Coexpression cluster:C791

Full id: C791_salivary_epididymis_submaxillary_ductus_seminal_parotid_colon

Phase1 CAGE Peaks

Hg19::chr11:111176214..111176228,-	p5@C11orf92
Hg19::chr11:70021323..70021345,-	p@chr11:70021323..70021345 -
Hg19::chr17:26800592..26800609,+	p5@SLC13A2
Hg19::chr1:1266654..1266669,+	p1@TAS1R3
Hg19::chr1:17846690..17846694,+	p11@ARHGEF10L
Hg19::chr3:46491385..46491395,-	p@chr3:46491385..46491395 -
Hg19::chr7:25702754..25702765,-	p3@ENST00000446840 p3@uc003sxp.1
Hg19::chr8:107630226..107630237,+	p18@OXR1
Hg19::chr8:107630282..107630302,+	p13@OXR1
Hg19::chr8:107630313..107630329,+	p10@OXR1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015361	low affinity sodium:dicarboxylate symporter activity	0.00513341279036033
GO:0050916	sensory perception of sweet taste	0.00513341279036033
GO:0050917	sensory perception of umami taste	0.00513341279036033
GO:0033041	sweet taste receptor activity	0.00513341279036033
GO:0001582	detection of chemical stimulus during sensory perception of sweet taste	0.00513341279036033
GO:0050907	detection of chemical stimulus during sensory perception	0.012830698841576
GO:0050912	detection of chemical stimulus during sensory perception of taste	0.012830698841576
GO:0042221	response to chemical stimulus	0.0170977803924141
GO:0008527	taste receptor activity	0.0170977803924141
GO:0017153	sodium:dicarboxylate symporter activity	0.0170977803924141
GO:0005310	dicarboxylic acid transmembrane transporter activity	0.0170977803924141
GO:0009593	detection of chemical stimulus	0.0170977803924141
GO:0016998	cell wall catabolic process	0.0170977803924141
GO:0010382	cell wall metabolic process	0.0170977803924141
GO:0007047	cell wall organization and biogenesis	0.0170977803924141
GO:0045229	external encapsulating structure organization and biogenesis	0.0176305288148319
GO:0005343	organic acid:sodium symporter activity	0.0277605898821897
GO:0015296	anion:cation symporter activity	0.0277605898821897
GO:0050909	sensory perception of taste	0.0283187928199733
GO:0050906	detection of stimulus during sensory perception	0.0294598247841548
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	0.0347493661867851
GO:0051606	detection of stimulus	0.0465069031538146
GO:0015370	solute:sodium symporter activity	0.0468551172588897
GO:0008066	glutamate receptor activity	0.0468551172588897
GO:0031402	sodium ion binding	0.0468551172588897
GO:0046943	carboxylic acid transmembrane transporter activity	0.0468551172588897
GO:0005342	organic acid transmembrane transporter activity	0.0468551172588897
GO:0046982	protein heterodimerization activity	0.0479073059231907

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	2.00e-28	114
male genital duct	3.11e-21	3
internal male genitalia	3.11e-21	3
gland of gut	2.03e-16	10
duct of male reproductive system	4.56e-16	4
major salivary gland	1.03e-14	2
open tracheal system trachea	1.89e-14	2
saliva-secreting gland	7.28e-11	6
gland of oral region	7.28e-11	6
gland of foregut	7.28e-11	6
oral gland	7.28e-11	6
oral cavity	7.28e-11	6
subdivision of digestive tract	9.42e-11	118
chordate pharynx	1.69e-10	10
pharyngeal region of foregut	1.69e-10	10
respiratory system	1.87e-10	74
male reproductive organ	4.70e-10	11
pharynx	1.48e-09	11
anatomical space	3.52e-09	95
foregut	1.47e-08	87
epididymis	2.70e-08	1
submandibular gland	2.89e-08	1
submandibular gland primordium	2.89e-08	1
orifice	2.97e-08	36
respiratory tract	2.98e-08	54
seminal vesicle	3.32e-08	1
seminal fluid secreting gland	3.32e-08	1
digestive system	3.51e-08	145
digestive tract	3.51e-08	145
primitive gut	3.51e-08	145
vas deferens	3.55e-08	1
spermatic cord	3.55e-08	1
parotid gland	3.80e-08	1
cheek	3.80e-08	1
parotid gland primordium	3.80e-08	1
lower lobe of right lung	6.52e-08	1
right lung lobe	6.52e-08	1
lower lobe of lung	6.52e-08	1
lobe of lung	6.52e-08	1
right lung	6.52e-08	1
tonsil	7.45e-08	1
mucosa-associated lymphoid tissue	7.45e-08	1
lymphoid tissue	7.45e-08	1
tonsillar ring	7.45e-08	1
uterus or analog	1.04e-07	1
male organism	1.69e-07	22
male reproductive system	1.69e-07	22
oral opening	1.82e-07	22
thymus	3.23e-07	4
hemolymphoid system gland	3.23e-07	4
thymic region	3.23e-07	4
pharyngeal gland	3.23e-07	4
thymus primordium	3.23e-07	4
endoderm-derived structure	3.95e-07	160
endoderm	3.95e-07	160
presumptive endoderm	3.95e-07	160
immaterial anatomical entity	5.39e-07	117

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
RAD21#5885	4	4.14201355818253	0.0113227647567404	0.0415289983645026

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.