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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.280667563736426

Latest revision as of 11:48, 17 September 2013


Full id: C1617_Fibroblast_meningioma_giant_Smooth_mesenchymal_hepatic_Olfactory



Phase1 CAGE Peaks

Hg19::chr11:122051194..122051210,-p5@ENST00000533109
Hg19::chr11:122051212..122051237,-p4@ENST00000533109
Hg19::chr11:122051243..122051257,-p3@ENST00000533109
Hg19::chr11:122051315..122051326,-p6@ENST00000533109
Hg19::chr11:122051327..122051348,-p2@ENST00000533109


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
multilaminar epithelium2.98e-2183
somite5.16e-2171
presomitic mesoderm5.16e-2171
presumptive segmental plate5.16e-2171
dermomyotome5.16e-2171
trunk paraxial mesoderm5.16e-2171
dense mesenchyme tissue2.09e-2073
paraxial mesoderm2.40e-2072
presumptive paraxial mesoderm2.40e-2072
epithelial vesicle3.81e-1878
skeletal muscle tissue1.60e-1762
striated muscle tissue1.60e-1762
myotome1.60e-1762
muscle tissue2.86e-1664
musculature2.86e-1664
musculature of body2.86e-1664
unilaminar epithelium1.48e-15148
surface structure1.79e-1499
vasculature1.25e-1278
vascular system1.25e-1278
organism subdivision2.13e-12264
cell layer3.45e-12309
artery8.29e-1242
arterial blood vessel8.29e-1242
arterial system8.29e-1242
epithelium1.97e-11306
trunk mesenchyme3.87e-11122
skin of body8.48e-1141
systemic artery5.40e-1033
systemic arterial system5.40e-1033
cardiovascular system5.94e-10109
integument6.34e-1046
integumental system6.34e-1046
splanchnic layer of lateral plate mesoderm7.56e-1083
mesenchyme1.06e-09160
entire embryonic mesenchyme1.06e-09160
circulatory system4.39e-09112
epithelial tube open at both ends6.24e-0959
blood vessel6.24e-0959
blood vasculature6.24e-0959
vascular cord6.24e-0959
vessel1.05e-0868
trunk6.71e-08199
subdivision of skeletal system1.60e-0716
head3.46e-0756
multi-tissue structure5.23e-07342
subdivision of head6.14e-0749
aorta8.80e-0721
aortic system8.80e-0721


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.554727
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.11.05325
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.11.2972
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.11.72991
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.23.17169
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.880827
MA0150.110.0123
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.11.3196
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.168633
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.24.06598
MA0079.20.146371
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105157.971147625824823.10621793420244e-050.000628215133288475
EP300#203356.77394172622327.00901578206049e-050.00110676534512037
FOS#235358.99795530889441.69470025615156e-050.000388568166964243
GATA2#2624512.7449317335542.9719152914525e-060.000101003534371626
NR3C1#2908514.9730233311731.32777388277837e-065.23683446161216e-05
STAT3#6774510.51946499715427.759040745861e-060.000220143019955712
TCF7L2#6934510.77017656313736.89693748574565e-060.00019947639270944



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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