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{{UBERON
{{UBERON
|id=UBERON:0002242
|alt_id=UBERON:FMA_76703-MA_0000112
|name=nucleus pulposus
|namespace=
|def="a jelly-like connective tissue in the middle of the spinal disc. It is the remnant of the notochord. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of chondrocytes, collagen fibrils, and proteoglycan aggrecans that have hyaluronic long chains which attract water. Attached to each hyaluronic chain are side chains of chondroitin sulfate and keratan sulfate[WP]." [Wikipedia:Nucleus_pulposus]
|xref=BTO:0003626;;FMA:76703;;http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png;;http://upload.wikimedia.org/wikipedia/commons/thumb/d/d9/Cervical_vertebra_english.png/200px-Cervical_vertebra_english.png;;MA:0000112;;SCTID:316586000
|is_a=UBERON:0002384;;UBERON:0004120
|synonym="nucleus propulsus" RELATED [Wikipedia:Nucleus_pulposus];;"nucleus propulsus of intervertebral disk" RELATED [Wikipedia:Nucleus_pulposus];;"pulpy nucleus" EXACT []
|comment=
|comment=
|alt_id=UBERON:FMA_76703-MA_0000112
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="a jelly-like connective tissue in the middle of the spinal disc. It is the remnant of the notochord. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of chondrocytes, collagen fibrils, and proteoglycan aggrecans that have hyaluronic long chains which attract water. Attached to each hyaluronic chain are side chains of chondroitin sulfate and keratan sulfate[WP]." [Wikipedia:Nucleus_pulposus]
|subset=uberon_slim
|derives_from=
|derives_from=
|develops_from=
|develops_from=UBERON:0002328
|disjoint_from=
|has_quality=
|has_quality=
|id=UBERON:0002242
|is_a=UBERON:0002384 ;;UBERON:0004120 ;;UBERON:0004121
|is_obsolete=
|located_in=
|located_in=
|part_of=
|name=nucleus pulposus
|namespace=FANTOM
|obo_creation_date=
|part_of=UBERON:0001066
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|is_obsolete=
|subset=uberon_slim
|preceded_by=
|synonym="nucleus propulsus" RELATED [Wikipedia:Nucleus_pulposus];;"nucleus propulsus of intervertebral disk" RELATED [Wikipedia:Nucleus_pulposus];;"pulpy nucleus" EXACT []
|union_of=
|xref=BTO:0003626;;FMA:76703;;http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png;;http://upload.wikimedia.org/wikipedia/commons/thumb/d/d9/Cervical_vertebra_english.png/200px-Cervical_vertebra_english.png;;MA:0000112;;SCTID:316586000
}}
}}

Latest revision as of 17:28, 12 September 2014

Name:nucleus pulposus
Namespace:FANTOM
Definition:"a jelly-like connective tissue in the middle of the spinal disc. It is the remnant of the notochord. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of chondrocytes, collagen fibrils, and proteoglycan aggrecans that have hyaluronic long chains which attract water. Attached to each hyaluronic chain are side chains of chondroitin sulfate and keratan sulfate[WP]." [Wikipedia:Nucleus_pulposus]
