UBERON:0001066

Name:	intervertebral disk
Namespace:	FANTOM
Definition:	"A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core." [ISBN10:0073040584, Wikipedia:Intervertebral_disk]
Xrefs:	Expandlinks: BTO:0003625 EFO:0001370 FMA:10446 GAID:105 [ 200px-Gray301.png] MA:0000110 MESH:A.02.165.410 ncithesaurus:Intervertebral_Disc OpenCyc:Mx4rv11AcpwpEbGdrcN5Y29ycA SCTID:244570000
Synonyms:	"discus intervertebralis" EXACT [FMA:10446, FMA:TA] "intervertebral disc" EXACT [] "intervertebral fibrocartilage" RELATED [BTO:0003625] "spinal disc" EXACT [Wikipedia:Spinal_disc] "spinal disk" RELATED [BTO:0003625]
Comments:	Taxon/Terminology notes: strictly speaking the term intervertebral disk [applies to intervertebral cartilage] whose gel-like core is nucleus puloposus, by this definition only in mammals
Alt_id:	UBERON:FMA_10446-MA_0000110
Subset:	uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

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Parents

is_a:	UBERON:0011135(intervertebral cartilage)

Children

part of:	UBERON:0002242 (nucleus pulposus),UBERON:0004715 (annulus fibrosus disci intervertebralis)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

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Human (Homo sapiens)

• 11248-116E6 (Anulus Pulposus Cell, donor1)
• 11252-116F1 (Nucleus Pulposus Cell, donor1)
• 11409-118E5 (Nucleus Pulposus Cell, donor2)
• 11462-119B4 (Nucleus Pulposus Cell, donor3)
• 11463-119B5 (Anulus Pulposus Cell, donor2)

Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001066 (intervertebral disk), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

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P-value	FFCP	Short description

