Coexpression cluster:C51: Difference between revisions
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Latest revision as of 10:18, 17 September 2013
Full id: C51_kidney_mesothelioma_renal_signet_gall_lung_pancreas
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
0.000148919287154557 | 0.0188531817537669 | 3 | 30 | Butanoate metabolism (KEGG):00650 |
2.15700602326702e-06 | 0.000682692406364011 | 4 | 27 | Collecting duct acid secretion (KEGG):04966 |
0.000106377586992414 | 0.0168342531415496 | 4 | 71 | Bile secretion (KEGG):04976 |
3.11285026468701e-23 | 1.97043421754688e-20 | 24 | 401 | Transmembrane transport of small molecules (Reactome):REACT_15518 |
5.10046000699888e-06 | 0.00107619706147676 | 7 | 195 | Metabolism of amino acids and derivatives (Reactome):REACT_13 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006810 | transport | 1.89719617973371e-19 |
GO:0051179 | localization | 3.93254738270869e-19 |
GO:0051234 | establishment of localization | 3.93254738270869e-19 |
GO:0022857 | transmembrane transporter activity | 1.43098723909109e-18 |
GO:0006811 | ion transport | 1.39136997934498e-15 |
GO:0022891 | substrate-specific transmembrane transporter activity | 1.89100379586395e-14 |
GO:0022892 | substrate-specific transporter activity | 8.03738440540318e-14 |
GO:0031420 | alkali metal ion binding | 1.01013960965506e-13 |
GO:0016021 | integral to membrane | 2.68046580461342e-13 |
GO:0031224 | intrinsic to membrane | 3.2327410395408e-13 |
GO:0044425 | membrane part | 4.07281717433875e-13 |
GO:0015075 | ion transmembrane transporter activity | 2.85379220766244e-12 |
GO:0015672 | monovalent inorganic cation transport | 2.85379220766244e-12 |
GO:0006812 | cation transport | 4.11975453053663e-12 |
GO:0031402 | sodium ion binding | 5.13616113380487e-12 |
GO:0006814 | sodium ion transport | 6.43531045011207e-11 |
GO:0030001 | metal ion transport | 1.30786989883719e-10 |
GO:0044459 | plasma membrane part | 1.85190694845496e-10 |
GO:0016020 | membrane | 1.85190694845496e-10 |
GO:0008509 | anion transmembrane transporter activity | 4.03661278807385e-10 |
GO:0015291 | secondary active transmembrane transporter activity | 5.20103592570194e-10 |
GO:0005886 | plasma membrane | 3.34008710852286e-09 |
GO:0022804 | active transmembrane transporter activity | 9.1595968211759e-09 |
GO:0043167 | ion binding | 2.65142772349874e-07 |
GO:0005887 | integral to plasma membrane | 3.52424109253111e-07 |
GO:0031226 | intrinsic to plasma membrane | 4.07130909570118e-07 |
GO:0015293 | symporter activity | 5.21595116983373e-07 |
GO:0044464 | cell part | 1.27511387025829e-06 |
GO:0006820 | anion transport | 5.69715338490617e-06 |
GO:0005903 | brush border | 1.05808749831209e-05 |
GO:0008324 | cation transmembrane transporter activity | 1.31588749889808e-05 |
GO:0043169 | cation binding | 2.32484834710577e-05 |
GO:0015103 | inorganic anion transmembrane transporter activity | 3.15671049247844e-05 |
GO:0046872 | metal ion binding | 3.15671049247844e-05 |
GO:0031526 | brush border membrane | 3.45096951005187e-05 |
GO:0022838 | substrate specific channel activity | 4.82877500825496e-05 |
GO:0030955 | potassium ion binding | 4.89228184140082e-05 |
GO:0022803 | passive transmembrane transporter activity | 5.04803506897739e-05 |
GO:0015267 | channel activity | 5.04803506897739e-05 |
GO:0031253 | cell projection membrane | 5.90860453867758e-05 |
GO:0007588 | excretion | 9.41706039515223e-05 |
GO:0005737 | cytoplasm | 0.00012926674808703 |
