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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0

Latest revision as of 12:27, 17 September 2013


Full id: C3518_lymphangiectasia_lymphoma_plasma_B_CD4_xeroderma_Dendritic



Phase1 CAGE Peaks

Hg19::chr15:79271225..79271235,+p2@ENST00000316148
Hg19::chr15:81592487..81592496,+p17@IL16
Hg19::chr15:81592512..81592540,+p6@IL16


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0050930induction of positive chemotaxis0.00170728835511598
GO:0050927positive regulation of positive chemotaxis0.00170728835511598
GO:0050918positive chemotaxis0.00170728835511598
GO:0050926regulation of positive chemotaxis0.00170728835511598
GO:0050921positive regulation of chemotaxis0.00170728835511598
GO:0050920regulation of chemotaxis0.00170728835511598
GO:0030595leukocyte chemotaxis0.00280483086911911
GO:0050900leukocyte migration0.00330787118803721
GO:0042330taxis0.012292476156835
GO:0006935chemotaxis0.012292476156835
GO:0007626locomotory behavior0.014046326921636
GO:0016477cell migration0.0165749244475843
GO:0007610behavior0.0189021210744983
GO:0005125cytokine activity0.0189021210744983
GO:0051674localization of cell0.0204341075002943
GO:0006928cell motility0.0204341075002943
GO:0005615extracellular space0.0265131838676834
GO:0042221response to chemical stimulus0.0279331344767586
GO:0009605response to external stimulus0.0284398297049582
GO:0044421extracellular region part0.0388408100788885
GO:0005102receptor binding0.0421537624822683
GO:0006955immune response0.0461355875962022



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
lymphocyte of B lineage2.89e-3324
pro-B cell2.89e-3324
lymphoid lineage restricted progenitor cell2.43e-2752
lymphocyte1.00e-2653
common lymphoid progenitor1.00e-2653
nucleate cell1.48e-2555
nongranular leukocyte1.03e-15115
leukocyte6.53e-15136
hematopoietic lineage restricted progenitor cell1.63e-13120
hematopoietic stem cell7.28e-12168
angioblastic mesenchymal cell7.28e-12168
hematopoietic cell6.41e-11177
hematopoietic oligopotent progenitor cell1.54e-10161
hematopoietic multipotent progenitor cell1.54e-10161
B cell1.57e-0914
mature B cell8.31e-092
pre-B-II cell8.31e-092
transitional stage B cell8.31e-092
small pre-B-II cell8.31e-092
immature B cell8.31e-092
mature alpha-beta T cell8.60e-0718
alpha-beta T cell8.60e-0718
immature T cell8.60e-0718
mature T cell8.60e-0718
immature alpha-beta T cell8.60e-0718
Uber Anatomy
Ontology termp-valuen
hemopoietic organ1.80e-127
immune organ1.80e-127
thymus1.46e-084
hemolymphoid system gland1.46e-084
thymic region1.46e-084
pharyngeal gland1.46e-084
thymus primordium1.46e-084
Disease
Ontology termp-valuen
lymphoma3.57e-0910


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.12.26702
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.12.19699
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.12.29531
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.12.30945
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.941469
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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