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{{Coexpression_clusters
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|full_id=C4761_testicular_Wilms_mucinous_lung_large_H9_mesothelioma
|id=C4761
|ontology_enrichment_celltype=CL:0000548!8.77e-23!679;CL:0000004!8.77e-23!679;CL:0000255!8.77e-23!679;CL:0000012!5.47e-22!682;CL:0000063!1.01e-13!578;CL:0000003!1.04e-13!722;CL:0000066!3.56e-10!254;CL:0000144!3.56e-08!625
|ontology_enrichment_disease=DOID:14566!1.17e-41!239;DOID:162!1.74e-41!235;DOID:0050687!1.82e-25!143;DOID:305!1.16e-19!106;DOID:0050686!1.91e-19!137;DOID:7!2.56e-08!39
|ontology_enrichment_uberon=UBERON:0004458!5.89e-08!49;UBERON:0002323!1.38e-07!46
}}

Latest revision as of 14:19, 17 September 2013


Full id: C4761_testicular_Wilms_mucinous_lung_large_H9_mesothelioma



Phase1 CAGE Peaks

Hg19::chr8:54934889..54934901,-p5@TCEA1
Hg19::chr8:54934917..54934938,-p3@TCEA1
Hg19::chr8:54934978..54935000,-p2@TCEA1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
animal cell5.63e-21679
eukaryotic cell5.63e-21679
native cell8.53e-13722
epithelial cell1.87e-10253
endodermal cell4.83e-0758
Uber Anatomy
Ontology termp-valuen
body cavity or lining2.46e-0849
body cavity7.71e-0846
Disease
Ontology termp-valuen
disease of cellular proliferation2.67e-42239
cancer1.33e-41235
cell type cancer4.69e-25143
organ system cancer1.11e-19137
carcinoma2.60e-19106
disease of anatomical entity1.50e-0839


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.12.26702
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.12.01615
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.14.21544
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.13.52399
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.69213
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0191323858407629
CEBPB#105137.971147625824820.001974187055288560.0115858688394741
E2F1#186934.907389214879320.008460985347239390.0327960528756062
E2F4#1874312.66806031528440.0004917987006298980.00439224940098221
E2F6#187635.017155731697390.00791769806886330.0324586461223902
EBF1#187938.9064668465690.00141523283560980.00919474352213078
EGR1#195834.988179094810140.008056488137383440.0322713751612852
ELF1#199734.258097958807540.01295179875054610.0465203738249573
EP300#203336.77394172622320.003216880500103790.0168590818220765
ETS1#211339.728760922202340.001085840092584840.00765777928485838
GABPB1#255337.067683836182170.002832212825417420.0154898133260248
HDAC2#3066313.41562023662630.0004140761399857210.00393822948583633
HMGN3#932438.178547723350590.001827766942164210.0109317461729864
IRF1#365937.63716375356390.002244692747297240.0128802519551111
MAX#414936.452555509007120.003721913834265510.0187494192039772
MEF2A#4205318.74323090964410.0001518243905622470.00195468288041549
MXI1#460139.96157162875930.001011470541259020.00723788776009257
MYC#460935.22228187160940.007020843755740150.0296250616543067
NFKB1#479035.488063424193840.006049381815655430.0270945787565502
NR2C2#7182332.61461090524092.88098172333076e-050.000606626714118834
NR3C1#2908314.9730233311730.0002978331194675480.00310464049945816
PAX5#507936.669565531177830.003370290999677260.0173744914218517
REST#597839.650028716128020.001112636247114590.00771751457876075
RXRA#6256320.07461713913330.0001235730348432220.0016607700663996
SIN3A#2594235.408884726815140.006318961977991520.0278458257392176
SIX5#147912317.0867153554590.0002004060546325010.00240383690591062
SP1#666735.69838137814090.005403962701712170.0248037470600385
SRF#6722313.79717826216780.0003806615025800190.00376690417547419
TAF7#6879311.43306940492390.0006690181981945830.0054604244764961
TCF12#6938310.63446490218640.0008313523990202070.00632240684491891
YY1#752834.911170749853860.008441455341808260.0331410102414523
ZBTB7A#5134137.35190930787590.002516255860282270.0141045108304004
ZNF143#7702313.50087655222790.0004062804962997170.00390605990546314



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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