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{{UBERON
{{UBERON
|id=UBERON:0002091
|id=UBERON:0002091
|name=appendicular skeleton
|name=entire appendicular skeleton
|namespace=
|namespace=
|def="Subdivision of skeleton which consists of the total set of bones of the upper and lower limbs/appendages[WP,cjm]." [Wikipedia:Appendicular_skeleton]
|def="Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." [UBERON:cjm, UBERONREF:0000003, Wikipedia:Appendicular_skeleton]
|xref=AAO:0000747;;EFO:0000951;;FMA:71222;;MA:0000290;;MAT:0000278;;MIAA:0000278;;ncithesaurus:Appendicular_Skeleton;;SCTID:322050006;;TAO:0000027;;VAO:0000076;;XAO:0003166;;ZFA:0000027
|xref=AAO:0000747;;EFO:0000951;;FMA:71222;;http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg;;MA:0000290;;MAT:0000278;;MIAA:0000278;;ncithesaurus:Appendicular_Skeleton;;SCTID:322050006;;TAO:0000027;;VSAO:0000076;;XAO:0003166;;ZFA:0000027
|is_a=UBERON:0000075
|is_a=UBERON:0010912
|synonym="paired fin skeleton" NARROW SENSU []
|synonym="appendicular skeleton" EXACT [];;"paired fin skeleton" NARROW SENSU [];;"skeleton appendiculare" RELATED LATIN [Wikipedia:Appendicular_skeleton]
|comment=Note that ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved. Note also the FMA, confusingly, has a class appendicular skeletal system, which includes the upper and lower skeletal system as subtypes
|comment=Note that ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved.
|alt_id=UBERON:FMA_71222-MA_0000290-MIAA_0000278-ZFA_0000027
|alt_id=UBERON:FMA_71222-MA_0000290-MIAA_0000278-ZFA_0000027
|disjoint_from=
|disjoint_from=
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|obo_creation_date=
|obo_creation_date=
|subset=uberon_slim;;vertebrate_core
|subset=uberon_slim;;vertebrate_core
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
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|located_in=
|located_in=
|part_of=
|part_of=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Skeletal subdivision consisting of the paired fin or limb skeletal appendages.[VSAO]" xsd:string;;UBPROP:0000001 "Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO]" xsd:string;;UBPROP:0000001 "The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO]" xsd:string
|is_obsolete=
|is_obsolete=
|preceded_by=
|preceded_by=
}}
}}

Revision as of 17:01, 26 June 2012

Name:entire appendicular skeleton
Definition:"Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." [UBERON:cjm, UBERONREF:0000003, Wikipedia:Appendicular_skeleton]
Xrefs:
links:

AAO:0000747
EFO:0000951
FMA:71222
[1]
MA:0000290
MAT:0000278
MIAA:0000278
ncithesaurus:Appendicular_Skeleton
SCTID:322050006
TAO:0000027
VSAO:0000076
XAO:0003166

ZFA:0000027
Synonyms: "appendicular skeleton" EXACT []
"paired fin skeleton" NARROW SENSU []
"skeleton appendiculare" RELATED LATIN [Wikipedia:Appendicular_skeleton]
Comments:Note that ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved.
Alt_id: UBERON:FMA_71222-MA_0000290-MIAA_0000278-ZFA_0000027
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:UBERON:0010912(subdivision of skeleton)



Children

part of:UBERON:0002495 (long bone),UBERON:0010712 (limb skeleton subdivision),UBERON:0010740 (bone of appendage girdle complex),UBERON:0010742 (bone of pelvic complex),UBERON:0010881 (limb cartilage element),UBERON:0010882 (limb bone pre-cartilage condensation),UBERON:0011582 (paired limb/fin skeleton),UBERON:0012476 (skeleton of pelvic complex)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology


Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002091 (entire appendicular skeleton), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data


