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{{UBERON
{{UBERON
|id=UBERON:0002102
|alt_id=UBERON:FMA_7183-MA_0000025-MIAA_0000394-XAO_0003030
|name=forelimb
|anatomical_img_id=FMA:7183
|namespace=
|def="A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts." [UBERONREF:0000003, Wikipedia:Forelimb]
|xref=AAO:0000205;;BTO:0001729;;EFO:0000882;;EHDAA2:0002133;;EHDAA:6208;;EMAPA:17412;;EV:0100014;;FMA:24878;;GAID:1215;;GAID:51;;galen:UpperExtremity;;MA:0000025;;MAT:0000394;;MESH:A.13.395;;MIAA:0000394;;ncithesaurus:Upper_Extremity;;SCTID:182245002;;VHOG:0000338;;VSAO:0000148;;XAO:0003030
|is_a=UBERON:0002101;;UBERON:0004710
|synonym="anteriormost limb" EXACT [];;"fore limb" EXACT [];;"foreleg" RELATED [];;"forelimb" EXACT [];;"free part of upper limb" EXACT [FMA:24878];;"free upper limb" EXACT [FMA:24878, UBERONREF:0000003];;"membrum superius" EXACT [FMA:7183, FMA:TA];;"pectoral limb" EXACT [];;"superior member" EXACT [];;"upper extremity" EXACT [];;"upper limb" EXACT []
|comment=AO notes: note that this corresponds to FMA:'free upper limb' (a limb segment), NOT 'upper limb'. Both MA and FMA consider shoulder (and shoulder bones) part of upper limb. Usage notes:  Note distinction between arm and forelimb. hand is part of forelimb, but not part of arm
|comment=AO notes: note that this corresponds to FMA:'free upper limb' (a limb segment), NOT 'upper limb'. Both MA and FMA consider shoulder (and shoulder bones) part of upper limb. Usage notes:  Note distinction between arm and forelimb. hand is part of forelimb, but not part of arm
|alt_id=UBERON:FMA_7183-MA_0000025-MIAA_0000394-XAO_0003030
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts." [UBERONREF:0000003, Wikipedia:Forelimb]
|subset=uberon_slim
|derives_from=
|derives_from=
|develops_from=
|develops_from=UBERON:0005417
|disjoint_from=
|has_quality=
|has_quality=
|id=UBERON:0002102
|is_a=UBERON:0002101 ;;UBERON:0004710
|is_obsolete=
|located_in=
|located_in=
|part_of=
|name=forelimb
|namespace=FANTOM
|obo_creation_date=
|part_of=UBERON:0010708;;UBERON:0000153;;UBERON:0010708
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Upper limb, which connects the manus with the pectoral girdle.[AAO]" xsd:string
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Upper limb, which connects the manus with the pectoral girdle.[AAO]" xsd:string
|is_obsolete=
|subset=uberon_slim
|preceded_by=
|synonym="anteriormost limb" EXACT [];;"fore limb" EXACT [];;"foreleg" RELATED [];;"forelimb" EXACT [];;"free part of upper limb" EXACT [FMA:24878];;"free upper limb" EXACT [FMA:24878, UBERONREF:0000003];;"membrum superius" EXACT [FMA:7183, FMA:TA];;"pectoral limb" EXACT [];;"superior member" EXACT [];;"upper extremity" EXACT [];;"upper limb" EXACT []
