Coexpression cluster:C583

Full id: C583_CD14_Monocytederived_Basophils_CD14CD16_immature_Mast_CD34

Phase1 CAGE Peaks

Hg19::chr10:80170310..80170313,+	p@chr10:80170310..80170313 +
Hg19::chr11:76476813..76476816,+	p@chr11:76476813..76476816 +
Hg19::chr12:133793193..133793194,+	p@chr12:133793193..133793194 +
Hg19::chr19:10961151..10961183,+	p@chr19:10961151..10961183 +
Hg19::chr19:55208119..55208134,+	p1@LILRP1
Hg19::chr21:44259651..44259655,+	p@chr21:44259651..44259655 +
Hg19::chr21:44259721..44259735,+	p@chr21:44259721..44259735 +
Hg19::chr2:129283966..129283970,+	p@chr2:129283966..129283970 +
Hg19::chr4:180401309..180401311,+	p@chr4:180401309..180401311 +
Hg19::chr6:1148441..1148443,+	p@chr6:1148441..1148443 +
Hg19::chr6:121899725..121899727,-	p@chr6:121899725..121899727 -
Hg19::chr9:131446139..131446175,+	p7@SET
Hg19::chrX:129812794..129812795,+	p@chrX:129812794..129812795 +
Hg19::chrX:13397469..13397486,-	p2@GPX1P1
Hg19::chrX:74494018..74494064,+	p2@UPRT

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004845	uracil phosphoribosyltransferase activity	0.00174653636327956
GO:0031057	negative regulation of histone modification	0.00174653636327956
GO:0035067	negative regulation of histone acetylation	0.00174653636327956
GO:0035065	regulation of histone acetylation	0.002619765985493
GO:0031056	regulation of histone modification	0.00314367291127999
GO:0006337	nucleosome disassembly	0.00374235758173423
GO:0031498	chromatin disassembly	0.00374235758173423
GO:0016573	histone acetylation	0.00851286095336034
GO:0042393	histone binding	0.00873088237650159
GO:0051053	negative regulation of DNA metabolic process	0.00995261980593135
GO:0006473	protein amino acid acetylation	0.00999994554258916
GO:0043624	cellular protein complex disassembly	0.0101830303727582
GO:0043241	protein complex disassembly	0.0101830303727582
GO:0032984	macromolecular complex disassembly	0.0101830303727582
GO:0043543	protein amino acid acylation	0.0101830303727582
GO:0004864	protein phosphatase inhibitor activity	0.0101830303727582
GO:0019212	phosphatase inhibitor activity	0.0101830303727582
GO:0008601	protein phosphatase type 2A regulator activity	0.0101830303727582
GO:0016570	histone modification	0.0118371805858375
GO:0051052	regulation of DNA metabolic process	0.0118371805858375
GO:0022411	cellular component disassembly	0.0118371805858375
GO:0016569	covalent chromatin modification	0.0118371805858375
GO:0051129	negative regulation of cellular component organization and biogenesis	0.0118371805858375
GO:0048471	perinuclear region of cytoplasm	0.0139593349389837
GO:0019888	protein phosphatase regulator activity	0.015893915627673
GO:0016763	transferase activity, transferring pentosyl groups	0.015893915627673
GO:0019208	phosphatase regulator activity	0.015893915627673
GO:0051128	regulation of cellular component organization and biogenesis	0.0186856225836495
GO:0051248	negative regulation of protein metabolic process	0.0187618361445914
GO:0006913	nucleocytoplasmic transport	0.0263069123921503
GO:0051169	nuclear transport	0.0263069123921503
GO:0006334	nucleosome assembly	0.0305351422457932
GO:0031497	chromatin assembly	0.0330825996670276
GO:0016568	chromatin modification	0.0336409583061555
GO:0006333	chromatin assembly or disassembly	0.0407053355428631
GO:0065004	protein-DNA complex assembly	0.0408738530891449
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0449624921352273
GO:0006260	DNA replication	0.0486939394914341

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
defensive cell	1.30e-138	48
phagocyte	1.30e-138	48
classical monocyte	2.56e-137	42
CD14-positive, CD16-negative classical monocyte	2.56e-137	42
macrophage dendritic cell progenitor	2.39e-110	61
monopoietic cell	4.84e-109	59
monocyte	4.84e-109	59
monoblast	4.84e-109	59
promonocyte	4.84e-109	59
granulocyte monocyte progenitor cell	8.72e-100	67
myeloid leukocyte	5.88e-97	72
myeloid lineage restricted progenitor cell	1.11e-96	66
stuff accumulating cell	2.59e-72	87
myeloid cell	6.33e-68	108
common myeloid progenitor	6.33e-68	108
nongranular leukocyte	2.49e-57	115
hematopoietic lineage restricted progenitor cell	2.75e-57	120
leukocyte	3.92e-57	136
hematopoietic oligopotent progenitor cell	8.46e-47	161
hematopoietic multipotent progenitor cell	8.46e-47	161
hematopoietic stem cell	1.88e-44	168
angioblastic mesenchymal cell	1.88e-44	168
hematopoietic cell	1.05e-41	177
mesenchymal cell	6.48e-16	354
connective tissue cell	2.07e-15	361
intermediate monocyte	3.08e-15	9
CD14-positive, CD16-positive monocyte	3.08e-15	9
motile cell	1.23e-13	386
non-classical monocyte	2.65e-12	3
CD14-low, CD16-positive monocyte	2.65e-12	3
stem cell	1.45e-11	441
multi fate stem cell	1.84e-11	427
somatic stem cell	3.66e-11	433

Uber Anatomy

Ontology term	p-value	n
bone marrow	5.02e-87	76
bone element	4.69e-80	82
skeletal element	3.45e-72	90
immune system	1.39e-69	93
hematopoietic system	1.36e-65	98
blood island	1.36e-65	98
skeletal system	4.16e-64	100
hemolymphoid system	1.04e-58	108
musculoskeletal system	9.44e-35	167
lateral plate mesoderm	6.22e-27	203
connective tissue	1.01e-14	371
mesoderm	5.44e-14	315
mesoderm-derived structure	5.44e-14	315
presumptive mesoderm	5.44e-14	315

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.