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{{Coexpression_clusters
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|full_id=C2419_tubular_hepatoma_lung_signet_bile_pleomorphic_Mesenchymal
|id=C2419
|ontology_enrichment_celltype=CL:0000066!5.59e-17!254;CL:0000223!1.40e-09!59;CL:0000220!3.82e-09!246;CL:0002321!1.22e-08!248;CL:0002076!6.51e-08!43;CL:0000548!1.03e-07!679;CL:0000004!1.03e-07!679;CL:0000255!1.03e-07!679;CL:0000057!2.89e-07!75;CL:0000012!5.23e-07!682;CL:0000063!8.98e-07!578
|ontology_enrichment_disease=DOID:305!2.70e-08!106
|ontology_enrichment_uberon=UBERON:0000468!6.70e-20!659;UBERON:0004119!1.12e-19!169;UBERON:0000925!1.12e-19!169;UBERON:0006595!1.12e-19!169;UBERON:0000062!9.22e-19!511;UBERON:0001007!1.39e-18!155;UBERON:0001555!1.39e-18!155;UBERON:0007026!1.39e-18!155;UBERON:0000467!2.55e-18!625;UBERON:0000480!5.80e-18!626;UBERON:0004921!3.51e-16!129;UBERON:0004185!3.51e-16!129;UBERON:0000926!1.94e-15!448;UBERON:0004120!1.94e-15!448;UBERON:0006603!1.94e-15!448;UBERON:0003104!1.63e-14!238;UBERON:0009142!1.63e-14!238;UBERON:0000923!2.23e-14!604;UBERON:0005291!2.23e-14!604;UBERON:0006598!2.23e-14!604;UBERON:0002532!2.23e-14!604;UBERON:0000077!2.54e-14!130;UBERON:0002050!2.71e-14!605;UBERON:0005423!2.71e-14!605;UBERON:0002100!2.85e-14!216;UBERON:0000922!5.48e-13!612;UBERON:0000481!1.91e-12!347;UBERON:0000475!3.83e-12!365;UBERON:0000466!1.42e-11!126;UBERON:0001041!1.82e-11!98;UBERON:0005177!2.72e-11!107;UBERON:0001048!1.38e-10!168;UBERON:0009569!3.88e-10!113;UBERON:0005911!4.24e-09!82;UBERON:0003102!1.73e-08!95;UBERON:0005256!9.35e-08!143;UBERON:0000464!2.13e-07!104;UBERON:0009497!3.65e-07!25;UBERON:0000015!3.65e-07!25;UBERON:0002423!3.65e-07!25;UBERON:0006235!3.65e-07!25;UBERON:0004161!3.65e-07!25;UBERON:0002417!4.34e-07!61;UBERON:0000916!4.34e-07!61;UBERON:0009856!5.00e-07!26;UBERON:0007499!7.96e-07!25
}}

Latest revision as of 12:05, 17 September 2013


Full id: C2419_tubular_hepatoma_lung_signet_bile_pleomorphic_Mesenchymal



Phase1 CAGE Peaks

Hg19::chr17:48712143..48712165,+p2@ABCC3
Hg19::chr17:48712178..48712189,+p3@ABCC3
Hg19::chr17:48712191..48712198,+p5@ABCC3
Hg19::chr17:48712206..48712285,+p1@ABCC3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell3.72e-13253
endodermal cell8.17e-0958
fibroblast1.54e-0776
animal cell3.02e-07679
eukaryotic cell3.02e-07679
endo-epithelial cell3.26e-0742
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.05e-15160
endoderm1.05e-15160
presumptive endoderm1.05e-15160
digestive system3.70e-15145
digestive tract3.70e-15145
primitive gut3.70e-15145
organ1.13e-14503
organism subdivision3.96e-13264
subdivision of digestive tract6.25e-13118
multi-cellular organism2.52e-12656
trunk8.77e-12199
anatomical system1.11e-11624
anatomical group1.83e-11625
trunk region element2.71e-11101
subdivision of trunk7.14e-10112
immaterial anatomical entity3.15e-09117
multi-tissue structure4.10e-09342
endo-epithelium5.01e-0982
foregut1.17e-0887
abdominal segment of trunk6.81e-0860
abdomen6.81e-0860
primordium1.25e-07160
epithelial sac1.69e-0725
sac1.75e-0726
epithelium of foregut-midgut junction2.45e-0725
anatomical boundary2.45e-0725
hepatobiliary system2.45e-0725
foregut-midgut junction2.45e-0725
septum transversum2.45e-0725
mesenchyme4.48e-07160
entire embryonic mesenchyme4.48e-07160
gut epithelium5.42e-0754
embryo6.02e-07592
abdomen element7.03e-0754
abdominal segment element7.03e-0754
Disease
Ontology termp-valuen
carcinoma1.36e-07106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.92335
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.896009
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.11.22348
MA0106.12.01886
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.98562
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.16.10481
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.12.41215
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.23.96014
MA0065.21.7213
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.21.85039
MA0079.21.11128
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105147.971147625824820.0002476385788090830.00267956128597615
CTCF#1066445.360256373075030.001211145381643620.00817018553891476
E2F1#186944.907389214879320.001724022357361790.0106472219845372
EP300#203346.77394172622320.0004748459821442640.0043403150296836
HDAC2#3066413.41562023662633.0859005065161e-050.000626289084726069
HEY1#2346244.040111043105710.00375304636917980.018593255051979
HNF4A#3172423.13229036295373.48990320893214e-060.000115488593548056
HNF4G#3174428.75342252644681.46167379934821e-065.66440630538508e-05
JUND#372746.994663941871030.000417684217818580.00391479153053528
NR3C1#2908414.9730233311731.98868032687801e-050.000442848154922841
SUZ12#23512450.11578091106291.5827390373096e-078.79721566352197e-06
TAF1#687243.343046285745290.008005664898701650.0322011799097054
TBP#690843.706770687096390.005296377814784350.0244021705751836
TFAP2C#7022410.80922860986027.32289634782688e-050.00114490414920762
USF1#739146.361499277207960.0006105011399140830.00507765617197475



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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