|union_of=
|xref=AAO:0000205;;BTO:0001729;;EFO:0000882;;EHDAA2:0002133;;EHDAA:6208;;EMAPA:17412;;EV:0100014;;FMA:24878;;GAID:1215;;GAID:51;;galen:UpperExtremity;;MA:0000025;;MAT:0000394;;MESH:A.13.395;;MIAA:0000394;;ncithesaurus:Upper_Extremity;;SCTID:182245002;;VHOG:0000338;;VSAO:0000148;;XAO:0003030
}}
}}

Latest revision as of 17:26, 12 September 2014

Name:forelimb
Namespace:FANTOM
Definition:"A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts." [UBERONREF:0000003, Wikipedia:Forelimb]
Xrefs:
links:

AAO:0000205
BTO:0001729
EFO:0000882
EHDAA2:0002133
EHDAA:6208
EMAPA:17412
EV:0100014
FMA:24878
GAID:1215
GAID:51
galen:UpperExtremity
MA:0000025
MAT:0000394
MESH:A.13.395
MIAA:0000394
ncithesaurus:Upper_Extremity
SCTID:182245002
VHOG:0000338
VSAO:0000148

XAO:0003030
Synonyms: "anteriormost limb" EXACT []
"fore limb" EXACT []
"foreleg" RELATED []
"forelimb" EXACT []
"free part of upper limb" EXACT [FMA:24878]
"free upper limb" EXACT [FMA:24878, UBERONREF:0000003]
"membrum superius" EXACT [FMA:7183, FMA:TA]
"pectoral limb" EXACT []
"superior member" EXACT []
"upper extremity" EXACT []
"upper limb" EXACT []
Comments:AO notes: note that this corresponds to FMA:'free upper limb' (a limb segment), NOT 'upper limb'. Both MA and FMA consider shoulder (and shoulder bones) part of upper limb. Usage notes: Note distinction between arm and forelimb. hand is part of forelimb, but not part of arm
Alt_id: UBERON:FMA_7183-MA_0000025-MIAA_0000394-XAO_0003030
Subset: uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0002101(limb),UBERON:0004710(pectoral appendage)
develops_from:UBERON:0005417(forelimb bud)
part_of:UBERON:0010708(pectoral complex),UBERON:0000153(anterior region of body),UBERON:0010708(pectoral complex)



Children

is a:UBERON:0000024 (forelimb wing)
derives from:FF:0011277 (mouse forelimb- embryo E17 sample),FF:0011278 (mouse forelimb- embryo E18 sample),FF:0011314 (mouse forelimb- embryo E11 sample),FF:0011322 (mouse forelimb- embryo E12 sample),FF:0011331 (mouse forelimb- embryo E13 sample),FF:0011342 (mouse forelimb- embryo E14 sample),FF:0011351 (mouse forelimb- embryo E15 sample)
part of:UBERON:0002398 (manus),UBERON:0003531 (forelimb skin),UBERON:0008785 (upper limb segment)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002102 (forelimb), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.33e-86FFCP PHASE1:Mm9::chr2:74499300..74499309,-#_f0d8f2944531a749fb1a8d195dc6650ep5@Evx2
1.33e-86FFCP PHASE2:Mm9::chr2:74499300..74499309,-#_f0d8f2944531a749fb1a8d195dc6650ep5@Evx2
