UBERON:0002067: Difference between revisions
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{{UBERON | {{UBERON | ||
| | |alt_id=UBERON:FMA_70323-MA_0000152-MIAA_0000153-XAO_0000217-ZFA_0001119 | ||
|comment=Editor notes: Consider adding a layer-of-skin grouping class for all skin layers | |comment=Editor notes: Consider adding a layer-of-skin grouping class for all skin layers | ||
|created_by= | |created_by= | ||
| | |def="The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [Wikipedia:Dermis, ZFIN:curator] | ||
|derives_from= | |derives_from= | ||
|develops_from= | |develops_from=UBERON:0004016;;UBERON:0010083 | ||
|disjoint_from= | |||
|has_quality= | |has_quality= | ||
|id=UBERON:0002067 | |||
|is_a=UBERON:0004120 ;;UBERON:0004121 ;;UBERON:0010314 ;;UBERON:0013754 | |||
|is_obsolete= | |||
|located_in= | |located_in= | ||
|part_of= | |name=dermis | ||
|namespace=FANTOM | |||
|obo_creation_date= | |||
|part_of=UBERON:0002097 | |||
|preceded_by= | |||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" xsd:string | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" xsd:string | ||
| | |subset=uberon_slim;;vertebrate_core | ||
| | |synonym="corium" RELATED [BTO:0000294];;"cutis" RELATED [BTO:0000294];;"dermis; corium" RELATED LATIN [Wikipedia:Dermis];;"vertebrate dermis" EXACT [] | ||
|union_of= | |||
|xref=AAO:0000128;;BTO:0000294;;EFO:0000953;;EV:0100154;;FMA:70323;;GAID:1321;;http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg;;MA:0000152;;MAT:0000153;;MESH:A.17.815.180;;MIAA:0000153;;ncithesaurus:Dermis;;SCTID:361696001;;TAO:0001119;;VHOG:0000108;;XAO:0000217;;ZFA:0001119 | |||
}} | }} |
Latest revision as of 17:25, 12 September 2014
Name: | dermis | ||
---|---|---|---|
Namespace: | FANTOM | ||
Definition: | "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [Wikipedia:Dermis, ZFIN:curator] | ||
Xrefs: |
| ||
Synonyms: |
"corium" RELATED [BTO:0000294] "cutis" RELATED [BTO:0000294] "dermis; corium" RELATED LATIN [Wikipedia:Dermis] "vertebrate dermis" EXACT [] | ||
Comments: | Editor notes: Consider adding a layer-of-skin grouping class for all skin layers | ||
Alt_id: | UBERON:FMA_70323-MA_0000152-MIAA_0000153-XAO_0000217-ZFA_0001119 | ||
Subset: |
uberon_slim vertebrate_core |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
is_a: | UBERON:0004120(mesoderm-derived structure),UBERON:0004121(ectoderm-derived structure),UBERON:0010314(structure with developmental contribution from neural crest),UBERON:0013754(integumentary system layer) |
---|---|
develops_from: | UBERON:0004016(dermatome),UBERON:0010083(future dermis) |
