MCL coexpression mm9:53: Difference between revisions
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Latest revision as of 14:35, 17 September 2013
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0007423 | sensory organ development | 9.47654986616679e-07 |
GO:0046530 | photoreceptor cell differentiation | 9.47654986616679e-07 |
GO:0001654 | eye development | 3.26497410914507e-06 |
GO:0007601 | visual perception | 3.26497410914507e-06 |
GO:0050953 | sensory perception of light stimulus | 3.26497410914507e-06 |
GO:0001754 | eye photoreceptor cell differentiation | 1.10678440117758e-05 |
GO:0042461 | photoreceptor cell development | 1.23801671709141e-05 |
GO:0048856 | anatomical structure development | 2.52104981925866e-05 |
GO:0007399 | nervous system development | 6.54879175569097e-05 |
GO:0048731 | system development | 7.40857937582976e-05 |
GO:0007275 | multicellular organismal development | 0.000259376274293575 |
GO:0048592 | eye morphogenesis | 0.000354937556089943 |
GO:0042462 | eye photoreceptor cell development | 0.000389619127512225 |
GO:0045165 | cell fate commitment | 0.000424267990315689 |
GO:0030182 | neuron differentiation | 0.000518589445024273 |
GO:0000904 | cellular morphogenesis during differentiation | 0.000533046302310004 |
GO:0048699 | generation of neurons | 0.00101406563058271 |
GO:0048663 | neuron fate commitment | 0.00101406563058271 |
GO:0000902 | cell morphogenesis | 0.00128380490666511 |
GO:0032989 | cellular structure morphogenesis | 0.00128380490666511 |
GO:0022008 | neurogenesis | 0.00128380490666511 |
GO:0048468 | cell development | 0.00128380490666511 |
GO:0048513 | organ development | 0.00152786075503962 |
GO:0043010 | camera-type eye development | 0.00163647959389495 |
GO:0003677 | DNA binding | 0.00289419787113146 |
GO:0045449 | regulation of transcription | 0.00354737439227846 |
GO:0048869 | cellular developmental process | 0.00354737439227846 |
GO:0030154 | cell differentiation | 0.00354737439227846 |
GO:0050910 | detection of mechanical stimulus during sensory perception of sound | 0.00380131779332607 |
GO:0032502 | developmental process | 0.00393525272557421 |
GO:0043565 | sequence-specific DNA binding | 0.00393525272557421 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00401755776928268 |
GO:0006350 | transcription | 0.00480664060392488 |
GO:0009582 | detection of abiotic stimulus | 0.00510922351920809 |
GO:0009581 | detection of external stimulus | 0.00643095129863435 |
GO:0010468 | regulation of gene expression | 0.00741015284542047 |
GO:0050974 | detection of mechanical stimulus during sensory perception | 0.00748900152014095 |
GO:0018298 | protein-chromophore linkage | 0.00748900152014095 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.00748900152014095 |
GO:0009887 | organ morphogenesis | 0.00748900152014095 |
GO:0003676 | nucleic acid binding | 0.00748900152014095 |
GO:0007417 | central nervous system development | 0.00748900152014095 |
GO:0001764 | neuron migration | 0.00765330740335447 |
GO:0050906 | detection of stimulus during sensory perception | 0.00765330740335447 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.00770577128692022 |