P-valueFFCPShort description
3.4e-49FFCP PHASE1:Mm9::chr11:77624716..77624729,+#_f73cfbfa1b07087029ff46352c9c1358p26@Myo18a
3.4e-49FFCP PHASE2:Mm9::chr11:77624716..77624729,+#_f73cfbfa1b07087029ff46352c9c1358p26@Myo18a
4.96e-49FFCP PHASE2:Mm9::chr2:32482372..32482381,+#_057d6e873bf0f424175d14980d98876ep@chr2:32482372..32482381, +
4.96e-49FFCP PHASE2:Mm9::chr9:21934585..21934591,-#_057d6e873bf0f424175d14980d98876ep@chr9:21934585..21934591, -
4.96e-49FFCP PHASE1:Mm9::chr8:75097542..75097549,+#_057d6e873bf0f424175d14980d98876ep@chr8:75097542..75097549, +
4.96e-49FFCP PHASE1:Mm9::chr2:32482372..32482381,+#_057d6e873bf0f424175d14980d98876ep@chr2:32482372..32482381, +
4.96e-49FFCP PHASE2:Mm9::chr8:75097542..75097549,+#_057d6e873bf0f424175d14980d98876ep@chr8:75097542..75097549, +
4.96e-49FFCP PHASE1:Mm9::chr9:21934585..21934591,-#_057d6e873bf0f424175d14980d98876ep@chr9:21934585..21934591, -
3.15e-44FFCP PHASE2:Mm9::chr6:51525810..51525817,+#_d6f15d81fbbd2718729961da22504a9dp@chr6:51525810..51525817, +
3.15e-44FFCP PHASE1:Mm9::chr6:51525810..51525817,+#_d6f15d81fbbd2718729961da22504a9dp@chr6:51525810..51525817, +
9.78e-40FFCP PHASE1:Mm9::chr19:4876870..4876880,-#_0ca45fb336d18077e3a1ec148f47d577p@chr19:4876870..4876880, -
9.78e-40FFCP PHASE2:Mm9::chr19:4876870..4876880,-#_0ca45fb336d18077e3a1ec148f47d577p@chr19:4876870..4876880, -
1.15e-39FFCP PHASE1:Mm9::chr1:174140324..174140335,-#_ae059f7786c8378b717a3109bdd3ab12p@chr1:174140324..174140335, -
1.15e-39FFCP PHASE2:Mm9::chr11:67063327..67063335,+#_ae059f7786c8378b717a3109bdd3ab12p@chr11:67063327..67063335, +
1.15e-39FFCP PHASE1:Mm9::chr16:24096441..24096449,+#_ae059f7786c8378b717a3109bdd3ab12p@chr16:24096441..24096449, +
1.15e-39FFCP PHASE1:Mm9::chr6:4490674..4490679,+#_ae059f7786c8378b717a3109bdd3ab12p@chr6:4490674..4490679, +
1.15e-39FFCP PHASE2:Mm9::chr6:4490674..4490679,+#_ae059f7786c8378b717a3109bdd3ab12p@chr6:4490674..4490679, +
1.15e-39FFCP PHASE1:Mm9::chr11:67063327..67063335,+#_ae059f7786c8378b717a3109bdd3ab12p@chr11:67063327..67063335, +
1.15e-39FFCP PHASE2:Mm9::chr16:24096441..24096449,+#_ae059f7786c8378b717a3109bdd3ab12p@chr16:24096441..24096449, +
1.15e-39FFCP PHASE2:Mm9::chr1:174140324..174140335,-#_ae059f7786c8378b717a3109bdd3ab12p@chr1:174140324..174140335, -
1.55e-39FFCP PHASE1:Mm9::chr1:174143249..174143260,-#_4fe09402e7c4752dab6e6fd0ff3c7770p@chr1:174143249..174143260, -
1.55e-39FFCP PHASE2:Mm9::chr1:174143249..174143260,-#_4fe09402e7c4752dab6e6fd0ff3c7770p@chr1:174143249..174143260, -
3.03e-39FFCP PHASE1:Mm9::chr6:51525869..51525891,+#_7629cf08ab541e3f9e10f4d0b157262dp@chr6:51525869..51525891, +
3.03e-39FFCP PHASE2:Mm9::chr6:51525869..51525891,+#_7629cf08ab541e3f9e10f4d0b157262dp@chr6:51525869..51525891, +
9.31e-39FFCP PHASE1:Mm9::chr11:102130083..102130092,+#_659ef86004fd892a929c06d23ab08b53p3@Asb16