part_of: | UBERON:0002097(skin of body) |
Children
develops from: | UBERON:0004756 (dermal skeletal element) |
---|---|
part of: | UBERON:0001992 (papillary layer of dermis),CL:0002551 (fibroblast of dermis) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Human (Homo sapiens)
- 11269-116G9 (Fibroblast - Dermal, donor1)
- 11271-116H2 (Hair Follicle Dermal Papilla Cells, donor1)
- 11346-117G5 (Fibroblast - Dermal, donor2)
- 11348-117G7 (Hair Follicle Dermal Papilla Cells, donor2)
- 11418-118F5 (Fibroblast - Dermal, donor3)
- 11420-118F7 (Hair Follicle Dermal Papilla Cells, donor3)
- 11450-119A1 (Fibroblast - Dermal, donor4)
- 11454-119A5 (Fibroblast - Dermal, donor5)
- 11458-119A9 (Fibroblast - Dermal, donor6)
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002067 (dermis), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
P-value | FFCP | Short description |
---|---|---|
1.31e-68 | FFCP PHASE2:Hg19::chr1:45087872..45087892,+#_73a5fe415b7ca65484bdfc742826348d | p@chr1:45087872..45087892, + |
1.31e-68 | FFCP PHASE1:Hg19::chr1:45087872..45087892,+#_73a5fe415b7ca65484bdfc742826348d | p@chr1:45087872..45087892, + |
9.25e-50 | FFCP PHASE1:Hg19::chr7:107707064..107707079,-#_83d7fbf3a7befa7de290a45886be4910 | p@chr7:107707064..107707079, - |
9.25e-50 | FFCP PHASE2:Hg19::chr7:107707064..107707079,-#_83d7fbf3a7befa7de290a45886be4910 | p@chr7:107707064..107707079, - |
9.25e-50 | FFCP PHASE1:Hg19::chr7:107707083..107707099,-#_83d7fbf3a7befa7de290a45886be4910 | p@chr7:107707083..107707099, - |
9.25e-50 | FFCP PHASE2:Hg19::chr7:107707083..107707099,-#_83d7fbf3a7befa7de290a45886be4910 | p@chr7:107707083..107707099, - |
9.89e-40 | FFCP PHASE2:Hg19::chr10:124254447..124254458,-#_70b5dd352ade128910bdd82040833306 | p@chr10:124254447..124254458, - |
9.89e-40 | FFCP PHASE1:Hg19::chr10:124254447..124254458,-#_70b5dd352ade128910bdd82040833306 | p@chr10:124254447..124254458, - |
1.21e-39 | FFCP PHASE1:Hg19::chr1:10228206..10228218,+#_474993e40a080f515fefa529e8cce632 | p@chr1:10228206..10228218, + |
1.21e-39 | FFCP PHASE2:Hg19::chr1:10228206..10228218,+#_474993e40a080f515fefa529e8cce632 | p@chr1:10228206..10228218, + |
5.08e-38 | FFCP PHASE2:Hg19::chr6:5498703..5498727,+#_3f9a54ca105947556fa5031d3b942884 | p@chr6:5498703..5498727, + |
5.08e-38 | FFCP PHASE1:Hg19::chr6:5498703..5498727,+#_3f9a54ca105947556fa5031d3b942884 | p@chr6:5498703..5498727, + |
2.83e-35 | FFCP PHASE2:Hg19::chr8:128387795..128387801,+#_86141da7369306346e1d7fcfad6e08f6 | p@chr8:128387795..128387801, + |
2.83e-35 | FFCP PHASE1:Hg19::chr8:128387795..128387801,+#_86141da7369306346e1d7fcfad6e08f6 | p@chr8:128387795..128387801, + |