Xrefs:
links:

BTO:0003626
FMA:76703
[ Cervical_vertebra_english.png Cervical_vertebra_english.png]
[ 200px-Cervical_vertebra_english.png 200px-Cervical_vertebra_english.png]
MA:0000112

SCTID:316586000
Synonyms: "nucleus propulsus" RELATED [Wikipedia:Nucleus_pulposus]
"nucleus propulsus of intervertebral disk" RELATED [Wikipedia:Nucleus_pulposus]
"pulpy nucleus" EXACT []
Alt_id: UBERON:FMA_76703-MA_0000112
Subset: uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0002384(connective tissue),UBERON:0004120(mesoderm-derived structure),UBERON:0004121(ectoderm-derived structure)
develops_from:UBERON:0002328(notochord)
part_of:UBERON:0001066(intervertebral disk)



Children

part of:CL:0002564 (nucleus pulposus cell of intervertebral disc)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002242 (nucleus pulposus), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
8.26e-98FFCP PHASE2:Hg19::chr3:174737010..174737023,+#_9908bbdfe64e7253070e2d1b5d5e68b3p@chr3:174737010..174737023, +
8.26e-98FFCP PHASE1:Hg19::chr3:174737010..174737023,+#_9908bbdfe64e7253070e2d1b5d5e68b3p@chr3:174737010..174737023, +
3.03e-84FFCP PHASE1:Hg19::chr20:21687193..21687206,+#_b283cc778965e26d8136ca1087fdb7f4p4@PAX1
3.03e-84FFCP PHASE2:Hg19::chr20:21687193..21687206,+#_b283cc778965e26d8136ca1087fdb7f4p4@PAX1
2.39e-66FFCP PHASE2:Hg19::chr9:33028063..33028067,-#_ac2a9f31d3fac17daa397a110618c700p@chr9:33028063..33028067, -
2.39e-66FFCP PHASE1:Hg19::chr9:33028063..33028067,-#_ac2a9f31d3fac17daa397a110618c700p@chr9:33028063..33028067, -
5.46e-60FFCP PHASE1:Hg19::chr5:30104176..30104187,-#_d91c248ea1fd2f92d4e0878a0077a876p@chr5:30104176..30104187, -
5.46e-60FFCP PHASE2:Hg19::chr5:30104176..30104187,-#_d91c248ea1fd2f92d4e0878a0077a876p@chr5:30104176..30104187, -
9.77e-45FFCP PHASE2:Hg19::chr2:241987807..241987808,+#_3e91449f47dd7e4ca724a9ad67ef7905p22@SNED1
9.77e-45FFCP PHASE1:Hg19::chr2:241987807..241987808,+#_3e91449f47dd7e4ca724a9ad67ef7905p22@SNED1
6.64e-41FFCP PHASE1:Hg19::chr2:242004292..242004308,+#_7797fd4f89d58dbd362680306fc43476p15@SNED1
6.64e-41FFCP PHASE2:Hg19::chr2:242004292..242004308,+#_7797fd4f89d58dbd362680306fc43476p15@SNED1
1.31e-40FFCP PHASE2:Hg19::chr1:19811132..19811155,-#_2da9a5a64067a5dd9721241acabaa677p20@CAPZB
1.31e-40FFCP PHASE1:Hg19::chr1:19811132..19811155,-#_2da9a5a64067a5dd9721241acabaa677p20@CAPZB
1.8e-38FFCP PHASE2:Hg19::chr2:12248310..12248334,-#_72a46cf7ab827fc3d3b9384f2b71f12cp@chr2:12248310..12248334, -
1.8e-38FFCP PHASE1:Hg19::chr2:12248310..12248334,-#_72a46cf7ab827fc3d3b9384f2b71f12cp@chr2:12248310..12248334, -
2.75e-34FFCP PHASE2:Hg19::chr14:61190754..61190776,-#_7b2da784d4d22535a4c7d0a064d50666p6@SIX4
2.75e-34FFCP PHASE1:Hg19::chr14:61190754..61190776,-#_7b2da784d4d22535a4c7d0a064d50666p6@SIX4