GO:0006351 | transcription, DNA-dependent | 0.00775924259884845 |
GO:0032774 | RNA biosynthetic process | 0.00784159824812893 |
GO:0050982 | detection of mechanical stimulus | 0.00843926355248047 |
GO:0031323 | regulation of cellular metabolic process | 0.00997870906888017 |
GO:0001750 | photoreceptor outer segment | 0.0108672016843637 |
GO:0009653 | anatomical structure morphogenesis | 0.0116299560046059 |
GO:0051606 | detection of stimulus | 0.012522675779904 |
GO:0048839 | inner ear development | 0.012522675779904 |
GO:0005902 | microvillus | 0.012522675779904 |
GO:0031513 | nonmotile primary cilium | 0.012522675779904 |
GO:0009612 | response to mechanical stimulus | 0.012522675779904 |
GO:0045941 | positive regulation of transcription | 0.0133412526354085 |
GO:0050794 | regulation of cellular process | 0.0139210877220211 |
GO:0019222 | regulation of metabolic process | 0.0139210877220211 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0139210877220211 |
GO:0043583 | ear development | 0.0141951229000746 |
GO:0007411 | axon guidance | 0.0156180884435427 |
GO:0003700 | transcription factor activity | 0.0178220304677565 |
GO:0007420 | brain development | 0.0186601414133902 |
GO:0048523 | negative regulation of cellular process | 0.0192615543076 |
GO:0048489 | synaptic vesicle transport | 0.0195555378469325 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 0.0228567259848923 |
GO:0009952 | anterior/posterior pattern formation | 0.023438590037867 |
GO:0045664 | regulation of neuron differentiation | 0.0236534286986665 |
GO:0044464 | cell part | 0.0236534286986665 |
GO:0005623 | cell | 0.0236534286986665 |
GO:0065007 | biological regulation | 0.0236534286986665 |
GO:0030900 | forebrain development | 0.0236534286986665 |
GO:0021902 | commitment of a neuronal cell to a specific type of neuron in the forebrain | 0.0236534286986665 |
GO:0042706 | eye photoreceptor cell fate commitment | 0.0236534286986665 |
GO:0021877 | forebrain neuron fate commitment | 0.0236534286986665 |
GO:0051494 | negative regulation of cytoskeleton organization and biogenesis | 0.0236534286986665 |
GO:0046552 | photoreceptor cell fate commitment | 0.0236534286986665 |
GO:0005223 | intracellular cGMP activated cation channel activity | 0.0236534286986665 |
GO:0051639 | actin filament network formation | 0.0236534286986665 |
GO:0003905 | alkylbase DNA N-glycosylase activity | 0.0236534286986665 |
GO:0048519 | negative regulation of biological process | 0.0236534286986665 |
GO:0031325 | positive regulation of cellular metabolic process | 0.0236534286986665 |
GO:0016866 | intramolecular transferase activity | 0.0243945073041304 |
GO:0048666 | neuron development | 0.0259588344427676 |
GO:0042995 | cell projection | 0.0273380407185353 |
GO:0009893 | positive regulation of metabolic process | 0.0283128065220449 |
GO:0005834 | heterotrimeric G-protein complex | 0.0300677457212821 |
GO:0032501 | multicellular organismal process | 0.0313232354750019 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0313643933982341 |