1.55e-33 | FFCP PHASE2:Hg19::chr1:45088343..45088354,+#_7bd56040ab10bf8a0e52e3ed8f20d8ca | p@chr1:45088343..45088354, + |
1.55e-33 | FFCP PHASE1:Hg19::chr1:45088343..45088354,+#_7bd56040ab10bf8a0e52e3ed8f20d8ca | p@chr1:45088343..45088354, + |
5.64e-29 | FFCP PHASE2:Hg19::chr7:98258032..98258045,+#_610f64bf5c24b08515d2c07ef60c9fe5 | p@chr7:98258032..98258045, + |
5.64e-29 | FFCP PHASE1:Hg19::chr7:98258032..98258045,+#_610f64bf5c24b08515d2c07ef60c9fe5 | p@chr7:98258032..98258045, + |
7.57e-28 | FFCP PHASE2:Hg19::chr10:31071229..31071236,+#_046bda63a381043f46a7064c56d8bb9b | p@chr10:31071229..31071236, + |
7.57e-28 | FFCP PHASE1:Hg19::chr10:31071229..31071236,+#_046bda63a381043f46a7064c56d8bb9b | p@chr10:31071229..31071236, + |
1.12e-26 | FFCP PHASE1:Hg19::chr5:33794920..33794939,-#_9a62e126fea2d1795cb0c0c25f092ca9 | p@chr5:33794920..33794939, - |
1.12e-26 | FFCP PHASE2:Hg19::chr5:33794920..33794939,-#_9a62e126fea2d1795cb0c0c25f092ca9 | p@chr5:33794920..33794939, - |
1.47e-26 | FFCP PHASE2:Hg19::chr21:47405899..47405911,+#_497ee5b4c828ab5bbf65f00766dc5c2e | p@chr21:47405899..47405911, + |
1.47e-26 | FFCP PHASE1:Hg19::chr21:47405899..47405911,+#_497ee5b4c828ab5bbf65f00766dc5c2e | p@chr21:47405899..47405911, + |
1.5e-25 | FFCP PHASE1:Hg19::chr17:38174999..38175001,+#_ff89e28a3d6aea3b34c0121975f4f106 | p8@CASC3 |
1.5e-25 | FFCP PHASE2:Hg19::chr4:89454373..89454379,-#_ff89e28a3d6aea3b34c0121975f4f106 | p@chr4:89454373..89454379, - |
1.5e-25 | FFCP PHASE2:Hg19::chr17:38174999..38175001,+#_ff89e28a3d6aea3b34c0121975f4f106 | p8@CASC3 |
1.5e-25 | FFCP PHASE1:Hg19::chr4:89454373..89454379,-#_ff89e28a3d6aea3b34c0121975f4f106 | p@chr4:89454373..89454379, - |
2.99e-25 | FFCP PHASE2:Hg19::chr8:141656896..141656918,-#_8aaa078761cdfb0bca575125dab819fc | p@chr8:141656896..141656918, - |
2.99e-25 | FFCP PHASE1:Hg19::chr8:141656896..141656918,-#_8aaa078761cdfb0bca575125dab819fc | p@chr8:141656896..141656918, - |
3.17e-25 | FFCP PHASE1:Hg19::chr2:95983133..95983144,+#_734ddac16dfeb01d14d15eef209df0c1 | p@chr2:95983133..95983144, + |
3.17e-25 | FFCP PHASE2:Hg19::chr2:95983133..95983144,+#_734ddac16dfeb01d14d15eef209df0c1 | p@chr2:95983133..95983144, + |
2.03e-24 | FFCP PHASE1:Hg19::chr5:33794876..33794902,-#_a3e8e64e44620fb712c82f98eb4fbb82 | p@chr5:33794876..33794902, - |
2.03e-24 | FFCP PHASE2:Hg19::chr5:33794876..33794902,-#_a3e8e64e44620fb712c82f98eb4fbb82 | p@chr5:33794876..33794902, - |
2.4e-24 | FFCP PHASE2:Hg19::chr5:174252830..174252847,+#_3961e80021c6c4ac3b3475561ae8c38f | p@chr5:174252830..174252847, + |