5.96e-34FFCP PHASE1:Hg19::chr11:93468399..93468405,-#_ffc341580f0556b63f2d4856a6993a1bp19@TAF1D, p1@SNORA40
5.96e-34FFCP PHASE2:Hg19::chr4:88727274..88727278,+#_ffc341580f0556b63f2d4856a6993a1bp@chr4:88727274..88727278, +
5.96e-34FFCP PHASE2:Hg19::chr11:93468399..93468405,-#_ffc341580f0556b63f2d4856a6993a1bp19@TAF1D, p1@SNORA40
5.96e-34FFCP PHASE1:Hg19::chr4:88727274..88727278,+#_ffc341580f0556b63f2d4856a6993a1bp@chr4:88727274..88727278, +
5.96e-34FFCP PHASE1:Hg19::chr13:51101468..51101499,-#_ffc341580f0556b63f2d4856a6993a1bp1@ENST00000428276
5.96e-34FFCP PHASE2:Hg19::chr13:51101468..51101499,-#_ffc341580f0556b63f2d4856a6993a1bp1@ENST00000428276
2.09e-33FFCP PHASE1:Hg19::chr4:13546130..13546145,-#_e3c5e1ff64b2fc3f184feeaf2e7f6dc0p4@NKX3-2
2.09e-33FFCP PHASE2:Hg19::chr4:13546130..13546145,-#_e3c5e1ff64b2fc3f184feeaf2e7f6dc0p4@NKX3-2
4.01e-31FFCP PHASE1:Hg19::chr7:18832913..18832946,+#_18adc13359a7fa12a7b74b392ddba0dfp19@HDAC9
4.01e-31FFCP PHASE2:Hg19::chr7:18832913..18832946,+#_18adc13359a7fa12a7b74b392ddba0dfp19@HDAC9
1.98e-30FFCP PHASE2:Hg19::chr2:241897125..241897142,-#_f29ba3fffd09d0e09c8dcab5d20e8a15p@chr2:241897125..241897142, -
1.98e-30FFCP PHASE1:Hg19::chr2:241897125..241897142,-#_f29ba3fffd09d0e09c8dcab5d20e8a15p@chr2:241897125..241897142, -
4.84e-30FFCP PHASE2:Hg19::chr3:80727046..80727051,-#_187d3fb745efe2e3457808cccbaacc9bp@chr3:80727046..80727051, -
4.84e-30FFCP PHASE1:Hg19::chr3:80727046..80727051,-#_187d3fb745efe2e3457808cccbaacc9bp@chr3:80727046..80727051, -
7.46e-30FFCP PHASE2:Hg19::chr7:158224707..158224729,-#_65160431060517f4c381e62645f15c2ap@chr7:158224707..158224729, -
7.46e-30FFCP PHASE1:Hg19::chr7:158224707..158224729,-#_65160431060517f4c381e62645f15c2ap@chr7:158224707..158224729, -
1.48e-29FFCP PHASE1:Hg19::chr1:65888177..65888194,+#_fba4f533158d57ab030828c7e33a3b39p@chr1:65888177..65888194, +
1.48e-29FFCP PHASE2:Hg19::chr1:65888177..65888194,+#_fba4f533158d57ab030828c7e33a3b39p@chr1:65888177..65888194, +
2.72e-28FFCP PHASE2:Hg19::chr14:100848311..100848321,+#_1122fcc8d470776b5c9ed6a92ae634c1p5@WDR25
2.72e-28FFCP PHASE1:Hg19::chr14:100848311..100848321,+#_1122fcc8d470776b5c9ed6a92ae634c1p5@WDR25
3.26e-27FFCP PHASE1:Hg19::chr1:78695274..78695292,+#_792c026113ad2fc316b6a9d9e2852f49p1@MGC27382
3.26e-27FFCP PHASE2:Hg19::chr1:78695274..78695292,+#_792c026113ad2fc316b6a9d9e2852f49p1@MGC27382
6.92e-27FFCP PHASE1:Hg19::chr1:19778678..19778689,-#_caea250b0330fe27d6e99dd0b7b1496ap@chr1:19778678..19778689, -
6.92e-27FFCP PHASE2:Hg19::chr1:19778678..19778689,-#_caea250b0330fe27d6e99dd0b7b1496ap@chr1:19778678..19778689, -
1.46e-26FFCP PHASE1:Hg19::chr7:18832834..18832859,+#_2f7a10ddee128986653a81509b65b4f7p18@HDAC9
1.46e-26FFCP PHASE2:Hg19::chr7:18832834..18832859,+#_2f7a10ddee128986653a81509b65b4f7p18@HDAC9
1.74e-26FFCP PHASE2:Hg19::chr4:156129991..156130013,+#_2a02f6ddec723a77d1a6dd4db996edbdp2@NPY2R
