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{{Coexpression_clusters
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|full_id=C2948_rhabdomyosarcoma_rectum_Saos2_teratocarcinoma_cerebellum_mesothelioma_gastrointestinal
|id=C2948
|ontology_enrichment_celltype=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0007023!6.83e-26!115;UBERON:0001017!2.56e-25!82;UBERON:0000073!3.11e-25!94;UBERON:0001016!3.11e-25!94;UBERON:0005743!3.68e-24!86;UBERON:0001049!1.95e-21!57;UBERON:0005068!1.95e-21!57;UBERON:0006241!1.95e-21!57;UBERON:0007135!1.95e-21!57;UBERON:0000955!8.00e-20!69;UBERON:0006238!8.00e-20!69;UBERON:0002346!4.09e-18!90;UBERON:0002616!4.57e-18!59;UBERON:0003075!9.14e-17!86;UBERON:0007284!9.14e-17!86;UBERON:0002780!2.45e-16!41;UBERON:0001890!2.45e-16!41;UBERON:0006240!2.45e-16!41;UBERON:0002020!3.96e-16!34;UBERON:0003528!3.96e-16!34;UBERON:0003080!6.46e-16!42;UBERON:0001893!9.04e-16!34;UBERON:0002791!1.94e-15!33;UBERON:0001869!5.48e-15!32;UBERON:0000924!3.64e-14!173;UBERON:0006601!3.64e-14!173;UBERON:0004121!4.55e-13!169;UBERON:0000956!2.46e-12!25;UBERON:0000203!2.46e-12!25;UBERON:0003056!4.47e-12!61;UBERON:0002619!8.66e-12!22;UBERON:0000033!9.70e-12!123;UBERON:0000153!1.21e-11!129;UBERON:0007811!1.21e-11!129;UBERON:0001950!5.95e-11!20;UBERON:0000481!1.20e-07!347;UBERON:0000064!3.84e-07!219;UBERON:0003076!9.13e-07!15;UBERON:0003057!9.13e-07!15
}}

Latest revision as of 12:16, 17 September 2013


Full id: C2948_rhabdomyosarcoma_rectum_Saos2_teratocarcinoma_cerebellum_mesothelioma_gastrointestinal



Phase1 CAGE Peaks

Hg19::chr9:98258815..98258820,-p@chr9:98258815..98258820
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Hg19::chr9:98271426..98271454,-p3@PTCH1
Hg19::chr9:98271460..98271496,-p@chr9:98271460..98271496
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Hg19::chr9:98271524..98271555,-p@chr9:98271524..98271555
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
nervous system1.07e-2689
central nervous system1.75e-2581
adult organism9.96e-25114
organ system subdivision4.91e-24223
neural tube1.84e-2156
neural rod1.84e-2156
future spinal cord1.84e-2156
neural keel1.84e-2156
brain5.17e-2068
future brain5.17e-2068
regional part of nervous system7.32e-2053
regional part of brain7.32e-2053
neurectoderm8.13e-1886
neural plate2.04e-1682
presumptive neural plate2.04e-1682
brain grey matter5.20e-1634
gray matter5.20e-1634
telencephalon1.04e-1534
regional part of forebrain1.21e-1541
forebrain1.21e-1541
anterior neural tube1.21e-1541
future forebrain1.21e-1541
regional part of telencephalon6.58e-1532
cerebral hemisphere7.11e-1532
anatomical cluster1.93e-14373
ectoderm-derived structure1.39e-13171
ectoderm1.39e-13171
presumptive ectoderm1.39e-13171
cerebral cortex6.63e-1225
pallium6.63e-1225
pre-chordal neural plate1.63e-1161
structure with developmental contribution from neural crest2.33e-11132
regional part of cerebral cortex2.52e-1122
neocortex1.38e-1020
ecto-epithelium9.54e-10104
multi-tissue structure1.91e-09342
gastrointestinal system2.98e-0825
intestine9.79e-0817
posterior neural tube4.46e-0715
chordal neural plate4.46e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.720743
MA0004.10.71247
MA0006.10.532262
MA0007.11.65296
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.11.30988
MA0050.10.69864
MA0051.10.820063
MA0052.14.13471
MA0055.11.8712
MA0056.10
MA0057.14.57701
MA0058.10.605914
MA0059.10.604454
MA0060.11.80156
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.13.33774
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.12.93423
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.10559
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.11.53138
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.24.91669
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538318.26835134422770.0002681660105721290.00286868687679428
FOSL2#2355312.69765045342130.000787568572975710.00616958252272803
FOXA1#316938.311064812039090.002740138182109850.0150421703864058
FOXA2#3170318.47284781449890.0002594484187437260.00278255631599671
IRF4#3662316.43588451505810.0003669431395554610.00366098343064891
MEF2A#4205314.0574231822330.0005830038854186610.00489023715277805
PAX5#507935.002174148383370.01196533174786410.0435295834755182
RFX5#599339.035933120396320.002144561191324070.0123914703325419
SMARCB1#6598313.68953683586810.0006305783409379340.00518354752847043
USF1#739134.771124457905970.01370465887188020.0483449593974293
USF2#739239.74414803880220.001718341848410070.0107282343559361



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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