3.13e-1734
gray matter3.13e-1734
regional part of telencephalon4.24e-1732
regional part of cerebral cortex4.97e-1522
regional part of forebrain1.02e-1441
forebrain1.02e-1441
anterior neural tube1.02e-1441
future forebrain1.02e-1441
organ system subdivision5.38e-14223
pre-chordal neural plate8.44e-1461
ecto-epithelium1.68e-13104
neocortex5.07e-1320
ectoderm-derived structure5.60e-13171
ectoderm5.60e-13171
presumptive ectoderm5.60e-13171
anatomical cluster5.57e-11373
structure with developmental contribution from neural crest7.80e-11132
segmental subdivision of hindbrain3.44e-1012
hindbrain3.44e-1012
presumptive hindbrain3.44e-1012
posterior neural tube1.10e-0915
chordal neural plate1.10e-0915
segmental subdivision of nervous system3.10e-0913
regional part of metencephalon5.45e-099
metencephalon5.45e-099
future metencephalon5.45e-099
male reproductive organ2.65e-0811
cerebellum4.85e-086
rhombic lip4.85e-086
embryo7.30e-08592
multi-tissue structure4.53e-07342


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
TAF1#687243.343046285745290.008005664898701650.0323131840137392



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.