GO:0032387 | negative regulation of intracellular transport | 0.000130581945692104 |
GO:0044463 | cell projection part | 0.000138426034225713 |
GO:0005216 | ion channel activity | 0.000238729155266518 |
GO:0005624 | membrane fraction | 0.000239502793378283 |
GO:0022832 | voltage-gated channel activity | 0.000421895053557396 |
GO:0005244 | voltage-gated ion channel activity | 0.000421895053557396 |
GO:0015184 | L-cystine transmembrane transporter activity | 0.000671477741104918 |
GO:0000099 | sulfur amino acid transmembrane transporter activity | 0.000671477741104918 |
GO:0006813 | potassium ion transport | 0.00100475911406071 |
GO:0015380 | anion exchanger activity | 0.00114743274626435 |
GO:0005452 | inorganic anion exchanger activity | 0.00114743274626435 |
GO:0015106 | bicarbonate transmembrane transporter activity | 0.00114743274626435 |
GO:0015301 | anion:anion antiporter activity | 0.00124073130270833 |
GO:0015108 | chloride transmembrane transporter activity | 0.0013378660241174 |
GO:0015297 | antiporter activity | 0.00146501519497426 |
GO:0000267 | cell fraction | 0.00192889604716405 |
GO:0015849 | organic acid transport | 0.00192889604716405 |
GO:0005342 | organic acid transmembrane transporter activity | 0.00192889604716405 |
GO:0015296 | anion:cation symporter activity | 0.0020337718654762 |
GO:0015294 | solute:cation symporter activity | 0.0032104410204545 |
GO:0008514 | organic anion transmembrane transporter activity | 0.0038938818649058 |
GO:0022836 | gated channel activity | 0.00494353702542133 |
GO:0015114 | phosphate transmembrane transporter activity | 0.00746998368263885 |
GO:0015171 | amino acid transmembrane transporter activity | 0.00757174694582507 |
GO:0015698 | inorganic anion transport | 0.00766565248542183 |
GO:0016324 | apical plasma membrane | 0.0091944362799982 |
GO:0051180 | vitamin transport | 0.00926356720720928 |
GO:0006865 | amino acid transport | 0.00972659221552472 |
GO:0005261 | cation channel activity | 0.00991757399722957 |
GO:0016998 | cell wall catabolic process | 0.0126001088003563 |
GO:0010382 | cell wall metabolic process | 0.0136082325506414 |
GO:0007047 | cell wall organization and biogenesis | 0.0136082325506414 |
GO:0005739 | mitochondrion | 0.0141096244591854 |
GO:0005254 | chloride channel activity | 0.0141967554264155 |
GO:0005212 | structural constituent of eye lens | 0.0144446117554799 |
GO:0015837 | amine transport | 0.014836119494306 |
GO:0042995 | cell projection | 0.0148972277812976 |
GO:0016323 | basolateral plasma membrane | 0.0149752398052477 |
GO:0045229 | external encapsulating structure organization and biogenesis | 0.0150973130621619 |
GO:0045177 | apical part of cell | 0.0151182338322654 |
GO:0006821 | chloride transport | 0.0153250566806487 |
GO:0005509 | calcium ion binding | 0.0153250566806487 |
GO:0032386 | regulation of intracellular transport | 0.0186090828564014 |
GO:0046873 | metal ion transmembrane transporter activity | 0.0196627119797523 |
GO:0005242 | inward rectifier potassium channel activity | 0.0196627119797523 |
GO:0046943 | carboxylic acid transmembrane transporter activity | 0.0196627119797523 |
GO:0046942 | carboxylic acid transport | 0.0196627119797523 |
GO:0005253 | anion channel activity | 0.0196627119797523 |
GO:0005267 | potassium channel activity | 0.0196627119797523 |
GO:0048611 | embryonic ectodermal gut development | 0.0196627119797523 |
GO:0048613 | embryonic ectodermal gut morphogenesis | 0.0196627119797523 |
