Coexpression cluster:C2703

Full id: C2703_Reticulocytes_acute_chronic_Whole_blood_liver_CD34

Phase1 CAGE Peaks

Hg19::chr2:62523382..62523391,+	p@chr2:62523382..62523391 +
Hg19::chr2:62523413..62523427,+	p@chr2:62523413..62523427 +
Hg19::chr2:62523430..62523448,+	p@chr2:62523430..62523448 +
Hg19::chr9:132641624..132641647,+	p6@USP20

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
myeloid cell	3.95e-16	112
common myeloid progenitor	3.95e-16	112
histamine secreting cell	1.27e-14	5
biogenic amine secreting cell	1.27e-14	5
granulocytopoietic cell	1.27e-14	5
mast cell	1.27e-14	5
mast cell progenitor	1.27e-14	5
basophil mast progenitor cell	1.27e-14	5
hematopoietic stem cell	3.75e-11	172
angioblastic mesenchymal cell	3.75e-11	172
hematopoietic cell	4.33e-10	182
hematopoietic oligopotent progenitor cell	2.30e-09	165
hematopoietic multipotent progenitor cell	2.30e-09	165
endocrine cell	5.75e-08	9
erythroid lineage cell	8.33e-08	2
erythroblast	8.33e-08	2
megakaryocyte-erythroid progenitor cell	8.33e-08	2
erythroid progenitor cell	8.33e-08	2
reticulocyte	8.33e-08	2
proerythroblast	8.33e-08	2
basophilic erythroblast	8.33e-08	2
polychromatophilic erythroblast	8.33e-08	2
orthochromatic erythroblast	8.33e-08	2

Uber Anatomy

Ontology term	p-value	n
blood	5.11e-23	15
haemolymphatic fluid	5.11e-23	15
organism substance	5.11e-23	15
hematopoietic system	2.89e-09	102
blood island	2.89e-09	102
hemolymphoid system	8.25e-09	112

Disease

Ontology term	p-value	n
myeloid leukemia	1.05e-21	31
chronic leukemia	3.03e-18	8
leukemia	2.20e-16	39
hematologic cancer	1.44e-11	51
immune system cancer	1.44e-11	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	4.75215118272197	0.0138620699668949	0.0487339928391468
EP300#2033	4	6.7739417262232	0.000474845982144264	0.00434716335283703
GATA1#2623	4	13.5603081438004	2.95627390049268e-05	0.000614673083602538
GATA2#2624	4	12.744931733554	3.78864877853583e-05	0.000722840134785356
GTF2B#2959	3	23.9578724507432	0.000119775456285592	0.00162478619028587
HDAC2#3066	4	13.4156202366263	3.0859005065161e-05	0.000627752947019936
HEY1#23462	4	4.04011104310571	0.0037530463691798	0.0186392320010828
HMGN3#9324	3	6.13391079251294	0.00664069668332472	0.0283057595669639
JUND#3727	3	5.24599795640327	0.0104343275174842	0.0387054069116865
MXI1#4601	4	9.9615716287593	0.000101522475495045	0.00142588835640492
SMARCA4#6597	4	156.765903307888	1.64738581138188e-09	1.44580946852867e-07
STAT1#6772	3	15.5299406228994	0.00043408865517555	0.00405109329442223
STAT2#6773	3	48.9478283898305	1.42094046481278e-05	0.000340370644964637
TAL1#6886	4	29.8686166774402	1.25525650806991e-06	5.04804522319265e-05
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0244669321743747
YY1#7528	4	4.91117074985386	0.0017187183805544	0.010697969422893

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.