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{{Coexpression_clusters
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|full_id=C3784_Endothelial_Alveolar_Renal_Sebocyte_Fibroblast_Mesothelial_Prostate
|id=C3784
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}}

Latest revision as of 12:33, 17 September 2013


Full id: C3784_Endothelial_Alveolar_Renal_Sebocyte_Fibroblast_Mesothelial_Prostate



Phase1 CAGE Peaks

Hg19::chr19:3971050..3971128,-p1@DAPK3
Hg19::chr1:16085244..16085253,+p3@FBLIM1
Hg19::chr1:16085263..16085314,+p1@FBLIM1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
embryonic cell1.94e-31250
mesodermal cell1.51e-28121
contractile cell8.85e-1659
muscle cell8.79e-1455
muscle precursor cell1.07e-1358
myoblast1.07e-1358
multi-potent skeletal muscle stem cell1.07e-1358
smooth muscle cell1.16e-1343
smooth muscle myoblast1.16e-1343
meso-epithelial cell1.49e-1345
electrically responsive cell1.05e-1261
electrically active cell1.05e-1261
lining cell1.05e-1258
barrier cell1.05e-1258
epithelial cell1.52e-12253
non-terminally differentiated cell3.64e-12106
endothelial cell6.98e-1236
vascular associated smooth muscle cell1.56e-1132
endothelial cell of vascular tree1.61e-1024
fibroblast4.70e-0976
blood vessel endothelial cell9.56e-0918
embryonic blood vessel endothelial progenitor cell9.56e-0918
squamous epithelial cell1.14e-0863
somatic cell1.63e-08588
animal cell2.56e-08679
eukaryotic cell2.56e-08679
cardiocyte1.14e-0716
epithelial cell of nephron1.15e-0715
Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm2.78e-2783
vasculature3.56e-2678
vascular system3.56e-2678
epithelial tube8.54e-25117
vessel1.19e-2268
circulatory system3.12e-22112
cardiovascular system1.23e-21109
cell layer1.56e-21309
epithelium3.38e-21306
epithelial tube open at both ends1.19e-2059
blood vessel1.19e-2059
blood vasculature1.19e-2059
vascular cord1.19e-2059
multi-cellular organism9.46e-18656
anatomical cluster1.28e-17373
unilaminar epithelium1.62e-16148
artery5.53e-1642
arterial blood vessel5.53e-1642
arterial system5.53e-1642
epithelial vesicle1.06e-1578
mesenchyme1.72e-15160
entire embryonic mesenchyme1.72e-15160
organism subdivision1.99e-15264
multilaminar epithelium2.33e-1583
anatomical system3.46e-15624
anatomical group5.30e-15625
anatomical conduit2.00e-14240
trunk mesenchyme6.14e-14122
multi-tissue structure8.74e-14342
trunk5.63e-13199
dense mesenchyme tissue1.04e-1273
somite1.59e-1271
presomitic mesoderm1.59e-1271
presumptive segmental plate1.59e-1271
dermomyotome1.59e-1271
trunk paraxial mesoderm1.59e-1271
muscle tissue2.24e-1264
musculature2.24e-1264
musculature of body2.24e-1264
paraxial mesoderm2.38e-1272
presumptive paraxial mesoderm2.38e-1272
skeletal muscle tissue3.07e-1262
striated muscle tissue3.07e-1262
myotome3.07e-1262
systemic artery8.06e-1233
systemic arterial system8.06e-1233
compound organ8.29e-1268
tube1.33e-10192
developing anatomical structure1.01e-09581
embryo1.51e-09592
primary circulatory organ2.23e-0927
heart6.14e-0924
primitive heart tube6.14e-0924
primary heart field6.14e-0924
anterior lateral plate mesoderm6.14e-0924
heart tube6.14e-0924
heart primordium6.14e-0924
cardiac mesoderm6.14e-0924
cardiogenic plate6.14e-0924
heart rudiment6.14e-0924
blood vessel endothelium9.56e-0918
endothelium9.56e-0918
cardiovascular system endothelium9.56e-0918
urinary system structure1.41e-0847
primordium1.60e-08160
renal system1.61e-0848
embryonic structure2.77e-08564
simple squamous epithelium4.59e-0822
surface structure7.98e-0899
nephron epithelium1.15e-0715
renal tubule1.15e-0715
nephron tubule1.15e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.13.22681
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.17.37849
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.14.3182
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.17.32221
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.12.25834
MA0107.12.34614
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.23.37171
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.22.97249
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.13.71118
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.15.63764
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.218.6494
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SRF#6722313.79717826216780.0003806615025800190.00375020344004854



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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