1.74e-26FFCP PHASE1:Hg19::chr4:156129991..156130013,+#_2a02f6ddec723a77d1a6dd4db996edbdp2@NPY2R
7.41e-26FFCP PHASE1:Hg19::chr14:61113228..61113233,-#_ac61b0901733d0b6614d238800371240p@chr14:61113228..61113233, -
7.41e-26FFCP PHASE2:Hg19::chr14:61113228..61113233,-#_ac61b0901733d0b6614d238800371240p@chr14:61113228..61113233, -
2.04e-25FFCP PHASE2:Hg19::chr7:27212374..27212387,-#_2c2b91e969124e891ea759ff54573f02p12@HOXA10
2.04e-25FFCP PHASE1:Hg19::chr7:27212374..27212387,-#_2c2b91e969124e891ea759ff54573f02p12@HOXA10
6.22e-25FFCP PHASE1:Hg19::chr14:23574186..23574212,-#_9ef9e90934a79b294365e47b86cd5fc5p1@uc010aki.1
6.22e-25FFCP PHASE2:Hg19::chr14:23574186..23574212,-#_9ef9e90934a79b294365e47b86cd5fc5p1@uc010aki.1
9.49e-25FFCP PHASE1:Hg19::chr20:21686317..21686350,+#_bd62e99ddc39b562f77e4aeb8f8c9316p1@PAX1
9.49e-25FFCP PHASE2:Hg19::chr20:21686317..21686350,+#_bd62e99ddc39b562f77e4aeb8f8c9316p1@PAX1
4.58e-24FFCP PHASE2:Hg19::chr5:140887761..140887777,+#_fadeaeb156a5711ecb39a7defce6aa53p@chr5:140887761..140887777, +
4.58e-24FFCP PHASE1:Hg19::chr5:140887761..140887777,+#_fadeaeb156a5711ecb39a7defce6aa53p@chr5:140887761..140887777, +
5.35e-24FFCP PHASE2:Hg19::chr20:21686290..21686311,+#_5a5e19ef742bf0ec9d400a58375c89e6p2@PAX1
5.35e-24FFCP PHASE1:Hg19::chr20:21686290..21686311,+#_5a5e19ef742bf0ec9d400a58375c89e6p2@PAX1
8.55e-24FFCP PHASE2:Hg19::chr7:18832759..18832786,+#_cf341a09d0858538bb5b2b98282fc131p16@HDAC9
8.55e-24FFCP PHASE1:Hg19::chr7:18832759..18832786,+#_cf341a09d0858538bb5b2b98282fc131p16@HDAC9
2.01e-23FFCP PHASE2:Hg19::chr4:77068930..77068959,-#_834bb0afe5216474def7cf1f9835dd9bp4@NUP54
2.01e-23FFCP PHASE1:Hg19::chr4:77068930..77068959,-#_834bb0afe5216474def7cf1f9835dd9bp4@NUP54
2.28e-23FFCP PHASE2:Hg19::chr4:13546632..13546662,-#_2be156d7dc30d8a4ea43a596aac46ae2p1@NKX3-2
2.28e-23FFCP PHASE1:Hg19::chr4:13546632..13546662,-#_2be156d7dc30d8a4ea43a596aac46ae2p1@NKX3-2
3.27e-23FFCP PHASE1:Hg19::chr14:23574164..23574179,-#_d4c24a1ceb2b02069e45a87331cef0a8p3@uc010aki.1
3.27e-23FFCP PHASE2:Hg19::chr14:23574164..23574179,-#_d4c24a1ceb2b02069e45a87331cef0a8p3@uc010aki.1
1.25e-22FFCP PHASE2:Hg19::chr1:78695343..78695353,+#_0da64b296480253cbcb6282783146047p2@ENST00000413519
1.25e-22FFCP PHASE1:Hg19::chr1:78695343..78695353,+#_0da64b296480253cbcb6282783146047p2@ENST00000413519
1.46e-22FFCP PHASE2:Hg19::chr9:123239747..123239765,-#_890f001f8a7346f0b44789f032ca6956p12@CDK5RAP2
1.46e-22FFCP PHASE1:Hg19::chr9:123239747..123239765,-#_890f001f8a7346f0b44789f032ca6956p12@CDK5RAP2
9.47e-22FFCP PHASE1:Hg19::chr1:171076859..171076870,+#_7c9cdf8ec6c429d4d3f2055965caf00cp@chr1:171076859..171076870, +
9.47e-22FFCP PHASE2:Hg19::chr1:171076859..171076870,+#_7c9cdf8ec6c429d4d3f2055965caf00cp@chr1:171076859..171076870, +
1.35e-21FFCP PHASE2:Hg19::chr7:100202784..100202796,-#_36d872a06c16c7f6c843ccb5fe0b7ff7p@chr7:100202784..100202796, -