9.31e-39FFCP PHASE2:Mm9::chr11:102130083..102130092,+#_659ef86004fd892a929c06d23ab08b53p3@Asb16
2.41e-35FFCP PHASE1:Mm9::chr7:133604286..133604297,-#_cf26d96b7e6c6111b14c111a52f55f0ap@chr7:133604286..133604297, -
2.41e-35FFCP PHASE2:Mm9::chr7:133604286..133604297,-#_cf26d96b7e6c6111b14c111a52f55f0ap@chr7:133604286..133604297, -
2.95e-35FFCP PHASE2:Mm9::chr4:138365748..138365759,-#_d1135ed66d6887cd2be3d041b84e8169p5@Pla2g5
2.95e-35FFCP PHASE1:Mm9::chr4:138365748..138365759,-#_d1135ed66d6887cd2be3d041b84e8169p5@Pla2g5
9.53e-34FFCP PHASE2:Mm9::chr8:74049600..74049612,-#_6cd9cc18d3666d06c0d30e476ea3fcb9p2@uc009mdq.1
9.53e-34FFCP PHASE1:Mm9::chr8:74049600..74049612,-#_6cd9cc18d3666d06c0d30e476ea3fcb9p2@uc009mdq.1
1.23e-33FFCP PHASE2:Mm9::chr2:164773241..164773248,+#_86fffeb612273beb8734d88f7ba9a137p3@Mmp9
1.23e-33FFCP PHASE1:Mm9::chr2:164773241..164773248,+#_86fffeb612273beb8734d88f7ba9a137p3@Mmp9
1.58e-33FFCP PHASE1:Mm9::chr7:3567707..3567718,-#_54c990d7becef63491bcce7edeb1e1fcp2@Oscar
1.58e-33FFCP PHASE2:Mm9::chr7:3567707..3567718,-#_54c990d7becef63491bcce7edeb1e1fcp2@Oscar
1.58e-33FFCP PHASE2:Mm9::chr1:166815111..166815121,-#_54c990d7becef63491bcce7edeb1e1fcp@chr1:166815111..166815121, -
1.58e-33FFCP PHASE1:Mm9::chr1:166815111..166815121,-#_54c990d7becef63491bcce7edeb1e1fcp@chr1:166815111..166815121, -
2.04e-33FFCP PHASE2:Mm9::chr11:75409652..75409664,+#_bebc21d5ba152c249146b1b6dc9fe6bfp@chr11:75409652..75409664, +
2.04e-33FFCP PHASE1:Mm9::chr9:70799951..70799962,-#_bebc21d5ba152c249146b1b6dc9fe6bfp4@Lipc
2.04e-33FFCP PHASE2:Mm9::chr9:70799951..70799962,-#_bebc21d5ba152c249146b1b6dc9fe6bfp4@Lipc
2.04e-33FFCP PHASE1:Mm9::chr11:75409652..75409664,+#_bebc21d5ba152c249146b1b6dc9fe6bfp@chr11:75409652..75409664, +
3.38e-33FFCP PHASE1:Mm9::chr15:102196702..102196713,-#_b7cc4b51f3f3b9251ce3c2416d7d1477p6@Sp7
3.38e-33FFCP PHASE2:Mm9::chr15:102196702..102196713,-#_b7cc4b51f3f3b9251ce3c2416d7d1477p6@Sp7
7.17e-33FFCP PHASE2:Mm9::chr18:76271498..76271508,+#_f2308f28212c8ec23b39b9019c965e18p@chr18:76271498..76271508, +
7.17e-33FFCP PHASE1:Mm9::chr8:126415826..126415839,+#_f2308f28212c8ec23b39b9019c965e18p@chr8:126415826..126415839, +
7.17e-33FFCP PHASE2:Mm9::chr8:126415826..126415839,+#_f2308f28212c8ec23b39b9019c965e18p@chr8:126415826..126415839, +
7.17e-33FFCP PHASE1:Mm9::chr18:76271498..76271508,+#_f2308f28212c8ec23b39b9019c965e18p@chr18:76271498..76271508, +
2.67e-30FFCP PHASE2:Mm9::chr2:32482387..32482399,+#_39a26da5625fec8cf90ec8cb7997af04p@chr2:32482387..32482399, +
2.67e-30FFCP PHASE1:Mm9::chr2:32482387..32482399,+#_39a26da5625fec8cf90ec8cb7997af04p@chr2:32482387..32482399, +
1.1e-29FFCP PHASE2:Mm9::chr12:70396969..70396979,+#_eda6d043f3ce88e1a7541cd462edd257p@chr12:70396969..70396979, +
