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{{Coexpression_clusters
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|full_id=C4256_transitionalcell_embryonic_acute_retinoblastoma_iPS_Hodgkin_chronic
|gostat_on_coexpression_clusters=GO:0007049!cell cycle!0.0353349536749479!2177;1871
|id=C4256
}}

Latest revision as of 12:42, 17 September 2013


Full id: C4256_transitionalcell_embryonic_acute_retinoblastoma_iPS_Hodgkin_chronic



Phase1 CAGE Peaks

Hg19::chr3:10068095..10068170,+p1@FANCD2
Hg19::chr6:20402070..20402082,+p5@E2F3
Hg19::chr6:20402102..20402152,+p1@E2F3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007049cell cycle0.0353349536749479



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell1.87e-16253
animal cell6.48e-15679
eukaryotic cell6.48e-15679
native cell1.19e-10722
neural cell3.45e-0725
neurectodermal cell4.96e-0759
Disease
Ontology termp-valuen
cancer2.49e-56235
disease of cellular proliferation2.76e-55239
cell type cancer8.12e-30143
organ system cancer5.82e-26137
carcinoma1.14e-23106
hematologic cancer3.15e-2351
immune system cancer3.15e-2351
leukemia1.91e-1939
myeloid leukemia1.35e-1531


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.14.40988
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.06172
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.14.27202
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.10.273764
MA0146.11.70974
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.21.15986
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.22.23118
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.22.26143
MA0099.20.902716
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.01905689364893
CHD2#1106310.34402283411690.0009033701102746880.00661806053219544
E2F1#186934.907389214879320.008460985347239390.0326446063275457
E2F4#1874312.66806031528440.0004917987006298980.00437988952801961
E2F6#187635.017155731697390.00791769806886330.0323292074679026
ELF1#199734.258097958807540.01295179875054610.046367288578764
ETS1#211339.728760922202340.001085840092584840.00763869415529218
FOXA1#3169311.08141974938550.000734755275698670.00582577484350845
FOXA2#3170216.42030916844350.004810682352105480.0225980683745578
GABPB1#255337.067683836182170.002832212825417420.0154517826502518
GTF2B#2959221.29588662288280.002878180589911410.0155869485418593
GTF2F1#2962312.73966087675770.0004835525047438590.00434947377856721
HDAC2#3066313.41562023662630.0004140761399857210.00392429201306431
HMGN3#932438.178547723350590.001827766942164210.0108936912442326
IRF1#365937.63716375356390.002244692747297240.012842854488604
IRF3#3661231.32130147432640.001339514673320110.00887787618776999
JUND#372736.994663941871030.002921845042734990.0157150362765578
KAT2A#26482410.7266666666677.8689746933917e-060.000222416197023853
MXI1#460139.96157162875930.001011470541259020.00721514731634116
MYC#460935.22228187160940.007020843755740150.0295308055177505
NFKB1#479035.488063424193840.006049381815655430.0270227282910709
NFYA#4800212.28372046655370.008516011403724430.0324837003284724
NFYB#4801211.17319550235760.01025467135054530.0381433015592135
PAX5#507936.669565531177830.003370290999677260.0173317160724454
POU2F2#545239.106124057742520.001324165192682130.00883840279660823
RDBP#79362102.4256026600170.0001264379392731220.00168345894183397
REST#597839.650028716128020.001112636247114590.00769502794599037
RFX5#5993312.04791082719510.0005717246050312580.00485686888115012
RXRA#6256320.07461713913330.0001235730348432220.00165565672687509
SIN3A#2594235.408884726815140.006318961977991520.0277603192705782
SP1#666735.69838137814090.005403962701712170.0247190110636001
SP2#6668217.43568699589640.004273568481769740.0203245545841325
SREBF1#6720231.33723296032550.00133816265136180.00887680190203095
STAT2#6773243.50918079096040.0006968990898868230.0056095139921919
TAF7#6879311.43306940492390.0006690181981945830.00544510533052089
THAP1#55145220.91276306856750.002983447413736940.0158722563518553
YY1#752834.911170749853860.008441455341808260.0330267908310149



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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