2.4e-24 | FFCP PHASE1:Hg19::chr5:174252830..174252847,+#_3961e80021c6c4ac3b3475561ae8c38f | p@chr5:174252830..174252847, + |
2.92e-24 | FFCP PHASE2:Hg19::chr4:127699583..127699608,-#_b1213e2ceb0b12210879ddf8bef5caeb | p@chr4:127699583..127699608, - |
2.92e-24 | FFCP PHASE1:Hg19::chr4:127699583..127699608,-#_b1213e2ceb0b12210879ddf8bef5caeb | p@chr4:127699583..127699608, - |
1.68e-23 | FFCP PHASE2:Hg19::chr4:127876558..127876592,-#_bc534413383b7379f99a99a8fb3c328c | p1@ENST00000515428 |
1.68e-23 | FFCP PHASE1:Hg19::chr4:127876558..127876592,-#_bc534413383b7379f99a99a8fb3c328c | p1@ENST00000515428 |
2.62e-23 | FFCP PHASE1:Hg19::chr7:127963997..127964004,-#_99be5715d44e1f0d829194fbc837a0ba | p@chr7:127963997..127964004, - |
2.62e-23 | FFCP PHASE2:Hg19::chr7:127963997..127964004,-#_99be5715d44e1f0d829194fbc837a0ba | p@chr7:127963997..127964004, - |
3.32e-23 | FFCP PHASE1:Hg19::chr17:813116..813132,+#_9c331ac2c2def4dfc4c6cd03e66e2d49 | p@chr17:813116..813132, + |
3.32e-23 | FFCP PHASE2:Hg19::chr17:813116..813132,+#_9c331ac2c2def4dfc4c6cd03e66e2d49 | p@chr17:813116..813132, + |
6.41e-23 | FFCP PHASE2:Hg19::chr16:85617034..85617043,-#_bcb629a8b3ff824d199c6666b8dd49b2 | p@chr16:85617034..85617043, - |
6.41e-23 | FFCP PHASE1:Hg19::chr16:85617034..85617043,-#_bcb629a8b3ff824d199c6666b8dd49b2 | p@chr16:85617034..85617043, - |
7.17e-23 | FFCP PHASE1:Hg19::chr5:177652352..177652356,-#_e619161e9360c085006bd0eeb42eb676 | p6@AGXT2L2 |
7.17e-23 | FFCP PHASE2:Hg19::chr5:177652352..177652356,-#_e619161e9360c085006bd0eeb42eb676 | p6@AGXT2L2 |
7.17e-23 | FFCP PHASE2:Hg19::chr5:174252850..174252859,+#_e619161e9360c085006bd0eeb42eb676 | p@chr5:174252850..174252859, + |
7.17e-23 | FFCP PHASE1:Hg19::chr5:174252850..174252859,+#_e619161e9360c085006bd0eeb42eb676 | p@chr5:174252850..174252859, + |
4.19e-22 | FFCP PHASE1:Hg19::chr5:33794904..33794916,-#_ed598c139a2131b8b73c398609bec48d | p@chr5:33794904..33794916, - |
4.19e-22 | FFCP PHASE2:Hg19::chr5:33794904..33794916,-#_ed598c139a2131b8b73c398609bec48d | p@chr5:33794904..33794916, - |
3.14e-21 | FFCP PHASE2:Hg19::chr11:122051600..122051617,+#_6f54d0e495c3bbd898fc5fd9f46b4d80 | p@chr11:122051600..122051617, + |
3.14e-21 | FFCP PHASE1:Hg19::chr11:122051600..122051617,+#_6f54d0e495c3bbd898fc5fd9f46b4d80 | p@chr11:122051600..122051617, + |
7.71e-21 | FFCP PHASE2:Hg19::chr21:36208749..36208768,+#_9d79ad6f447872beae5f10b3e1476678 | p@chr21:36208749..36208768, + |
7.71e-21 | FFCP PHASE1:Hg19::chr21:36208749..36208768,+#_9d79ad6f447872beae5f10b3e1476678 | p@chr21:36208749..36208768, + |
8.88e-21 | FFCP PHASE2:Hg19::chr20:940152..940156,-#_7506eb14b15990149eb496937df87027 | p@chr20:940152..940156, - |
