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{{Coexpression_clusters
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|full_id=C1298_ductus_seminal_Fibroblast_kidney_uterus_epididymis_mesenchymal
|id=C1298
}}

Latest revision as of 11:41, 17 September 2013


Full id: C1298_ductus_seminal_Fibroblast_kidney_uterus_epididymis_mesenchymal



Phase1 CAGE Peaks

Hg19::chr10:119301691..119301711,-p7@EMX2OS
Hg19::chr10:119301716..119301729,-p10@EMX2OS
Hg19::chr10:119301735..119301746,-p9@EMX2OS
Hg19::chr10:119301771..119301798,-p1@EMX2OS
Hg19::chr10:119301800..119301823,-p2@EMX2OS
Hg19::chr10:119303078..119303169,+p2@EMX2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
skin fibroblast3.89e-1623
fat cell6.12e-1115
fibroblast3.52e-0876
preadipocyte4.02e-0712
Uber Anatomy
Ontology termp-valuen
adult organism6.54e-25114
regional part of forebrain6.77e-2341
forebrain6.77e-2341
anterior neural tube6.77e-2341
future forebrain6.77e-2341
telencephalon2.25e-2234
regional part of nervous system6.39e-2253
regional part of brain6.39e-2253
neural tube8.67e-2256
neural rod8.67e-2256
future spinal cord8.67e-2256
neural keel8.67e-2256
brain grey matter9.70e-2234
gray matter9.70e-2234
cerebral hemisphere3.18e-2132
regional part of telencephalon6.92e-2132
integument4.63e-2046
integumental system4.63e-2046
central nervous system1.58e-1881
brain1.87e-1868
future brain1.87e-1868
pre-chordal neural plate1.38e-1761
neurectoderm5.76e-1786
ecto-epithelium5.76e-17104
neural plate5.95e-1782
presumptive neural plate5.95e-1782
skin of body1.22e-1641
nervous system2.05e-1689
cerebral cortex2.55e-1625
pallium2.55e-1625
regional part of cerebral cortex3.92e-1422
neocortex1.63e-1220
ectoderm-derived structure1.31e-11171
ectoderm1.31e-11171
presumptive ectoderm1.31e-11171
structure with developmental contribution from neural crest1.60e-11132
adipose tissue3.34e-0814
surface structure3.47e-0899
tissue1.10e-07773
basal ganglion1.81e-079
nuclear complex of neuraxis1.81e-079
aggregate regional part of brain1.81e-079
collection of basal ganglia1.81e-079
cerebral subcortex1.81e-079
multi-cellular organism2.09e-07656
neural nucleus7.12e-079
nucleus of brain7.12e-079
organ part8.07e-07218


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00461978
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.262822
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.12.08744
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.808182
MA0056.10
MA0057.11.41984
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.11.24837
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.51617
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.11.15882
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.14.32919
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.11.34409
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.226048
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.347815
MA0146.10.441872
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.20.621793
MA0039.20.569061
MA0138.20.765223
MA0002.20.709311
MA0137.20.414885
MA0104.20.26661
MA0047.20.695777
MA0112.20.680553
MA0065.20.109623
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.132326
MA0155.10.65596
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.11.87239
MA0163.11.60684
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.25.1832
MA0102.21.58513
MA0258.10.289793
MA0259.10.893594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488552.26416694944016.08099221910156e-094.81860960827578e-07
JUND#372755.828886618225860.0003155682485030750.00323399394616943
SP1#666754.748651148450750.0008523704027326610.00641729472974311
SUZ12#23512650.11578091106296.2866744827465e-116.96999996075968e-09
TCF12#693847.089643268124280.001002991572657710.00718656948798012
YY1#752854.092642291544880.001743365462849530.0107222981905978
ZNF263#1012756.85153469750890.0001434607953814120.00186726096820031



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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