1.1e-29FFCP PHASE1:Mm9::chr12:70396969..70396979,+#_eda6d043f3ce88e1a7541cd462edd257p@chr12:70396969..70396979, +
1.1e-29FFCP PHASE2:Mm9::chr15:58649683..58649688,-#_eda6d043f3ce88e1a7541cd462edd257p@chr15:58649683..58649688, -
1.1e-29FFCP PHASE1:Mm9::chr15:58649683..58649688,-#_eda6d043f3ce88e1a7541cd462edd257p@chr15:58649683..58649688, -
1.46e-29FFCP PHASE1:Mm9::chr7:133590998..133591009,-#_53f3d788df95943d76c5e6c52937a2acp@chr7:133590998..133591009, -
1.46e-29FFCP PHASE2:Mm9::chr7:133590998..133591009,-#_53f3d788df95943d76c5e6c52937a2acp@chr7:133590998..133591009, -
1.73e-29FFCP PHASE2:Mm9::chr18:60751417..60751432,-#_bfccd1413aec515f183203b8c7b25d18p2@Myoz3
1.73e-29FFCP PHASE1:Mm9::chr18:60751417..60751432,-#_bfccd1413aec515f183203b8c7b25d18p2@Myoz3
2.42e-29FFCP PHASE2:Mm9::chr11:67051354..67051366,+#_a4ed214ea959149798e121629882a5f0p2@Myh4
2.42e-29FFCP PHASE1:Mm9::chr11:67051354..67051366,+#_a4ed214ea959149798e121629882a5f0p2@Myh4
7.46e-29FFCP PHASE1:Mm9::chr1:57155729..57155740,-#_cbc4f45b969673af746b5d00bc9ae83bp@chr1:57155729..57155740, -
7.46e-29FFCP PHASE2:Mm9::chr1:57155729..57155740,-#_cbc4f45b969673af746b5d00bc9ae83bp@chr1:57155729..57155740, -
9.26e-29FFCP PHASE1:Mm9::chr11:67056544..67056589,-#_a1185a82824efb222c3721c7d94150dcp@chr11:67056544..67056589, -
9.26e-29FFCP PHASE1:Mm9::chr4:43597258..43597265,-#_a1185a82824efb222c3721c7d94150dcp1@Msmp
9.26e-29FFCP PHASE2:Mm9::chr11:67056544..67056589,-#_a1185a82824efb222c3721c7d94150dcp@chr11:67056544..67056589, -
9.26e-29FFCP PHASE2:Mm9::chr4:43597258..43597265,-#_a1185a82824efb222c3721c7d94150dcp1@Msmp
1.15e-28FFCP PHASE2:Mm9::chrY:2858251..2858257,+#_06c623ca0adb59a922e2f0cf0914c0e5p@chrY:2858251..2858257, +
1.15e-28FFCP PHASE2:Mm9::chr6:90552017..90552024,+#_06c623ca0adb59a922e2f0cf0914c0e5p@chr6:90552017..90552024, +
1.15e-28FFCP PHASE1:Mm9::chr6:90552017..90552024,+#_06c623ca0adb59a922e2f0cf0914c0e5p@chr6:90552017..90552024, +
1.15e-28FFCP PHASE1:Mm9::chrY:2858251..2858257,+#_06c623ca0adb59a922e2f0cf0914c0e5p@chrY:2858251..2858257, +
1.43e-28FFCP PHASE1:Mm9::chr6:34436258..34436292,+#_a8b20210e7659527d11f2a17f470946dp@chr6:34436258..34436292, +
1.43e-28FFCP PHASE2:Mm9::chr6:34436258..34436292,+#_a8b20210e7659527d11f2a17f470946dp@chr6:34436258..34436292, +
2.2e-28FFCP PHASE2:Mm9::chr11:67069796..67069817,-#_bf756eb690964931f03443700bac092fp@chr11:67069796..67069817, -
2.2e-28FFCP PHASE1:Mm9::chr11:67069796..67069817,-#_bf756eb690964931f03443700bac092fp@chr11:67069796..67069817, -
2.72e-28FFCP PHASE2:Mm9::chr8:107702369..107702386,+#_10f6f8597d81994ef24c0b40c8a44c45p@chr8:107702369..107702386, +
2.72e-28FFCP PHASE1:Mm9::chr8:107702369..107702386,+#_10f6f8597d81994ef24c0b40c8a44c45p@chr8:107702369..107702386, +
3.45e-28FFCP PHASE1:Mm9::chr18:78254135..78254146,-#_03ad116cf48353acde1b6685f97902f9p1@Siglec15