8.88e-21 | FFCP PHASE1:Hg19::chr20:940152..940156,-#_7506eb14b15990149eb496937df87027 | p@chr20:940152..940156, - |
9.8e-21 | FFCP PHASE2:Hg19::chr18:52969844..52969895,-#_143c9f5631ccfa4b71c160c60c8c347a | p27@TCF4 |
9.8e-21 | FFCP PHASE1:Hg19::chr18:52969844..52969895,-#_143c9f5631ccfa4b71c160c60c8c347a | p27@TCF4 |
1.24e-20 | FFCP PHASE2:Hg19::chr1:45087902..45087912,+#_5a2d99923a3746795931e29a05da8b64 | p@chr1:45087902..45087912, + |
1.24e-20 | FFCP PHASE1:Hg19::chr1:45087902..45087912,+#_5a2d99923a3746795931e29a05da8b64 | p@chr1:45087902..45087912, + |
1.29e-20 | FFCP PHASE1:Hg19::chr12:66036219..66036262,-#_42d2c65fd910d903d7eecfdfb1d6f5c2 | p1@ENST00000544557 |
1.29e-20 | FFCP PHASE2:Hg19::chr12:66036219..66036262,-#_42d2c65fd910d903d7eecfdfb1d6f5c2 | p1@ENST00000544557 |
1.32e-20 | FFCP PHASE2:Hg19::chr7:152549181..152549213,+#_c9d0ab832f95fcd100382eb68c9b3f3f | p@chr7:152549181..152549213, + |
1.32e-20 | FFCP PHASE1:Hg19::chr7:152549181..152549213,+#_c9d0ab832f95fcd100382eb68c9b3f3f | p@chr7:152549181..152549213, + |
1.73e-20 | FFCP PHASE1:Hg19::chr1:119530682..119530692,-#_c5ba0e7673122a5781d0b306c4b1a29c | p10@TBX15 |
1.73e-20 | FFCP PHASE2:Hg19::chr1:119530682..119530692,-#_c5ba0e7673122a5781d0b306c4b1a29c | p10@TBX15 |
2.11e-20 | FFCP PHASE2:Hg19::chr17:73682761..73682766,+#_76845917640f73793a5284815887a905 | p@chr17:73682761..73682766, + |
2.11e-20 | FFCP PHASE1:Hg19::chr17:73682761..73682766,+#_76845917640f73793a5284815887a905 | p@chr17:73682761..73682766, + |
4.35e-19 | FFCP PHASE1:Hg19::chr14:38371323..38371347,-#_c28d560026fc89e3a7f451ebbc0a1ca6 | p1@ENST00000554257, p1@uc001wuk.1 |
4.35e-19 | FFCP PHASE2:Hg19::chr14:38371323..38371347,-#_c28d560026fc89e3a7f451ebbc0a1ca6 | p1@ENST00000554257, p1@uc001wuk.1 |
4.67e-19 | FFCP PHASE2:Hg19::chr21:47404148..47404163,+#_067d3581df4479a43f054699b98c6079 | p@chr21:47404148..47404163, + |
4.67e-19 | FFCP PHASE1:Hg19::chr21:47404148..47404163,+#_067d3581df4479a43f054699b98c6079 | p@chr21:47404148..47404163, + |
5.29e-19 | FFCP PHASE2:Hg19::chr4:5754385..5754405,+#_28b5033bd52d339a14409772175ff83a | p3@EVC |
5.29e-19 | FFCP PHASE1:Hg19::chr4:5754385..5754405,+#_28b5033bd52d339a14409772175ff83a | p3@EVC |
1.22e-18 | FFCP PHASE1:Hg19::chr2:177022022..177022060,+#_06fc5fd1fc973e779bd0bccfa3523cf6 | p@chr2:177022022..177022060, + |
1.22e-18 | FFCP PHASE2:Hg19::chr2:177022022..177022060,+#_06fc5fd1fc973e779bd0bccfa3523cf6 | p@chr2:177022022..177022060, + |
1.35e-18 | FFCP PHASE2:Hg19::chr12:2163623..2163634,+#_02b5c23bbd882832a4773914bb5deb2e | p@chr12:2163623..2163634, + |
