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Coexpression cluster:C583

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Full id: C583_CD14_Monocytederived_Basophils_CD14CD16_immature_Mast_CD34



Phase1 CAGE Peaks

Hg19::chr10:80170310..80170313,+p@chr10:80170310..80170313
+
Hg19::chr11:76476813..76476816,+p@chr11:76476813..76476816
+
Hg19::chr12:133793193..133793194,+p@chr12:133793193..133793194
+
Hg19::chr19:10961151..10961183,+p@chr19:10961151..10961183
+
Hg19::chr19:55208119..55208134,+p1@LILRP1
Hg19::chr21:44259651..44259655,+p@chr21:44259651..44259655
+
Hg19::chr21:44259721..44259735,+p@chr21:44259721..44259735
+
Hg19::chr2:129283966..129283970,+p@chr2:129283966..129283970
+
Hg19::chr4:180401309..180401311,+p@chr4:180401309..180401311
+
Hg19::chr6:1148441..1148443,+p@chr6:1148441..1148443
+
Hg19::chr6:121899725..121899727,-p@chr6:121899725..121899727
-
Hg19::chr9:131446139..131446175,+p7@SET
Hg19::chrX:129812794..129812795,+p@chrX:129812794..129812795
+
Hg19::chrX:13397469..13397486,-p2@GPX1P1
Hg19::chrX:74494018..74494064,+p2@UPRT


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004845uracil phosphoribosyltransferase activity0.00174653636327956
GO:0031057negative regulation of histone modification0.00174653636327956
GO:0035067negative regulation of histone acetylation0.00174653636327956
GO:0035065regulation of histone acetylation0.002619765985493
GO:0031056regulation of histone modification0.00314367291127999
GO:0006337nucleosome disassembly0.00374235758173423
GO:0031498chromatin disassembly0.00374235758173423
GO:0016573histone acetylation0.00851286095336034
GO:0042393histone binding0.00873088237650159
GO:0051053negative regulation of DNA metabolic process0.00995261980593135
GO:0006473protein amino acid acetylation0.00999994554258916
GO:0043624cellular protein complex disassembly0.0101830303727582
GO:0043241protein complex disassembly0.0101830303727582
GO:0032984macromolecular complex disassembly0.0101830303727582
GO:0043543protein amino acid acylation0.0101830303727582
GO:0004864protein phosphatase inhibitor activity0.0101830303727582
GO:0019212phosphatase inhibitor activity0.0101830303727582
GO:0008601protein phosphatase type 2A regulator activity0.0101830303727582
GO:0016570histone modification0.0118371805858375
GO:0051052regulation of DNA metabolic process0.0118371805858375
GO:0022411cellular component disassembly0.0118371805858375
GO:0016569covalent chromatin modification0.0118371805858375
GO:0051129negative regulation of cellular component organization and biogenesis0.0118371805858375
GO:0048471perinuclear region of cytoplasm0.0139593349389837
GO:0019888protein phosphatase regulator activity0.015893915627673
GO:0016763transferase activity, transferring pentosyl groups0.015893915627673
GO:0019208phosphatase regulator activity0.015893915627673
GO:0051128regulation of cellular component organization and biogenesis0.0186856225836495
GO:0051248negative regulation of protein metabolic process0.0187618361445914
GO:0006913nucleocytoplasmic transport0.0263069123921503
GO:0051169nuclear transport0.0263069123921503
GO:0006334nucleosome assembly0.0305351422457932
GO:0031497chromatin assembly0.0330825996670276
GO:0016568chromatin modification0.0336409583061555
GO:0006333chromatin assembly or disassembly0.0407053355428631
GO:0065004protein-DNA complex assembly0.0408738530891449
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0449624921352273
GO:0006260DNA replication0.0486939394914341



