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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.630449317340246

Latest revision as of 11:27, 17 September 2013


Full id: C633_Olfactory_Fibroblast_Preadipocyte_Hair_tenocyte_mesenchymal_basal



Phase1 CAGE Peaks

Hg19::chr1:215178636..215178662,+p5@KCNK2
Hg19::chr1:215178669..215178685,+p13@KCNK2
Hg19::chr1:215178693..215178706,+p28@KCNK2
Hg19::chr1:215178726..215178743,+p24@KCNK2
Hg19::chr1:215178832..215178850,+p16@KCNK2
Hg19::chr1:215178858..215178873,+p17@KCNK2
Hg19::chr1:215178875..215178906,+p2@KCNK2
Hg19::chr1:215178908..215178935,+p3@KCNK2
Hg19::chr1:215178944..215178967,+p11@KCNK2
Hg19::chr1:215179028..215179060,+p9@KCNK2
Hg19::chr1:215179111..215179149,+p4@KCNK2
Hg19::chr1:215179154..215179167,+p12@KCNK2
Hg19::chr1:215179188..215179201,+p21@KCNK2
Hg19::chr1:215202322..215202325,+p@chr1:215202322..215202325
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
integument2.65e-1646
integumental system2.65e-1646
skin of body1.40e-1541
surface structure1.70e-1299
skull4.01e-097
connective tissue1.92e-08371
artery wall2.72e-084
tunica adventitia of artery2.72e-084
adventitia2.72e-084
tunica adventitia of blood vessel2.72e-084
aorta tunica adventitia2.72e-084
aorta wall2.72e-084
periodontium5.97e-086
dentition5.97e-086
cranial skeletal system2.70e-0711
Disease
Ontology termp-valuen
musculoskeletal system disease1.63e-105
myotonic disease1.63e-105
muscle tissue disease1.63e-105
myopathy1.63e-105
muscular disease1.63e-105
myotonic dystrophy1.63e-105


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.06747e-05
MA0004.10.275994
MA0006.10.906232
MA0007.10.260673
MA0009.10.695988
MA0014.10.000542531
MA0017.10.181071
MA0019.10.403106
MA0024.10.59663
MA0025.10.824398
MA0027.12.28954
MA0028.10.164086
MA0029.110.6708
MA0030.10.604021
MA0031.10.543644
MA0038.10.363295
MA0040.11.50383
MA0041.10.291389
MA0042.10.264992
MA0043.10.69629
MA0046.11.64005
MA0048.10.0262025
MA0050.10.265714
MA0051.12.54118
MA0052.10.623986
MA0055.10.00349085
MA0056.10
MA0057.10.0243088
MA0058.10.200063
MA0059.10.199079
MA0060.10.0773489
MA0061.10.841286
MA0063.10
MA0066.10.363668
MA0067.11.00375
MA0068.10.0444239
MA0069.10.681911
MA0070.10.671241
MA0071.10.329767
MA0072.10.666958
MA0073.11.61602e-07
MA0074.10.358953
MA0076.10.212295
MA0077.10.65962
MA0078.12.95461
MA0081.10.578007
MA0083.10.703169
MA0084.11.18798
MA0087.10.664629
MA0088.10.0103438
MA0089.10
MA0090.10.223576
MA0091.10.278153
MA0092.10.247341
MA0093.10.154754
MA0095.10
MA0098.10
MA0100.13.58625
MA0101.10.1571
MA0103.10.146091
MA0105.10.0203556
MA0106.11.0329
MA0107.10.708233
MA0108.20.540797
MA0109.10
MA0111.10.234271
MA0113.16.07703
MA0114.10.104181
MA0115.10.929032
MA0116.10.10959
MA0117.10.732
MA0119.13.11614
MA0122.10.756889
MA0124.10.888592
MA0125.10.807083
MA0130.10
MA0131.10.464307
MA0132.10
MA0133.10
MA0135.10.725055
MA0136.10.369468
MA0139.10.0564547
MA0140.10.327488
MA0141.10.197753
MA0142.19.63776
MA0143.11.06513
MA0144.10.0953756
MA0145.10.0126924
MA0146.10.000361686
MA0147.10.111828
MA0148.13.09607
MA0149.10.319221
MA0062.20.0599644
MA0035.21.56986
MA0039.20.000193995
MA0138.20.44894
MA0002.20.531015
MA0137.20.168782
MA0104.20.0769208
MA0047.20.388882
MA0112.20.0113102
MA0065.20.0133095
MA0150.10.218956
MA0151.10
MA0152.13.32631
MA0153.10.790794
MA0154.10.0196232
MA0155.10.0101184
MA0156.10.170442
MA0157.11.22595
MA0158.10
MA0159.10.112236
MA0160.10.30953
MA0161.10
MA0162.10.00136062
MA0163.10.000620686
MA0164.10.425415
MA0080.20.154815
MA0018.20.400879
MA0099.20.333432
MA0079.25.24095e-11
MA0102.21.22472
MA0258.10.089643
MA0259.10.117259
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203394.354676824000633.27329906170514e-050.000651286112984231
GATA2#262498.193170400141851.56227145797145e-078.7533298711953e-06
RAD21#588596.656807504221939.27601497981902e-073.97855329970151e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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