GO:0046874 | quinolinate metabolic process | 0.0196627119797523 |
GO:0005362 | low-affinity glucose:sodium symporter activity | 0.0196627119797523 |
GO:0004530 | deoxyribonuclease I activity | 0.0196627119797523 |
GO:0001760 | aminocarboxymuconate-semialdehyde decarboxylase activity | 0.0196627119797523 |
GO:0046950 | ketone body metabolic process | 0.0196627119797523 |
GO:0015747 | urate transport | 0.0196627119797523 |
GO:0047305 | (R)-3-amino-2-methylpropionate-pyruvate transaminase activity | 0.0196627119797523 |
GO:0051657 | maintenance of organelle localization | 0.0196627119797523 |
GO:0004230 | glutamyl aminopeptidase activity | 0.0196627119797523 |
GO:0051659 | maintenance of mitochondrion localization | 0.0196627119797523 |
GO:0015143 | urate transmembrane transporter activity | 0.0196627119797523 |
GO:0007443 | Malpighian tubule morphogenesis | 0.0196627119797523 |
GO:0008267 | poly-glutamine tract binding | 0.0196627119797523 |
GO:0048619 | embryonic hindgut morphogenesis | 0.0196627119797523 |
GO:0051051 | negative regulation of transport | 0.0223754260837359 |
GO:0006805 | xenobiotic metabolic process | 0.0223754260837359 |
GO:0043066 | negative regulation of apoptosis | 0.0228738368156062 |
GO:0015179 | L-amino acid transmembrane transporter activity | 0.0234044345150818 |
GO:0043069 | negative regulation of programmed cell death | 0.023550953896321 |
GO:0046903 | secretion | 0.0253474760918795 |
GO:0009410 | response to xenobiotic stimulus | 0.0256984774904907 |
GO:0044444 | cytoplasmic part | 0.0273494201605538 |
GO:0005247 | voltage-gated chloride channel activity | 0.0324182986052347 |
GO:0019752 | carboxylic acid metabolic process | 0.0324182986052347 |
GO:0006855 | multidrug transport | 0.0324182986052347 |
GO:0008260 | 3-oxoacid CoA-transferase activity | 0.0324182986052347 |
GO:0000101 | sulfur amino acid transport | 0.0324182986052347 |
GO:0048558 | embryonic gut morphogenesis | 0.0324182986052347 |
GO:0019826 | oxygen sensor activity | 0.0324182986052347 |
GO:0016139 | glycoside catabolic process | 0.0324182986052347 |
GO:0008511 | sodium:potassium:chloride symporter activity | 0.0324182986052347 |
GO:0048557 | embryonic digestive tract morphogenesis | 0.0324182986052347 |
GO:0043072 | negative regulation of non-apoptotic programmed cell death | 0.0324182986052347 |
GO:0005412 | glucose:sodium symporter activity | 0.0324182986052347 |
GO:0016137 | glycoside metabolic process | 0.0324182986052347 |
GO:0008336 | gamma-butyrobetaine dioxygenase activity | 0.0324182986052347 |
GO:0015811 | L-cystine transport | 0.0324182986052347 |
GO:0006082 | organic acid metabolic process | 0.0324182986052347 |
GO:0044248 | cellular catabolic process | 0.0346107058593573 |
GO:0022844 | voltage-gated anion channel activity | 0.034998389307259 |
GO:0030145 | manganese ion binding | 0.0377228017189514 |
GO:0009152 | purine ribonucleotide biosynthetic process | 0.0377228017189514 |
GO:0052185 | modification of structure of other organism during symbiotic interaction | 0.0377228017189514 |
GO:0051883 | killing of cells in other organism during symbiotic interaction | 0.0377228017189514 |
GO:0052331 | hemolysis by organism of red blood cells in other organism during symbiotic interaction | 0.0377228017189514 |
GO:0015879 | carnitine transport | 0.0377228017189514 |
GO:0031232 | extrinsic to external side of plasma membrane | 0.0377228017189514 |
GO:0008510 | sodium:bicarbonate symporter activity | 0.0377228017189514 |