3.45e-28FFCP PHASE2:Mm9::chr18:78254135..78254146,-#_03ad116cf48353acde1b6685f97902f9p1@Siglec15
6.5e-28FFCP PHASE2:Mm9::chr7:133591490..133591500,-#_f894085b132c68e962b8e7fab821dadep6@Atp2a1
6.5e-28FFCP PHASE1:Mm9::chr7:133591490..133591500,-#_f894085b132c68e962b8e7fab821dadep6@Atp2a1
8.9e-28FFCP PHASE2:Mm9::chr7:133591156..133591165,-#_58179346c1496340c6c595b3b145d014p7@Atp2a1
8.9e-28FFCP PHASE1:Mm9::chr7:133591156..133591165,-#_58179346c1496340c6c595b3b145d014p7@Atp2a1
1.42e-27FFCP PHASE2:Mm9::chr7:133600635..133600663,+#_68a8637199c2930dd0c20bcd586dc7d0p@chr7:133600635..133600663, +
1.42e-27FFCP PHASE1:Mm9::chr7:133600635..133600663,+#_68a8637199c2930dd0c20bcd586dc7d0p@chr7:133600635..133600663, +
1.42e-27FFCP PHASE2:Mm9::chr7:133592162..133592188,-#_68a8637199c2930dd0c20bcd586dc7d0p@chr7:133592162..133592188, -
1.42e-27FFCP PHASE1:Mm9::chr7:133592162..133592188,-#_68a8637199c2930dd0c20bcd586dc7d0p@chr7:133592162..133592188, -
6.75e-27FFCP PHASE2:Mm9::chr11:94837662..94837673,-#_0dbcfc56036d52356f9833d0e7c3ea67p4@Sgca
6.75e-27FFCP PHASE1:Mm9::chr11:94837662..94837673,-#_0dbcfc56036d52356f9833d0e7c3ea67p4@Sgca
1.66e-26FFCP PHASE1:Mm9::chr5:104754379..104754387,+#_30295d72a0115907f5cb907c89f3246fp1@Mepe
1.66e-26FFCP PHASE2:Mm9::chr5:104754379..104754387,+#_30295d72a0115907f5cb907c89f3246fp1@Mepe
3.47e-26FFCP PHASE1:Mm9::chr16:32400888..32400899,+#_8c674277ffc3b6f7c42b5e8a2d990911p2@Tm4sf19
3.47e-26FFCP PHASE2:Mm9::chr12:81581216..81581231,+#_8c674277ffc3b6f7c42b5e8a2d990911p@chr12:81581216..81581231, +
3.47e-26FFCP PHASE1:Mm9::chr12:81581216..81581231,+#_8c674277ffc3b6f7c42b5e8a2d990911p@chr12:81581216..81581231, +
3.47e-26FFCP PHASE2:Mm9::chr16:32400888..32400899,+#_8c674277ffc3b6f7c42b5e8a2d990911p2@Tm4sf19
1.12e-25FFCP PHASE2:Mm9::chr17:34176173..34176200,+#_e378baa4e3fcca90270796a496b61ca0p5@Col11a2
1.12e-25FFCP PHASE1:Mm9::chr15:97806574..97806585,-#_e378baa4e3fcca90270796a496b61ca0p@chr15:97806574..97806585, -
1.12e-25FFCP PHASE2:Mm9::chr15:97806574..97806585,-#_e378baa4e3fcca90270796a496b61ca0p@chr15:97806574..97806585, -
1.12e-25FFCP PHASE1:Mm9::chr17:34176173..34176200,+#_e378baa4e3fcca90270796a496b61ca0p5@Col11a2
1.36e-25FFCP PHASE1:Mm9::chr2:180890942..180890956,-#_af420af95f0366303a3d8cb36dd19a1ep@chr2:180890942..180890956, -
1.36e-25FFCP PHASE1:Mm9::chr18:78254174..78254185,-#_af420af95f0366303a3d8cb36dd19a1ep2@Siglec15










Property "Property value" (as page type) with input value "UBPROP:0000001 "Skeletal subdivision consisting of the paired fin or limb skeletal appendages.[VSAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000001 "Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000001 "The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.