P-value	FFCP	Short description
1.25e-162	FFCP PHASE2:Hg19::chr3:174737010..174737023,+	p@chr3:174737010..174737023, +
1.25e-162	FFCP PHASE1:Hg19::chr3:174737010..174737023,+	p@chr3:174737010..174737023, +
3.92e-140	FFCP PHASE1:Hg19::chr20:21687193..21687206,+	p4@PAX1
3.92e-140	FFCP PHASE2:Hg19::chr20:21687193..21687206,+	p4@PAX1
4.22e-99	FFCP PHASE2:Hg19::chr5:30104176..30104187,-	p@chr5:30104176..30104187, -
4.22e-99	FFCP PHASE1:Hg19::chr5:30104176..30104187,-	p@chr5:30104176..30104187, -
1.06e-78	FFCP PHASE2:Hg19::chr4:13546130..13546145,-	p4@NKX3-2
1.06e-78	FFCP PHASE1:Hg19::chr4:13546130..13546145,-	p4@NKX3-2
2.52e-71	FFCP PHASE1:Hg19::chr9:114135497..114135526,-	p@chr9:114135497..114135526, -
2.52e-71	FFCP PHASE2:Hg19::chr9:114135497..114135526,-	p@chr9:114135497..114135526, -
7.4e-71	FFCP PHASE1:Hg19::chr2:241897125..241897142,-	p@chr2:241897125..241897142, -
7.4e-71	FFCP PHASE2:Hg19::chr2:241897125..241897142,-	p@chr2:241897125..241897142, -
6.33e-70	FFCP PHASE1:Hg19::chr3:80727046..80727051,-	p@chr3:80727046..80727051, -
6.33e-70	FFCP PHASE2:Hg19::chr3:80727046..80727051,-	p@chr3:80727046..80727051, -
4.8e-67	FFCP PHASE1:Hg19::chr2:242004292..242004308,+	p15@SNED1
4.8e-67	FFCP PHASE2:Hg19::chr2:242004292..242004308,+	p15@SNED1
1.24e-66	FFCP PHASE2:Hg19::chr1:19811132..19811155,-	p20@CAPZB
1.24e-66	FFCP PHASE1:Hg19::chr1:19811132..19811155,-	p20@CAPZB
1.26e-62	FFCP PHASE1:Hg19::chr1:19778678..19778689,-	p@chr1:19778678..19778689, -
1.26e-62	FFCP PHASE2:Hg19::chr1:19778678..19778689,-	p@chr1:19778678..19778689, -
1.1e-59	FFCP PHASE1:Hg19::chr2:241897189..241897221,-	p@chr2:241897189..241897221, -
1.1e-59	FFCP PHASE2:Hg19::chr2:241897189..241897221,-	p@chr2:241897189..241897221, -
1.55e-57	FFCP PHASE1:Hg19::chr14:23574186..23574212,-	p1@uc010aki.1
1.55e-57	FFCP PHASE2:Hg19::chr14:23574186..23574212,-	p1@uc010aki.1
4.09e-56	FFCP PHASE1:Hg19::chr14:61190754..61190776,-	p6@SIX4
4.09e-56	FFCP PHASE2:Hg19::chr14:61190754..61190776,-	p6@SIX4
3.74e-53	FFCP PHASE1:Hg19::chr14:23574164..23574179,-	p3@uc010aki.1
3.74e-53	FFCP PHASE2:Hg19::chr14:23574164..23574179,-	p3@uc010aki.1
1.15e-51	FFCP PHASE2:Hg19::chr20:21687260..21687270,+	p3@PAX1
1.15e-51	FFCP PHASE1:Hg19::chr20:21687260..21687270,+	p3@PAX1
2.3e-51	FFCP PHASE2:Hg19::chr10:81923378..81923389,-	p@chr10:81923378..81923389, -
2.3e-51	FFCP PHASE1:Hg19::chr10:81923378..81923389,-	p@chr10:81923378..81923389, -
3.24e-51	FFCP PHASE2:Hg19::chr2:12248310..12248334,-	p@chr2:12248310..12248334, -
3.24e-51	FFCP PHASE1:Hg19::chr2:12248310..12248334,-	p@chr2:12248310..12248334, -
8.0e-51	FFCP PHASE1:Hg19::chr7:18832913..18832946,+	p19@HDAC9
8.0e-51	FFCP PHASE2:Hg19::chr7:18832913..18832946,+	p19@HDAC9
5.06e-49	FFCP PHASE1:Hg19::chr7:158224707..158224729,-	p@chr7:158224707..158224729, -
5.06e-49	FFCP PHASE2:Hg19::chr7:158224707..158224729,-	p@chr7:158224707..158224729, -
5.24e-48	FFCP PHASE1:Hg19::chr1:65888177..65888194,+	p@chr1:65888177..65888194, +
5.24e-48	FFCP PHASE2:Hg19::chr1:65888177..65888194,+	p@chr1:65888177..65888194, +
2.98e-45	FFCP PHASE2:Hg19::chr4:13546583..13546593,-	p3@NKX3-2
2.98e-45	FFCP PHASE1:Hg19::chr4:13546583..13546593,-	p3@NKX3-2
2.92e-44	FFCP PHASE1:Hg19::chr1:78695274..78695292,+	p1@MGC27382
2.92e-44	FFCP PHASE2:Hg19::chr1:78695274..78695292,+	p1@MGC27382
1.71e-43	FFCP PHASE1:Hg19::chr7:18832834..18832859,+	p18@HDAC9
1.71e-43	FFCP PHASE2:Hg19::chr7:18832834..18832859,+	p18@HDAC9
1.48e-40	FFCP PHASE1:Hg19::chr13:24914614..24914622,-	p@chr13:24914614..24914622, -
1.48e-40	FFCP PHASE2:Hg19::chr13:24914614..24914622,-	p@chr13:24914614..24914622, -
1.48e-40	FFCP PHASE2:Hg19::chr9:33028063..33028067,-	p@chr9:33028063..33028067, -
1.48e-40	FFCP PHASE1:Hg19::chr9:33028063..33028067,-	p@chr9:33028063..33028067, -