GO:0019836 | hemolysis by symbiont of host red blood cells | 0.0377228017189514 |
GO:0015226 | carnitine transporter activity | 0.0377228017189514 |
GO:0051801 | cytolysis of cells in other organism during symbiotic interaction | 0.0377228017189514 |
GO:0001907 | killing by symbiont of host cells | 0.0377228017189514 |
GO:0031640 | killing of cells of another organism | 0.0377228017189514 |
GO:0001897 | cytolysis by symbiont of host cells | 0.0377228017189514 |
GO:0016244 | non-apoptotic programmed cell death | 0.0377228017189514 |
GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity | 0.0377228017189514 |
GO:0047961 | glycine N-acyltransferase activity | 0.0377228017189514 |
GO:0004053 | arginase activity | 0.0377228017189514 |
GO:0051818 | disruption of cells of other organism during symbiotic interaction | 0.0377228017189514 |
GO:0008453 | alanine-glyoxylate transaminase activity | 0.0377228017189514 |
GO:0015347 | sodium-independent organic anion transmembrane transporter activity | 0.0377228017189514 |
GO:0044004 | disruption by symbiont of host cells | 0.0377228017189514 |
GO:0051817 | modification of morphology or physiology of other organism during symbiotic interaction | 0.0377228017189514 |
GO:0051715 | cytolysis of cells of another organism | 0.0377228017189514 |
GO:0045329 | carnitine biosynthetic process | 0.0377228017189514 |
GO:0052332 | modification by organism of cell membrane in other organism during symbiotic interaction | 0.0377228017189514 |
GO:0043070 | regulation of non-apoptotic programmed cell death | 0.0377228017189514 |
GO:0052111 | modification by symbiont of host structure | 0.0377228017189514 |
GO:0052025 | modification by symbiont of host cell membrane | 0.0377228017189514 |
GO:0016174 | NAD(P)H oxidase activity | 0.0377228017189514 |
GO:0052043 | modification by symbiont of host cellular component | 0.0377228017189514 |
GO:0008422 | beta-glucosidase activity | 0.0377228017189514 |
GO:0044003 | modification by symbiont of host morphology or physiology | 0.0377228017189514 |
GO:0052188 | modification of cellular component in other organism during symbiotic interaction | 0.0377228017189514 |
GO:0009150 | purine ribonucleotide metabolic process | 0.0398921369785227 |
GO:0009260 | ribonucleotide biosynthetic process | 0.0398921369785227 |
GO:0006164 | purine nucleotide biosynthetic process | 0.0408152818066184 |
GO:0005249 | voltage-gated potassium channel activity | 0.0446167966825047 |
GO:0019825 | oxygen binding | 0.0449167010148656 |
GO:0009259 | ribonucleotide metabolic process | 0.0449167010148656 |
GO:0006163 | purine nucleotide metabolic process | 0.0449167010148656 |
GO:0006916 | anti-apoptosis | 0.0449167010148656 |
GO:0051354 | negative regulation of oxidoreductase activity | 0.0449167010148656 |
GO:0035085 | cilium axoneme | 0.0449167010148656 |
GO:0048567 | ectodermal gut morphogenesis | 0.0449167010148656 |
GO:0007439 | ectodermal gut development | 0.0449167010148656 |
GO:0015643 | toxin binding | 0.0449167010148656 |
GO:0015802 | basic amino acid transport | 0.0449167010148656 |
GO:0009437 | carnitine metabolic process | 0.0449167010148656 |
GO:0008410 | CoA-transferase activity | 0.0449167010148656 |
GO:0007442 | hindgut morphogenesis | 0.0449167010148656 |
GO:0051001 | negative regulation of nitric-oxide synthase activity | 0.0449167010148656 |
GO:0048523 | negative regulation of cellular process | 0.0449167010148656 |
GO:0031404 | chloride ion binding | 0.0463689246940225 |