1.35e-18 | FFCP PHASE1:Hg19::chr12:5198401..5198415,+#_02b5c23bbd882832a4773914bb5deb2e | p@chr12:5198401..5198415, + |
1.35e-18 | FFCP PHASE2:Hg19::chr12:5198401..5198415,+#_02b5c23bbd882832a4773914bb5deb2e | p@chr12:5198401..5198415, + |
1.35e-18 | FFCP PHASE1:Hg19::chr12:2163623..2163634,+#_02b5c23bbd882832a4773914bb5deb2e | p@chr12:2163623..2163634, + |
1.51e-17 | FFCP PHASE1:Hg19::chr2:201474023..201474035,+#_21c1055b7d754aeb90af6a110e2dcfb0 | p5@AOX1 |
1.51e-17 | FFCP PHASE2:Hg19::chr2:201474023..201474035,+#_21c1055b7d754aeb90af6a110e2dcfb0 | p5@AOX1 |
3.53e-17 | FFCP PHASE1:Hg19::chr12:66036083..66036098,-#_3bfc1a4bf3509f0c05cc4d3fb614314c | p3@ENST00000539653 |
3.53e-17 | FFCP PHASE2:Hg19::chr12:66036083..66036098,-#_3bfc1a4bf3509f0c05cc4d3fb614314c | p3@ENST00000539653 |
4.17e-17 | FFCP PHASE2:Hg19::chrX:118362928..118362933,+#_c9daf3dffe3124a44434e27e33199ef8 | p@chrX:118362928..118362933, + |
4.17e-17 | FFCP PHASE1:Hg19::chrX:118362928..118362933,+#_c9daf3dffe3124a44434e27e33199ef8 | p@chrX:118362928..118362933, + |
4.92e-17 | FFCP PHASE2:Hg19::chr4:81159520..81159523,+#_02b625b5f69b0559649f7fc0c2df37c4 | p@chr4:81159520..81159523, + |
4.92e-17 | FFCP PHASE1:Hg19::chr4:81159520..81159523,+#_02b625b5f69b0559649f7fc0c2df37c4 | p@chr4:81159520..81159523, + |
7.89e-17 | FFCP PHASE1:Hg19::chr2:177502906..177502920,-#_d3c4197e4f45cbb8c05259525af8057b | p2@ENST00000295549, p2@uc002ukz.1 |
7.89e-17 | FFCP PHASE2:Hg19::chr2:177502906..177502920,-#_d3c4197e4f45cbb8c05259525af8057b | p2@ENST00000295549, p2@uc002ukz.1 |
8.61e-17 | FFCP PHASE1:Hg19::chr1:85987126..85987173,-#_3fae0e5e2bb1461ffb9b9a6907faa3fd | p@chr1:85987126..85987173, - |
8.61e-17 | FFCP PHASE2:Hg19::chr1:85987126..85987173,-#_3fae0e5e2bb1461ffb9b9a6907faa3fd | p@chr1:85987126..85987173, - |
8.66e-17 | FFCP PHASE2:Hg19::chr3:139000423..139000454,+#_aad0518a5dabf6662a30d4cdf2f9ccac | p3@MRPS22 |
8.66e-17 | FFCP PHASE1:Hg19::chr3:139000423..139000454,+#_aad0518a5dabf6662a30d4cdf2f9ccac | p3@MRPS22 |
9.03e-17 | FFCP PHASE2:Hg19::chr17:46627545..46627560,+#_4965deb446ec377d8d65e14c10795d43 | p@chr17:46627545..46627560, + |
9.03e-17 | FFCP PHASE1:Hg19::chr17:46627545..46627560,+#_4965deb446ec377d8d65e14c10795d43 | p@chr17:46627545..46627560, + |
1.05e-16 | FFCP PHASE2:Hg19::chr20:4451008..4451026,-#_8bc478fb7fa770443d3be8933d96ec52 | p@chr20:4451008..4451026, - |
1.05e-16 | FFCP PHASE1:Hg19::chr20:4451008..4451026,-#_8bc478fb7fa770443d3be8933d96ec52 | p@chr20:4451008..4451026, - |
Property "Property value" (as page type) with input value "UBPROP:0000001 "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.