1.64e-40	FFCP PHASE1:Hg19::chr20:21686317..21686350,+	p1@PAX1
1.64e-40	FFCP PHASE2:Hg19::chr20:21686317..21686350,+	p1@PAX1
1.81e-40	FFCP PHASE1:Hg19::chr1:78769549..78769554,+	p5@PTGFR
1.81e-40	FFCP PHASE2:Hg19::chr1:78769549..78769554,+	p5@PTGFR
2.13e-40	FFCP PHASE1:Hg19::chr2:241897363..241897398,+	p@chr2:241897363..241897398, +
2.13e-40	FFCP PHASE2:Hg19::chr2:241897363..241897398,+	p@chr2:241897363..241897398, +
3.04e-39	FFCP PHASE1:Hg19::chr20:21686290..21686311,+	p2@PAX1
3.04e-39	FFCP PHASE2:Hg19::chr20:21686290..21686311,+	p2@PAX1
7.19e-39	FFCP PHASE2:Hg19::chr5:140887761..140887777,+	p@chr5:140887761..140887777, +
7.19e-39	FFCP PHASE1:Hg19::chr5:140887761..140887777,+	p@chr5:140887761..140887777, +
7.19e-39	FFCP PHASE1:Hg19::chr7:18832759..18832786,+	p16@HDAC9
7.19e-39	FFCP PHASE2:Hg19::chr7:18832759..18832786,+	p16@HDAC9
1.24e-38	FFCP PHASE1:Hg19::chr4:77068930..77068959,-	p4@NUP54
1.24e-38	FFCP PHASE2:Hg19::chr4:77068930..77068959,-	p4@NUP54
2.08e-38	FFCP PHASE2:Hg19::chr2:241938405..241938416,+	p@chr2:241938405..241938416, +
2.08e-38	FFCP PHASE1:Hg19::chr2:241938405..241938416,+	p@chr2:241938405..241938416, +
3.34e-38	FFCP PHASE2:Hg19::chr4:13546632..13546662,-	p1@NKX3-2
3.34e-38	FFCP PHASE1:Hg19::chr4:13546632..13546662,-	p1@NKX3-2
3.68e-38	FFCP PHASE1:Hg19::chr6:158490457..158490470,+	p10@SYNJ2
3.68e-38	FFCP PHASE2:Hg19::chr6:158490457..158490470,+	p10@SYNJ2
5.39e-38	FFCP PHASE2:Hg19::chr9:16138889..16138902,-	p@chr9:16138889..16138902, -
5.39e-38	FFCP PHASE1:Hg19::chr9:16138889..16138902,-	p@chr9:16138889..16138902, -
8.66e-38	FFCP PHASE2:Hg19::chr8:78311303..78311320,+	p2@ENST00000518706
8.66e-38	FFCP PHASE1:Hg19::chr8:78311303..78311320,+	p2@ENST00000518706
2.96e-37	FFCP PHASE2:Hg19::chr21:39705383..39705394,-	p1@ENST00000436845
2.96e-37	FFCP PHASE1:Hg19::chr21:39705383..39705394,-	p1@ENST00000436845
6.92e-37	FFCP PHASE2:Hg19::chr9:123239747..123239765,-	p12@CDK5RAP2
6.92e-37	FFCP PHASE1:Hg19::chr9:123239747..123239765,-	p12@CDK5RAP2
3.28e-36	FFCP PHASE1:Hg19::chr1:78695298..78695311,+	p1@ENST00000413519
3.28e-36	FFCP PHASE2:Hg19::chr1:78695298..78695311,+	p1@ENST00000413519
9.62e-35	FFCP PHASE1:Hg19::chr14:37126814..37126834,+	p4@PAX9
9.62e-35	FFCP PHASE2:Hg19::chr14:37126814..37126834,+	p4@PAX9
1.8e-34	FFCP PHASE1:Hg19::chr7:100202784..100202796,-	p@chr7:100202784..100202796, -
1.8e-34	FFCP PHASE2:Hg19::chr7:100202784..100202796,-	p@chr7:100202784..100202796, -
3.69e-34	FFCP PHASE2:Hg19::chr12:54422268..54422278,+	p8@HOXC6
3.69e-34	FFCP PHASE1:Hg19::chr12:54422268..54422278,+	p8@HOXC6
5.52e-34	FFCP PHASE2:Hg19::chr11:60610073..60610090,+	p6@CCDC86
5.52e-34	FFCP PHASE1:Hg19::chr11:60610073..60610090,+	p6@CCDC86
1.43e-33	FFCP PHASE1:Hg19::chr20:21695435..21695452,+	p@chr20:21695435..21695452, +
1.43e-33	FFCP PHASE2:Hg19::chr20:21695435..21695452,+	p@chr20:21695435..21695452, +
5.36e-33	FFCP PHASE1:Hg19::chr16:70795228..70795237,+	p@chr16:70795228..70795237, +
5.36e-33	FFCP PHASE2:Hg19::chr16:70795228..70795237,+	p@chr16:70795228..70795237, +
1.05e-32	FFCP PHASE1:Hg19::chr3:158384350..158384362,-	p@chr3:158384350..158384362, -
1.05e-32	FFCP PHASE2:Hg19::chr3:158384350..158384362,-	p@chr3:158384350..158384362, -
1.7e-32	FFCP PHASE2:Hg19::chr2:158345440..158345449,-	p9@CYTIP
1.7e-32	FFCP PHASE1:Hg19::chr2:158345440..158345449,-	p9@CYTIP
2.34e-32	FFCP PHASE2:Hg19::chr18:12012068..12012098,+	p@chr18:12012068..12012098, +
2.34e-32	FFCP PHASE1:Hg19::chr18:12012068..12012098,+	p@chr18:12012068..12012098, +
2.79e-31	FFCP PHASE1:Hg19::chr14:37126870..37126882,+	p1@ENST00000555639
2.79e-31	FFCP PHASE2:Hg19::chr14:37126870..37126882,+	p1@ENST00000555639

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