GO:0043168 | anion binding | 0.0463689246940225 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
kidney | 3.90e-07 | 26 |
kidney mesenchyme | 3.90e-07 | 26 |
upper urinary tract | 3.90e-07 | 26 |
kidney rudiment | 3.90e-07 | 26 |
kidney field | 3.90e-07 | 26 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0 |
MA0004.1 | 0.00939958 |
MA0006.1 | 2.51533e-05 |
MA0007.1 | 0.0817144 |
MA0009.1 | 0.184542 |
MA0014.1 | 0 |
MA0017.1 | 3.89651 |
MA0019.1 | 0.0588715 |
MA0024.1 | 0.00258695 |
MA0025.1 | 0.425159 |
MA0027.1 | 0.921633 |
MA0028.1 | 3.0055e-08 |
MA0029.1 | 0.164092 |
MA0030.1 | 0.746949 |
MA0031.1 | 0.857676 |
MA0038.1 | 0.265003 |
MA0040.1 | 1.35148 |
MA0041.1 | 0.486171 |
MA0042.1 | 0.0907079 |
MA0043.1 | 0.316145 |
MA0046.1 | 45.1684 |
MA0048.1 | 0.0838171 |
MA0050.1 | 0.324729 |
MA0051.1 | 0.342532 |
MA0052.1 | 0.0443882 |
MA0055.1 | 0.0248564 |
MA0056.1 | 0 |
MA0057.1 | 0.000177652 |
MA0058.1 | 0.00161092 |
MA0059.1 | 0.00152834 |
MA0060.1 | 5.06293e-05 |
MA0061.1 | 0.0311181 |
MA0063.1 | 0 |
MA0066.1 | 0.752385 |
MA0067.1 | 0.0339468 |
MA0068.1 | 9.58418e-06 |
MA0069.1 | 1.80746 |
MA0070.1 | 1.09671 |
MA0071.1 | 1.126 |
MA0072.1 | 0.02759 |
MA0073.1 | 0 |
MA0074.1 | 0.175868 |
MA0076.1 | 8.87593e-05 |
MA0077.1 | 0.0656784 |
MA0078.1 | 0.274318 |
MA0081.1 | 0.175741 |
MA0083.1 | 0.0410404 |
MA0084.1 | 0.305436 |
MA0087.1 | 0.396772 |
MA0088.1 | 0.0109254 |
MA0089.1 | 0 |
MA0090.1 | 0.308671 |
MA0091.1 | 0.234574 |
MA0092.1 | 1.69554 |
MA0093.1 | 0.000910877 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0615713 |
MA0101.1 | 0.0847221 |
MA0103.1 | 0.340632 |
MA0105.1 | 0.000230058 |
MA0106.1 | 1.72988 |
MA0107.1 | 0.0194935 |
MA0108.2 | 0.643395 |
MA0109.1 | 0 |
MA0111.1 | 0.173759 |
MA0113.1 | 0.796291 |
MA0114.1 | 4.03837 |
MA0115.1 | 0.424437 |
MA0116.1 | 0.0151903 |
MA0117.1 | 0.0545249 |
MA0119.1 | 0.124617 |
MA0122.1 | 0.46398 |
MA0124.1 | 0.875183 |
MA0125.1 | 0.607112 |
MA0130.1 | 0 |
MA0131.1 | 1.29078e-05 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 5.64397 |
MA0136.1 | 0.288237 |
MA0139.1 | 0.000269639 |
MA0140.1 | 0.0652559 |
MA0141.1 | 2.48345 |
MA0142.1 | 0.693685 |
MA0143.1 | 1.187 |
MA0144.1 | 0.60809 |
MA0145.1 | 0.146036 |
MA0146.1 | 1.15049e-12 |
MA0147.1 | 1.80069e-05 |
MA0148.1 | 1.69867 |
MA0149.1 | 0.130661 |
MA0062.2 | 1.23934e-10 |
MA0035.2 | 0.101024 |
MA0039.2 | 0 |
MA0138.2 | 0.0376501 |
MA0002.2 | 1.30593 |
MA0137.2 | 0.938005 |
MA0104.2 | 2.45509e-07 |
MA0047.2 | 1.59821 |
MA0112.2 | 0.00617507 |
MA0065.2 | 1.31403 |
MA0150.1 | 1.20107 |
MA0151.1 | 0 |
MA0152.1 | 1.80403 |
MA0153.1 | 20.3341 |
MA0154.1 | 0.0393915 |
MA0155.1 | 0.00729441 |
MA0156.1 | 0.0505009 |
MA0157.1 | 1.40216 |
MA0158.1 | 0 |
MA0159.1 | 1.24722 |
MA0160.1 | 2.14781 |
MA0161.1 | 0 |
MA0162.1 | 0 |
MA0163.1 | 1.2083e-13 |
MA0164.1 | 0.301029 |
MA0080.2 | 0.0553913 |
MA0018.2 | 0.00628005 |
MA0099.2 | 0.236129 |
MA0079.2 | 0 |
MA0102.2 | 0.346878 |
MA0258.1 | 0.0461505 |
MA0259.1 | 7.8122e-05 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
BRF2#55290 | 3 | 9.2902788016889 | 0.00432525813985359 | 0.0205320501280928 |
FOXA2#3170 | 27 | 1.91649141591343 | 0.00109939167255868 | 0.00767868433694618 |
HNF4A#3172 | 29 | 1.93324616866184 | 0.000633057242425877 | 0.00519656255141996 |
HNF4G#3174 | 22 | 1.82298356075455 | 0.00553032833383727 | 0.0250371477245494 |
MAFF#23764 | 13 | 2.10979721720256 | 0.0100557912979472 | 0.0376597263013699 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data