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Coexpression cluster:C4438: Difference between revisions

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{{Coexpression_clusters
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|full_id=C4438_Mast_placenta_chorionic_mesenchymal_chronic_testicular_mesothelioma
|id=C4438
|ontology_enrichment_celltype=CL:0000037!9.94e-29!172;CL:0000566!9.94e-29!172;CL:0002032!3.67e-28!165;CL:0000837!3.67e-28!165;CL:0000763!8.22e-24!112;CL:0000049!8.22e-24!112;CL:0000988!1.44e-23!182;CL:0002031!7.03e-23!124;CL:0000557!4.77e-21!71;CL:0000738!9.71e-21!140;CL:0002087!2.33e-20!119;CL:0000839!3.54e-19!70;CL:0002009!9.89e-18!65;CL:0002194!1.04e-16!63;CL:0000576!1.04e-16!63;CL:0000040!1.04e-16!63;CL:0000559!1.04e-16!63;CL:0000766!3.37e-15!76;CL:0000860!6.88e-13!45;CL:0002057!1.72e-11!42;CL:0000063!9.30e-07!578
|ontology_enrichment_disease=DOID:162!2.98e-11!235;DOID:14566!3.97e-11!239;DOID:2531!3.60e-09!51;DOID:0060083!3.60e-09!51;DOID:8692!6.85e-09!31;DOID:1240!1.62e-08!39;DOID:305!8.24e-08!106
|ontology_enrichment_uberon=UBERON:0002371!3.73e-16!80;UBERON:0002405!2.07e-14!115;UBERON:0002193!2.69e-14!112;UBERON:0001474!6.28e-14!86;UBERON:0002390!3.28e-13!102;UBERON:0003061!3.28e-13!102;UBERON:0004765!5.59e-09!101;UBERON:0001434!5.59e-09!101
}}

Latest revision as of 12:45, 17 September 2013


Full id: C4438_Mast_placenta_chorionic_mesenchymal_chronic_testicular_mesothelioma



Phase1 CAGE Peaks

Hg19::chr4:87857474..87857489,+p7@AFF1
Hg19::chr4:87857491..87857519,+p10@AFF1
Hg19::chr4:87857538..87857549,+p19@AFF1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
immune system6.51e-1693
bone marrow8.01e-1476
hemolymphoid system3.05e-12108
bone element6.11e-1282
hematopoietic system2.02e-1198
blood island2.02e-1198
skeletal element9.68e-1090
Disease
Ontology termp-valuen
cancer3.29e-12235
disease of cellular proliferation8.11e-12239
hematologic cancer6.21e-0951
immune system cancer6.21e-0951
carcinoma6.62e-09106
myeloid leukemia1.31e-0831
leukemia3.74e-0839


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.12.19699
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.12.07172
MA0141.10.712476
MA0142.14.12243
MA0143.11.00455
MA0144.12.26598
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.11.76247
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.11.51687
MA0155.12.02721
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.22.08754
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538324.35780179230366.91705216281876e-050.00110173861649021
CTCF#1066435.360256373075030.0064925092527670.0280786439955995
E2F6#187635.017155731697390.00791769806886330.0323760412127173
FOS#235338.99795530889440.001372499272417130.00900675158730585
FOSL2#2355316.93020060456170.0002060162053171620.00243836428684486
GATA1#2623313.56030814380040.0004009615963782630.00388965522609599
GATA2#2624312.7449317335540.0004829527704283790.00438410294574268
HDAC2#3066313.41562023662630.0004140761399857210.00392856994767158
HNF4A#3172323.13229036295378.07584663437677e-050.00123272924093493
HNF4G#3174328.75342252644684.20470658818262e-050.000759355613631687
JUN#3725312.51282919233630.0005103313992726250.00445751451105074
JUNB#3726330.61063265982113.4847716247536e-050.000681802292464671
JUND#372736.994663941871030.002921845042734990.015737729469737
MAX#414936.452555509007120.003721913834265510.0187187209350311
MXI1#460139.96157162875930.001011470541259020.00722205317963704
NFKB1#479035.488063424193840.006049381815655430.0270481799574124
POU2F2#545239.106124057742520.001324165192682130.00884688386377488
RXRA#6256213.38307809275550.007196434429465730.0298379616252718
TAL1#6886329.86861667744023.75103522793067e-050.00072159581538009
ZNF143#7702313.50087655222790.0004062804962997170.00390210858497757



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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