2.4e-74FFCP PHASE1:Mm9::chr2:165983686..165983720,-#_9568b07d0918292100cb409905703231p@chr2:165983686..165983720, -
2.4e-74FFCP PHASE2:Mm9::chr5:120256413..120256428,-#_9568b07d0918292100cb409905703231p@chr5:120256413..120256428, -
2.4e-74FFCP PHASE1:Mm9::chr15:51484092..51484121,-#_9568b07d0918292100cb409905703231p@chr15:51484092..51484121, -
2.4e-74FFCP PHASE1:Mm9::chr5:120256413..120256428,-#_9568b07d0918292100cb409905703231p@chr5:120256413..120256428, -
2.4e-74FFCP PHASE2:Mm9::chr15:51484092..51484121,-#_9568b07d0918292100cb409905703231p@chr15:51484092..51484121, -
2.4e-74FFCP PHASE2:Mm9::chr2:165983686..165983720,-#_9568b07d0918292100cb409905703231p@chr2:165983686..165983720, -
1.21e-61FFCP PHASE2:Mm9::chr2:74505324..74505330,+#_a1a79208981c5772e1cd95371cc2a16bp@chr2:74505324..74505330, +
1.21e-61FFCP PHASE1:Mm9::chr2:74505324..74505330,+#_a1a79208981c5772e1cd95371cc2a16bp@chr2:74505324..74505330, +
2.24e-61FFCP PHASE2:Mm9::chr2:74506264..74506286,+#_5151331ec7c551b9fcf68952b2214549p1@Hoxd13
2.24e-61FFCP PHASE1:Mm9::chr2:74506264..74506286,+#_5151331ec7c551b9fcf68952b2214549p1@Hoxd13
3.63e-52FFCP PHASE2:Mm9::chr2:74513064..74513089,+#_2ecdc27ed7f4086441e7b5d93e475847p2@Hoxd12
3.63e-52FFCP PHASE1:Mm9::chr2:74513064..74513089,+#_2ecdc27ed7f4086441e7b5d93e475847p2@Hoxd12
4.62e-52FFCP PHASE1:Mm9::chr2:74499251..74499258,-#_c125e5e5e8f72295540ee1b6d6ba7493p4@Evx2
4.62e-52FFCP PHASE2:Mm9::chr2:74499251..74499258,-#_c125e5e5e8f72295540ee1b6d6ba7493p4@Evx2
5.88e-52FFCP PHASE2:Mm9::chr2:33574246..33574257,-#_2014925bfde2ad059d5c03728be68fd2p3@ENSMUST00000130532
5.88e-52FFCP PHASE1:Mm9::chr2:33574246..33574257,-#_2014925bfde2ad059d5c03728be68fd2p3@ENSMUST00000130532
5.28e-50FFCP PHASE2:Mm9::chr2:74521516..74521525,+#_742a44e4cbc08cf391376e6eb378ba61p1@ENSMUST00000136302
5.28e-50FFCP PHASE1:Mm9::chr2:74521516..74521525,+#_742a44e4cbc08cf391376e6eb378ba61p1@ENSMUST00000136302
9.21e-50FFCP PHASE1:Mm9::chr6:51009701..51009744,-#_75845dcde6fb71066e7aac0bb862a527p@chr6:51009701..51009744, -
9.21e-50FFCP PHASE2:Mm9::chr6:51009701..51009744,-#_75845dcde6fb71066e7aac0bb862a527p@chr6:51009701..51009744, -
2.92e-48FFCP PHASE2:Mm9::chr10:97069737..97069749,+#_f535a560ec87a2ff8b7a9fd2cb09efa3p5@Kera
2.92e-48FFCP PHASE1:Mm9::chr10:97069737..97069749,+#_f535a560ec87a2ff8b7a9fd2cb09efa3p5@Kera
4.71e-48FFCP PHASE1:Mm9::chr6:52210816..52210831,-#_98cebc32fe6151d0ba23bcd9f4b51727p2@Hoxa13
4.71e-48FFCP PHASE2:Mm9::chr6:52210816..52210831,-#_98cebc32fe6151d0ba23bcd9f4b51727p2@Hoxa13
6.47e-48FFCP PHASE2:Mm9::chr2:74513149..74513159,+#_65afddc71df64195f4c73055756ee429p@chr2:74513149..74513159, +