GO:0008285 | negative regulation of cell proliferation | 0.0332766878262687 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0374920788039573 |
GO:0007015 | actin filament organization | 0.0374920788039573 |
GO:0019870 | potassium channel inhibitor activity | 0.0374920788039573 |
GO:0021526 | medial motor column neuron differentiation | 0.0374920788039573 |
GO:0009082 | branched chain family amino acid biosynthetic process | 0.0374920788039573 |
GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity | 0.0374920788039573 |
GO:0016080 | synaptic vesicle targeting | 0.0374920788039573 |
GO:0045872 | positive regulation of rhodopsin gene expression | 0.0374920788039573 |
GO:0050973 | detection of mechanical stimulus during equilibrioception | 0.0374920788039573 |
GO:0030046 | parallel actin filament bundle formation | 0.0374920788039573 |
GO:0004084 | branched-chain-amino-acid transaminase activity | 0.0374920788039573 |
GO:0015459 | potassium channel regulator activity | 0.0374920788039573 |
GO:0050789 | regulation of biological process | 0.0391773796645682 |
GO:0030902 | hindbrain development | 0.0404395852530488 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.0409120841740169 |
GO:0009953 | dorsal/ventral pattern formation | 0.0410531829228835 |
GO:0048858 | cell projection morphogenesis | 0.0410531829228835 |
GO:0032990 | cell part morphogenesis | 0.0410531829228835 |
GO:0030030 | cell projection organization and biogenesis | 0.0410531829228835 |
GO:0016070 | RNA metabolic process | 0.0423573150372536 |
GO:0016477 | cell migration | 0.043554932354085 |
GO:0003707 | steroid hormone receptor activity | 0.046649963027169 |
GO:0004879 | ligand-dependent nuclear receptor activity | 0.046649963027169 |
GO:0003002 | regionalization | 0.046649963027169 |
GO:0050957 | equilibrioception | 0.046649963027169 |
GO:0021523 | somatic motor neuron differentiation | 0.046649963027169 |
GO:0005221 | intracellular cyclic nucleotide activated cation channel activity | 0.046649963027169 |
GO:0035035 | histone acetyltransferase binding | 0.046649963027169 |
GO:0007468 | regulation of rhodopsin gene expression | 0.046649963027169 |
GO:0045749 | negative regulation of S phase of mitotic cell cycle | 0.046649963027169 |
GO:0043267 | negative regulation of potassium ion transport | 0.046649963027169 |
GO:0019789 | SUMO ligase activity | 0.046649963027169 |
GO:0043855 | cyclic nucleotide-gated ion channel activity | 0.046649963027169 |
GO:0019897 | extrinsic to plasma membrane | 0.0476480414634001 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
eye | 2.30e-78 | 9 |
camera-type eye | 2.30e-78 | 9 |
simple eye | 2.30e-78 | 9 |
immature eye | 2.30e-78 | 9 |
ocular region | 2.30e-78 | 9 |
visual system | 2.30e-78 | 9 |
face | 2.30e-78 | 9 |
optic cup | 2.30e-78 | 9 |
optic vesicle | 2.30e-78 | 9 |
eye primordium | 2.30e-78 | 9 |
subdivision of head | 4.15e-64 | 11 |
sense organ | 9.27e-59 | 12 |
sensory system | 9.27e-59 | 12 |
entire sense organ system | 9.27e-59 | 12 |
head | 3.12e-54 | 13 |
ectodermal placode | 3.12e-54 | 13 |
craniocervical region | 2.00e-19 | 36 |
anterior region of body | 3.35e-16 | 43 |
