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{{Coexpression_clusters
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protein signal transduction!0.0128826114474228!8874;57381$GO:0007265!Ras protein signal 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|full_id=C1376_Endothelial_adipose_Lymphatic_Aortic_Smooth_breast_Hepatic
|id=C1376
}}

Latest revision as of 11:43, 17 September 2013


Full id: C1376_Endothelial_adipose_Lymphatic_Aortic_Smooth_breast_Hepatic



Phase1 CAGE Peaks

Hg19::chr13:111855420..111855431,+p9@ARHGEF7
Hg19::chr14:63671154..63671198,+p1@RHOJ
Hg19::chr14:63671393..63671437,+p2@RHOJ
Hg19::chr1:79472365..79472443,-p1@ELTD1
Hg19::chr6:153019023..153019043,+p2@MYCT1
Hg19::chr6:153019069..153019091,+p1@MYCT1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007266Rho protein signal transduction0.0128826114474228
GO:0007265Ras protein signal transduction0.0337873442676661



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm6.23e-4483
vasculature1.08e-4078
vascular system1.08e-4078
circulatory system2.47e-40112
vessel5.01e-4068
cardiovascular system6.55e-39109
epithelial tube open at both ends1.65e-3859
blood vessel1.65e-3859
blood vasculature1.65e-3859
vascular cord1.65e-3859
tube5.14e-37192
anatomical conduit1.90e-34240
anatomical cluster1.15e-32373
adult organism2.09e-30114
artery6.70e-2842
arterial blood vessel6.70e-2842
arterial system6.70e-2842
epithelial tube1.32e-27117
cell layer4.56e-26309
epithelium2.96e-25306
systemic artery4.84e-2233
systemic arterial system4.84e-2233
structure with developmental contribution from neural crest9.95e-18132
multi-cellular organism3.20e-16656
blood vessel endothelium1.90e-1518
endothelium1.90e-1518
cardiovascular system endothelium1.90e-1518
multi-tissue structure4.02e-15342
neural plate6.22e-1582
presumptive neural plate6.22e-1582
aorta1.02e-1421
aortic system1.02e-1421
anatomical system2.58e-14624
primary circulatory organ3.69e-1427
anatomical group3.92e-14625
neurectoderm5.74e-1486
neural tube7.22e-1456
neural rod7.22e-1456
future spinal cord7.22e-1456
neural keel7.22e-1456
unilaminar epithelium1.09e-13148
heart6.04e-1324
primitive heart tube6.04e-1324
primary heart field6.04e-1324
anterior lateral plate mesoderm6.04e-1324
heart tube6.04e-1324
heart primordium6.04e-1324
cardiac mesoderm6.04e-1324
cardiogenic plate6.04e-1324
heart rudiment6.04e-1324
regional part of nervous system6.97e-1353
regional part of brain6.97e-1353
muscle tissue8.26e-1364
musculature8.26e-1364
musculature of body8.26e-1364
simple squamous epithelium2.73e-1222
germ layer4.15e-12560
germ layer / neural crest4.15e-12560
embryonic tissue4.15e-12560
presumptive structure4.15e-12560
germ layer / neural crest derived structure4.15e-12560
epiblast (generic)4.15e-12560
skeletal muscle tissue4.29e-1262
striated muscle tissue4.29e-1262
myotome4.29e-1262
embryonic structure5.72e-12564
central nervous system8.29e-1281
brain1.03e-1168
future brain1.03e-1168
epithelial vesicle3.20e-1178
nervous system3.40e-1189
squamous epithelium4.04e-1125
regional part of forebrain1.30e-1041
forebrain1.30e-1041
anterior neural tube1.30e-1041
future forebrain1.30e-1041
paraxial mesoderm2.10e-1072
presumptive paraxial mesoderm2.10e-1072
developing anatomical structure2.27e-10581


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00461978
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.0254709
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.12.18297
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.11.3446
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.0586456
MA0056.10
MA0057.10.147053
MA0058.10.458909
MA0059.10.457555
MA0060.10.737586
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.959858
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.32124
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.22.01717
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.226048
MA0140.11.50842
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.347815
MA0146.10.0213085
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.20.621793
MA0039.20.00570825
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.26661
MA0047.20.695777
MA0112.20.101413
MA0065.20.354331
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.132326
MA0155.10.0961854
MA0156.11.88357
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.0383129
MA0163.10.0270301
MA0164.10.738243
MA0080.21.02158
MA0018.20.709805
MA0099.20.629739
MA0079.25.9246e-06
MA0102.21.58513
MA0258.10.289793
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235357.498296090745349.22669120642035e-050.00134303331415656
GATA2#262448.496621155702660.0004993024497617180.00440949167517877
JUN#372548.341886128224220.0005360662548571720.00463232033683834
POLR2A#543062.147453176558070.01019570676818780.0380092600093795



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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