6.47e-48FFCP PHASE1:Mm9::chr2:74513149..74513159,+#_65afddc71df64195f4c73055756ee429p@chr2:74513149..74513159, +
1.4e-44FFCP PHASE1:Mm9::chr1:165288513..165288518,+#_20e38d848bfb14fe0cd2e0ab448ccb3ep@chr1:165288513..165288518, +
1.4e-44FFCP PHASE2:Mm9::chr1:165288513..165288518,+#_20e38d848bfb14fe0cd2e0ab448ccb3ep@chr1:165288513..165288518, +
2.07e-41FFCP PHASE2:Mm9::chr1:164064835..164064864,-#_6468e6a952f30f862b69d45a42534855p3@Dnm3
2.07e-41FFCP PHASE1:Mm9::chr1:164064835..164064864,-#_6468e6a952f30f862b69d45a42534855p3@Dnm3
2.91e-40FFCP PHASE2:Mm9::chr2:33574267..33574279,-#_cf090ac862f063d7337535027f9b7ebfp1@ENSMUST00000130532
2.91e-40FFCP PHASE1:Mm9::chr2:33574267..33574279,-#_cf090ac862f063d7337535027f9b7ebfp1@ENSMUST00000130532
3.67e-40FFCP PHASE1:Mm9::chr2:33574309..33574319,-#_407a542867de5283f28f00fca9b09cf0p4@ENSMUST00000130532
3.67e-40FFCP PHASE2:Mm9::chr2:33574309..33574319,-#_407a542867de5283f28f00fca9b09cf0p4@ENSMUST00000130532
5.46e-39FFCP PHASE2:Mm9::chr6:52195000..52195013,+#_7c70997785a5f0c0768529b863c560fdp3@Hoxa11as
5.46e-39FFCP PHASE1:Mm9::chr6:52195000..52195013,+#_7c70997785a5f0c0768529b863c560fdp3@Hoxa11as
6.59e-38FFCP PHASE1:Mm9::chr2:74512009..74512012,+#_8c59ed92264d2cc6b76b55fef32526f6p@chr2:74512009..74512012, +
6.59e-38FFCP PHASE2:Mm9::chr2:74512009..74512012,+#_8c59ed92264d2cc6b76b55fef32526f6p@chr2:74512009..74512012, +
1.94e-35FFCP PHASE2:Mm9::chr2:33496847..33496857,+#_c4ee3df0f15550b3ceee2e3f0b4ef4bcp3@ENSMUST00000147294, p3@uc008jia.1
1.94e-35FFCP PHASE1:Mm9::chr2:33496847..33496857,+#_c4ee3df0f15550b3ceee2e3f0b4ef4bcp3@ENSMUST00000147294, p3@uc008jia.1
9.74e-35FFCP PHASE2:Mm9::chr13:89680110..89680115,+#_5742e7fc09cc8d8631cbfa474a4321dcp6@Hapln1
9.74e-35FFCP PHASE1:Mm9::chr13:89680110..89680115,+#_5742e7fc09cc8d8631cbfa474a4321dcp6@Hapln1
2.95e-34FFCP PHASE2:Mm9::chr9:96754986..96754989,-#_806e0a6d43f550407a3e1d793f359b66p3@Acpl2
2.95e-34FFCP PHASE1:Mm9::chr9:96754986..96754989,-#_806e0a6d43f550407a3e1d793f359b66p3@Acpl2
6.28e-34FFCP PHASE2:Mm9::chr8:23734491..23734495,+#_4fb2a7c9707f6202867ca8d974feccc0p1@Dkk4
6.28e-34FFCP PHASE1:Mm9::chr8:23734491..23734495,+#_4fb2a7c9707f6202867ca8d974feccc0p1@Dkk4
7.62e-34FFCP PHASE2:Mm9::chr2:155770985..155770995,-#_26e52ffd228c5c5532d0b97f64a46c6cp2@Gdf5
7.62e-34FFCP PHASE1:Mm9::chr2:155770985..155770995,-#_26e52ffd228c5c5532d0b97f64a46c6cp2@Gdf5
2.0e-33FFCP PHASE1:Mm9::chr18:80910310..80910329,-#_960ca435997f1a06b6bcc7d1bd33a899p@chr18:80910310..80910329, -
2.0e-33FFCP PHASE2:Mm9::chr18:80910310..80910329,-#_960ca435997f1a06b6bcc7d1bd33a899p@chr18:80910310..80910329, -