1.35e-21FFCP PHASE1:Hg19::chr7:100202784..100202796,-#_36d872a06c16c7f6c843ccb5fe0b7ff7p@chr7:100202784..100202796, -
3.83e-21FFCP PHASE1:Hg19::chr14:37126814..37126834,+#_97e807756260f8e8cfd1378e48900c43p4@PAX9
3.83e-21FFCP PHASE2:Hg19::chr14:37126814..37126834,+#_97e807756260f8e8cfd1378e48900c43p4@PAX9
4.02e-21FFCP PHASE2:Hg19::chr3:176765178..176765190,-#_d52d5dbbda00e9deaab0a7532cfcf4a4p@chr3:176765178..176765190, -
4.02e-21FFCP PHASE1:Hg19::chr3:176765178..176765190,-#_d52d5dbbda00e9deaab0a7532cfcf4a4p@chr3:176765178..176765190, -
4.06e-21FFCP PHASE1:Hg19::chr1:19810947..19810977,-#_d0dbc3791eb4c579a7f03ae4e12cc084p17@CAPZB
4.06e-21FFCP PHASE2:Hg19::chr1:19810947..19810977,-#_d0dbc3791eb4c579a7f03ae4e12cc084p17@CAPZB
5.43e-21FFCP PHASE1:Hg19::chr12:54422268..54422278,+#_fb6380dae95693af4fb57a0b1b154848p8@HOXC6
5.43e-21FFCP PHASE2:Hg19::chr12:54422268..54422278,+#_fb6380dae95693af4fb57a0b1b154848p8@HOXC6
4.94e-20FFCP PHASE1:Hg19::chr17:38613285..38613298,-#_76cbc6f84a9552fed452dd88d516fd7bp@chr17:38613285..38613298, -
4.94e-20FFCP PHASE2:Hg19::chr17:38613285..38613298,-#_76cbc6f84a9552fed452dd88d516fd7bp@chr17:38613285..38613298, -
9.53e-20FFCP PHASE1:Hg19::chr20:43343596..43343608,+#_58e14cf665df29483074314583972d14p6@WISP2
9.53e-20FFCP PHASE2:Hg19::chr20:43343596..43343608,+#_58e14cf665df29483074314583972d14p6@WISP2
1.46e-19FFCP PHASE1:Hg19::chr1:78958320..78958332,+#_93b7654b8e3622ce084ba29ac7f03f94p2@PTGFR
1.46e-19FFCP PHASE2:Hg19::chr1:78958320..78958332,+#_93b7654b8e3622ce084ba29ac7f03f94p2@PTGFR
2.04e-19FFCP PHASE2:Hg19::chr4:70707689..70707711,-#_5381ebab2bcf4aafa2f6210999aee37ep@chr4:70707689..70707711, -
2.04e-19FFCP PHASE1:Hg19::chr4:70707689..70707711,-#_5381ebab2bcf4aafa2f6210999aee37ep@chr4:70707689..70707711, -
3.75e-19FFCP PHASE2:Hg19::chr14:37126870..37126882,+#_edba8f9b74c55b8d9bf141a19d41bb1dp1@ENST00000555639
3.75e-19FFCP PHASE1:Hg19::chr14:37126870..37126882,+#_edba8f9b74c55b8d9bf141a19d41bb1dp1@ENST00000555639
4.68e-19FFCP PHASE2:Hg19::chr2:12246664..12246694,+#_45d722775f0b480bebd6fe58e7f621b4p1@ENST00000449986
4.68e-19FFCP PHASE1:Hg19::chr2:12246664..12246694,+#_45d722775f0b480bebd6fe58e7f621b4p1@ENST00000449986
1.04e-18FFCP PHASE2:Hg19::chr3:158390171..158390180,-#_45a57f84ce1d41536372d71409ca0aa1p3@LXN
1.04e-18FFCP PHASE1:Hg19::chr3:158390171..158390180,-#_45a57f84ce1d41536372d71409ca0aa1p3@LXN
5.12e-18FFCP PHASE2:Hg19::chr6:112375300..112375334,+#_ac84cf8bc398581fe818fc0ade90faa3p1@WISP3
5.12e-18FFCP PHASE1:Hg19::chr6:112375300..112375334,+#_ac84cf8bc398581fe818fc0ade90faa3p1@WISP3
9.14e-18FFCP PHASE2:Hg19::chr8:77595678..77595688,+#_2cd97566b754dd832ab0278766c80382p9@ZFHX4
9.14e-18FFCP PHASE1:Hg19::chr8:77595678..77595688,+#_2cd97566b754dd832ab0278766c80382p9@ZFHX4

Retrieved from "http://f5-webapp4.gsc.riken.jp/resource_browser/index.php?title=UBERON:0002242&oldid=3277408"