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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.370976809908413

Latest revision as of 11:48, 17 September 2013


Full id: C1616_Fibroblast_Small_large_Smooth_liposarcoma_Myoblast_schwannoma



Phase1 CAGE Peaks

Hg19::chr11:122051099..122051122,-p1@ENST00000533109
Hg19::chr7:130596956..130596976,-p@chr7:130596956..130596976
-
Hg19::chr7:130596992..130597040,-p@chr7:130596992..130597040
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Hg19::chrX:45630639..45630663,-p@chrX:45630639..45630663
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Hg19::chrX:45630665..45630670,-p@chrX:45630665..45630670
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
multilaminar epithelium1.18e-1783
vasculature5.83e-1778
vascular system5.83e-1778
unilaminar epithelium1.10e-16148
somite1.16e-1671
presomitic mesoderm1.16e-1671
presumptive segmental plate1.16e-1671
dermomyotome1.16e-1671
trunk paraxial mesoderm1.16e-1671
epithelial vesicle1.99e-1678
dense mesenchyme tissue3.55e-1673
anatomical system4.07e-16624
paraxial mesoderm4.23e-1672
presumptive paraxial mesoderm4.23e-1672
anatomical group8.29e-16625
multi-cellular organism9.53e-16656
surface structure4.92e-1499
artery9.69e-1442
arterial blood vessel9.69e-1442
arterial system9.69e-1442
vessel9.81e-1468
skeletal muscle tissue1.65e-1362
striated muscle tissue1.65e-1362
myotome1.65e-1362
organism subdivision1.83e-13264
epithelial tube open at both ends2.75e-1359
blood vessel2.75e-1359
blood vasculature2.75e-1359
vascular cord2.75e-1359
muscle tissue7.55e-1364
musculature7.55e-1364
musculature of body7.55e-1364
cell layer2.40e-12309
epithelium9.66e-12306
trunk mesenchyme1.22e-11122
systemic artery2.54e-1133
systemic arterial system2.54e-1133
splanchnic layer of lateral plate mesoderm5.26e-1183
trunk7.95e-11199
skin of body3.13e-1041
epithelial tube9.92e-10117
integument1.04e-0946
integumental system1.04e-0946
cardiovascular system4.69e-09109
mesenchyme7.04e-09160
entire embryonic mesenchyme7.04e-09160
aorta1.27e-0821
aortic system1.27e-0821
circulatory system3.48e-08112
developing anatomical structure9.07e-08581
embryonic structure1.28e-07564
mesoderm1.38e-07315
mesoderm-derived structure1.38e-07315
presumptive mesoderm1.38e-07315
simple squamous epithelium3.13e-0722
germ layer3.35e-07560
germ layer / neural crest3.35e-07560
embryonic tissue3.35e-07560
presumptive structure3.35e-07560
germ layer / neural crest derived structure3.35e-07560
epiblast (generic)3.35e-07560
embryo6.30e-07592


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.12.45107
MA0073.10.0140295
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.11.36977
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.938075
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.30855
MA0137.21.20193
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.11.35623
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.10.480289
MA0157.12.04894
MA0158.10
MA0159.11.00463
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.24.06598
MA0079.20.000396307
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203356.77394172622327.00901578206049e-050.00110659803365475
FOS#235358.99795530889441.69470025615156e-050.000388482879833654
FOSL2#2355413.54416048364945.7953819349229e-050.000964410283463054
GATA2#262437.64695904013240.004279061879252130.0203284635920312
JUN#3725410.01026335386910.0001908531347801070.00230433647899417
JUND#372745.595731153496820.001849593301755460.0109295957249088
SMARCC1#6599217.46534372785260.005008037385199390.0233758398423615
STAT3#677436.311678998292540.007411172122460540.0306092223394494



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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