pre-chordal neural plate | 3.63e-14 | 49 |
neurectoderm | 9.81e-11 | 64 |
neural plate | 9.81e-11 | 64 |
presumptive neural plate | 9.81e-11 | 64 |
ecto-epithelium | 2.40e-09 | 73 |
structure with developmental contribution from neural crest | 2.71e-07 | 92 |
ectoderm-derived structure | 4.82e-07 | 95 |
ectoderm | 4.82e-07 | 95 |
presumptive ectoderm | 4.82e-07 | 95 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 4.92488e-09 |
MA0004.1 | 2.73421 |
MA0006.1 | 0.0382487 |
MA0007.1 | 0.0276986 |
MA0009.1 | 0.133894 |
MA0014.1 | 1.39528e-10 |
MA0017.1 | 0.152597 |
MA0019.1 | 0.271126 |
MA0024.1 | 0.0934332 |
MA0025.1 | 0.0263589 |
MA0027.1 | 1.00165 |
MA0028.1 | 0.000182174 |
MA0029.1 | 1.11802 |
MA0030.1 | 0.880399 |
MA0031.1 | 1.54348 |
MA0038.1 | 2.19478 |
MA0040.1 | 0.666348 |
MA0041.1 | 1.72803 |
MA0042.1 | 1.17137 |
MA0043.1 | 0.00852513 |
MA0046.1 | 1.35887 |
MA0048.1 | 0.0344471 |
MA0050.1 | 0.0127441 |
MA0051.1 | 0.0504146 |
MA0052.1 | 0.15607 |
MA0055.1 | 0.0222429 |
MA0056.1 | 0 |
MA0057.1 | 0.219272 |
MA0058.1 | 4.46774 |
MA0059.1 | 4.18594 |
MA0060.1 | 0.00213683 |
MA0061.1 | 0.327571 |
MA0063.1 | 0 |
MA0066.1 | 3.02408 |
MA0067.1 | 0.194737 |
MA0068.1 | 0.183229 |
MA0069.1 | 1.27761 |
MA0070.1 | 0.444073 |
MA0071.1 | 5.64111 |
MA0072.1 | 9.15312 |
MA0073.1 | 2.28554e-06 |
MA0074.1 | 0.00324229 |
MA0076.1 | 4.74676e-05 |
MA0077.1 | 2.5249 |
MA0078.1 | 1.75857 |
MA0081.1 | 0.371337 |
MA0083.1 | 0.122515 |
MA0084.1 | 2.42867 |
MA0087.1 | 1.1101 |
MA0088.1 | 0.00739779 |
MA0089.1 | 0 |
MA0090.1 | 0.0524376 |
MA0091.1 | 12.8795 |
MA0092.1 | 0.937985 |
MA0093.1 | 4.60458 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.101171 |
MA0101.1 | 0.484423 |
MA0103.1 | 0.248883 |
MA0105.1 | 0.00358394 |
MA0106.1 | 0.0870837 |
MA0107.1 | 0.443467 |
MA0108.2 | 0.658013 |
MA0109.1 | 0 |
MA0111.1 | 1.07172 |
MA0113.1 | 0.866026 |
MA0114.1 | 0.252185 |
MA0115.1 | 0.26004 |
MA0116.1 | 0.0563075 |
MA0117.1 | 0.0342393 |
MA0119.1 | 0.231833 |
MA0122.1 | 0.657127 |
MA0124.1 | 0.349294 |
MA0125.1 | 2.47186 |
MA0130.1 | 0 |
MA0131.1 | 0.0186491 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 5.87184 |
MA0136.1 | 0.00503415 |
MA0139.1 | 0.000543714 |
MA0140.1 | 0.325944 |
MA0141.1 | 0.0791752 |
MA0142.1 | 0.891331 |
MA0143.1 | 0.970123 |
MA0144.1 | 0.666653 |
MA0145.1 | 0.0368569 |
MA0146.1 | 1.88312e-05 |
MA0147.1 | 0.138843 |
MA0148.1 | 0.264562 |
MA0149.1 | 2.45202e-06 |
MA0062.2 | 2.48206e-09 |
MA0035.2 | 0.598197 |
MA0039.2 | 8.73328e-10 |
MA0138.2 | 0.0837648 |
MA0002.2 | 0.594661 |
MA0137.2 | 0.14777 |
MA0104.2 | 0.129458 |
MA0047.2 | 0.20967 |
MA0112.2 | 2.31272 |
MA0065.2 | 0.0761198 |
MA0150.1 | 0.790357 |
MA0151.1 | 0 |
MA0152.1 | 0.0436901 |
MA0153.1 | 0.0653808 |
MA0154.1 | 0.316983 |
MA0155.1 | 0.601358 |
MA0156.1 | 0.00801389 |
MA0157.1 | 0.541625 |
MA0158.1 | 0 |
MA0159.1 | 0.136709 |
MA0160.1 | 0.137012 |
MA0161.1 | 0 |
MA0162.1 | 1.47502e-09 |
MA0163.1 | 0.0592145 |
MA0164.1 | 1.37287 |
MA0080.2 | 0.000522195 |
MA0018.2 | 0.00620557 |
MA0099.2 | 0.00469675 |
MA0079.2 | 3.53185e-13 |
MA0102.2 | 0.230033 |
MA0258.1 | 1.00271 |
MA0259.1 | 0.0167827 |
MA0442.1 | 0 |