1.89e-32FFCP PHASE2:Mm9::chr6:52210774..52210787,-#_d7ae9901c26ee9ef1e66e31c0728f48ep1@Hoxa13
1.89e-32FFCP PHASE1:Mm9::chr6:52210774..52210787,-#_d7ae9901c26ee9ef1e66e31c0728f48ep1@Hoxa13
6.43e-32FFCP PHASE2:Mm9::chr2:33498116..33498124,+#_c2c27d1e59c937731f68c5fea537aaa3p@chr2:33498116..33498124, +
6.43e-32FFCP PHASE1:Mm9::chr2:33498116..33498124,+#_c2c27d1e59c937731f68c5fea537aaa3p@chr2:33498116..33498124, +
7.44e-32FFCP PHASE2:Mm9::chr2:33496574..33496588,+#_c6978af42d3deaddb84d54248a6aca45p4@ENSMUST00000152118, p4@uc008jhz.1
7.44e-32FFCP PHASE1:Mm9::chr2:33496574..33496588,+#_c6978af42d3deaddb84d54248a6aca45p4@ENSMUST00000152118, p4@uc008jhz.1
1.09e-30FFCP PHASE1:Mm9::chr2:74520075..74520087,+#_0255dc8efd1b8e37f3c7b91fe28ed866p6@Hoxd11
1.09e-30FFCP PHASE2:Mm9::chr2:74520075..74520087,+#_0255dc8efd1b8e37f3c7b91fe28ed866p6@Hoxd11
2.22e-30FFCP PHASE1:Mm9::chr12:34649201..34649205,+#_36e90950c22e14a13eb4c77717937058p@chr12:34649201..34649205, +
2.22e-30FFCP PHASE2:Mm9::chr12:34649201..34649205,+#_36e90950c22e14a13eb4c77717937058p@chr12:34649201..34649205, +
1.6e-29FFCP PHASE2:Mm9::chr5:120285104..120285113,+#_8e131bb673c371c077515a9c6d533f47p5@Tbx5
1.6e-29FFCP PHASE1:Mm9::chr5:120285104..120285113,+#_8e131bb673c371c077515a9c6d533f47p5@Tbx5
4.13e-29FFCP PHASE2:Mm9::chr5:120246556..120246565,+#_e26b41d17015e679cd6a0409497ae98ap@chr5:120246556..120246565, +
4.13e-29FFCP PHASE1:Mm9::chr5:120246556..120246565,+#_e26b41d17015e679cd6a0409497ae98ap@chr5:120246556..120246565, +
4.91e-29FFCP PHASE2:Mm9::chr5:120246522..120246553,+#_e129c6f94e91b5297bc7ae98810488edp@chr5:120246522..120246553, +
4.91e-29FFCP PHASE1:Mm9::chr5:120246522..120246553,+#_e129c6f94e91b5297bc7ae98810488edp@chr5:120246522..120246553, +
5.59e-29FFCP PHASE2:Mm9::chr16:77329743..77329754,+#_f710738b3571092e90623f064e34fa0cp14@2810055G20Rik
5.59e-29FFCP PHASE1:Mm9::chr16:77329743..77329754,+#_f710738b3571092e90623f064e34fa0cp14@2810055G20Rik
8.27e-29FFCP PHASE1:Mm9::chr3:29912310..29912321,-#_7848fe93286d0f4147259a69e27b4187p23@Mecom
8.27e-29FFCP PHASE2:Mm9::chr3:29912310..29912321,-#_7848fe93286d0f4147259a69e27b4187p23@Mecom
6.5e-28FFCP PHASE2:Mm9::chr3:99044251..99044260,+#_5825db1b00a41d4989534e250d1fdde9p8@Tbx15
6.5e-28FFCP PHASE1:Mm9::chr3:99044251..99044260,+#_5825db1b00a41d4989534e250d1fdde9p8@Tbx15
3.95e-27FFCP PHASE2:Mm9::chr15:97807283..97807309,-#_47922b095459e378e151c321c284f917p@chr15:97807283..97807309, -
3.95e-27FFCP PHASE1:Mm9::chr15:97807283..97807309,-#_47922b095459e378e151c321c284f917p@chr15:97807283..97807309, -
5.23e-27FFCP PHASE2:Mm9::chr1:165244244..165244254,-#_74d58d34def530cb6fc75b3a47b28db2p8@Prrx1