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
defensive cell1.30e-13848
phagocyte1.30e-13848
classical monocyte2.56e-13742
CD14-positive, CD16-negative classical monocyte2.56e-13742
macrophage dendritic cell progenitor2.39e-11061
monopoietic cell4.84e-10959
monocyte4.84e-10959
monoblast4.84e-10959
promonocyte4.84e-10959
granulocyte monocyte progenitor cell8.72e-10067
myeloid leukocyte5.88e-9772
myeloid lineage restricted progenitor cell1.11e-9666
stuff accumulating cell2.59e-7287
myeloid cell6.33e-68108
common myeloid progenitor6.33e-68108
nongranular leukocyte2.49e-57115
hematopoietic lineage restricted progenitor cell2.75e-57120
leukocyte3.92e-57136
hematopoietic oligopotent progenitor cell8.46e-47161
hematopoietic multipotent progenitor cell8.46e-47161
hematopoietic stem cell1.88e-44168
angioblastic mesenchymal cell1.88e-44168
hematopoietic cell1.05e-41177
mesenchymal cell6.48e-16354
connective tissue cell2.07e-15361
intermediate monocyte3.08e-159
CD14-positive, CD16-positive monocyte3.08e-159
motile cell1.23e-13386
non-classical monocyte2.65e-123
CD14-low, CD16-positive monocyte2.65e-123
stem cell1.45e-11441
multi fate stem cell1.84e-11427
somatic stem cell3.66e-11433
Uber Anatomy
Ontology termp-valuen
bone marrow5.02e-8776
bone element4.69e-8082
skeletal element3.45e-7290
immune system1.39e-6993
hematopoietic system1.36e-6598
blood island1.36e-6598
skeletal system4.16e-64100
hemolymphoid system1.04e-58108
musculoskeletal system9.44e-35167
lateral plate mesoderm6.22e-27203
connective tissue1.01e-14371
mesoderm5.44e-14315
mesoderm-derived structure5.44e-14315
presumptive mesoderm5.44e-14315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.758598
MA0004.10.711841
MA0006.10.137644
MA0007.10.241375
MA0009.11.6063
MA0014.10.142864
MA0017.11.52535
MA0019.10.990457
MA0024.10.570967
MA0025.10.796882
MA0027.12.25966
MA0028.10.454219
MA0029.10.588958
MA0030.10.578277
MA0031.10.518602
MA0038.10.34128
MA0040.10.594421
MA0041.10.27117
MA0042.10.245557
MA0043.10.669676
MA0046.10.659066
MA0048.10.0932165
MA0050.10.246257
MA0051.10.337676
MA0052.10.598036
MA0055.10.120131
MA0056.10
MA0057.10.219783
MA0058.10.538866
MA0059.10.536577
MA0060.10.237888
MA0061.11.17249
MA0063.10
MA0066.10.341645
MA0067.10.975379
MA0068.10.616525
MA0069.10.655419
MA0070.10.644843
MA0071.10.308534
MA0072.10.640598
MA0073.10.0104193
MA0074.10.337035
MA0076.10.194691
MA0077.10.633326
MA0078.10.424186
MA0081.10.18212
MA0083.10.676499
MA0084.11.15904
MA0087.10.63829
MA0088.10.11669
MA0089.10
MA0090.10.205547
MA0091.10.258318
MA0092.10.228476
MA0093.10.431889
MA0095.10
MA0098.10
MA0100.10.353174
MA0101.10.437519
MA0103.10.815939
MA0105.10.074747
MA0106.10.37688
MA0107.10.650533
MA0108.20.515791
MA0109.10
MA0111.10.617603
MA0113.10.39123
MA0114.11.06224
MA0115.10.900969
MA0116.10.320986
MA0117.10.705104
MA0119.10.170362
MA0122.10.729811
MA0124.10.860724
MA0125.10.779672
MA0130.10
MA0131.10.440395
MA0132.10
MA0133.10
MA0135.10.698212
MA0136.10.347318
MA0139.10.0481205
MA0140.10.30631
MA0141.10.180729
MA0142.11.2271
MA0143.11.79503
MA0144.10.596391
MA0145.10.135956
MA0146.10.0082386
MA0147.10.670164
MA0148.10.276339
MA0149.10.298252
MA0062.20.425026
MA0035.20.305721
MA0039.20.00733764
MA0138.21.91075
MA0002.20.220677
MA0137.20.153033
MA0104.20.236755
MA0047.20.366327
MA0112.20.692762
MA0065.22.27469
MA0150.10.582537
MA0151.10
MA0152.10.311809
MA0153.10.763487
MA0154.11.67512
MA0155.10.6552
MA0156.10.469333
MA0157.10.46471
MA0158.10
MA0159.11.11468
MA0160.11.43316
MA0161.10
MA0162.10.0634394
MA0163.10.0031263
MA0164.10.402162
MA0080.21.3752
MA0018.20.378086
MA0099.20.839067
MA0079.20.0131949
MA0102.21.1957
MA0258.10.964206
MA0259.10.104286
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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