5.23e-27FFCP PHASE1:Mm9::chr1:165244244..165244254,-#_74d58d34def530cb6fc75b3a47b28db2p8@Prrx1
1.4e-26FFCP PHASE2:Mm9::chr5:42155277..42155281,-#_8f6a2eb24df77c1ca18a5f7b5db66259p2@Nkx3-2
1.4e-26FFCP PHASE1:Mm9::chr5:42155277..42155281,-#_8f6a2eb24df77c1ca18a5f7b5db66259p2@Nkx3-2
1.64e-26FFCP PHASE1:Mm9::chr16:95807232..95807250,-#_079d5a351fe426c10e8089b001d34971p@chr16:95807232..95807250, -
1.64e-26FFCP PHASE2:Mm9::chr16:95807232..95807250,-#_079d5a351fe426c10e8089b001d34971p@chr16:95807232..95807250, -
7.57e-26FFCP PHASE2:Mm9::chr4:125973415..125973418,+#_2adcd780b85c1c483a4d0238ff941eb0p@chr4:125973415..125973418, +
7.57e-26FFCP PHASE2:Mm9::chr3:37606335..37606337,-#_2adcd780b85c1c483a4d0238ff941eb0p@chr3:37606335..37606337, -
7.57e-26FFCP PHASE1:Mm9::chr3:37606335..37606337,-#_2adcd780b85c1c483a4d0238ff941eb0p@chr3:37606335..37606337, -
7.57e-26FFCP PHASE1:Mm9::chr3:86116124..86116132,+#_2adcd780b85c1c483a4d0238ff941eb0p@chr3:86116124..86116132, +
7.57e-26FFCP PHASE2:Mm9::chr3:86116124..86116132,+#_2adcd780b85c1c483a4d0238ff941eb0p@chr3:86116124..86116132, +
7.57e-26FFCP PHASE1:Mm9::chr4:125973415..125973418,+#_2adcd780b85c1c483a4d0238ff941eb0p@chr4:125973415..125973418, +
1.07e-25FFCP PHASE1:Mm9::chr17:68300324..68300336,-#_17a07503088e277c8c4c88516e18663ep5@Arhgap28
1.07e-25FFCP PHASE2:Mm9::chr17:68300324..68300336,-#_17a07503088e277c8c4c88516e18663ep5@Arhgap28
2.33e-25FFCP PHASE1:Mm9::chr7:75096968..75096978,+#_bcda3de63c0252a346aa0770d75d3a3fp9@Igf1r
2.33e-25FFCP PHASE2:Mm9::chr7:75096968..75096978,+#_bcda3de63c0252a346aa0770d75d3a3fp9@Igf1r
2.93e-25FFCP PHASE2:Mm9::chr15:101936581..101936594,+#_c5d02982519cf6c1d724b173427f6aa7p@chr15:101936581..101936594, +
2.93e-25FFCP PHASE1:Mm9::chr15:101936581..101936594,+#_c5d02982519cf6c1d724b173427f6aa7p@chr15:101936581..101936594, +
2.99e-25FFCP PHASE2:Mm9::chr17:23882313..23882330,-#_8313030b5d0b83ce249d108f61202ff0p@chr17:23882313..23882330, -
2.99e-25FFCP PHASE1:Mm9::chr17:23882313..23882330,-#_8313030b5d0b83ce249d108f61202ff0p@chr17:23882313..23882330, -
3.52e-25FFCP PHASE1:Mm9::chr2:155771018..155771042,-#_7feca5689396a266558283cfa70428fbp1@Gdf5
3.52e-25FFCP PHASE2:Mm9::chr2:155771018..155771042,-#_7feca5689396a266558283cfa70428fbp1@Gdf5
2.77e-24FFCP PHASE1:Mm9::chr15:77137392..77137399,-#_74ecbf71c40274e64452ea5113b0df61p16@Rbfox2
2.77e-24FFCP PHASE2:Mm9::chr15:77137392..77137399,-#_74ecbf71c40274e64452ea5113b0df61p16@Rbfox2










Property "Property value" (as page type) with input value "UBPROP:0000001 "Upper limb, which connects the manus with the pectoral girdle.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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