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{{Coexpression_clusters
{
|full_id=C2891_Mesenchymal_uterus_smallcell_small_leiomyoma_cervix_acute
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Latest revision as of 12:15, 17 September 2013


Full id: C2891_Mesenchymal_uterus_smallcell_small_leiomyoma_cervix_acute



Phase1 CAGE Peaks

Hg19::chr7:27224795..27224840,-p2@HOXA11
Hg19::chr7:27224842..27224872,-p1@HOXA11
Hg19::chr7:27225007..27225030,+p2@HOXA11-AS1
Hg19::chr7:27225038..27225057,+p1@HOXA11-AS1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0001759induction of an organ0.00323796067349582
GO:0010092specification of organ identity0.00323796067349582
GO:0045168cell-cell signaling during cell fate commitment0.00323796067349582
GO:0031128induction0.00323796067349582
GO:0001656metanephros development0.00777110561638996
GO:0001822kidney development0.00925131620998805
GO:0001655urogenital system development0.00925131620998805
GO:0045165cell fate commitment0.0143684504886377
GO:0003002regionalization0.0156501432552298
GO:0007389pattern specification process0.0200753561756741
GO:0001501skeletal development0.0307606263982103
GO:0009887organ morphogenesis0.048839240158562



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
kidney tubule cell2.62e-0910
nephron tubule epithelial cell2.62e-0910
epithelial cell of nephron1.37e-0815
kidney cell1.60e-0817
kidney epithelial cell1.60e-0817
skin fibroblast2.90e-0823
osteoblast6.40e-0711
osteoprogenitor cell6.40e-0711
mesenchyme condensation cell6.40e-0711
Uber Anatomy
Ontology termp-valuen
renal system2.01e-1848
urinary system structure6.41e-1847
cavitated compound organ2.15e-1131
kidney4.12e-1126
kidney mesenchyme4.12e-1126
upper urinary tract4.12e-1126
kidney rudiment4.12e-1126
kidney field4.12e-1126
mesenchyme5.89e-10160
entire embryonic mesenchyme5.89e-10160
nephron tubule epithelium2.62e-0910
excretory tube3.04e-0916
kidney epithelium3.04e-0916
intermediate mesoderm9.67e-0928
nephron epithelium1.37e-0815
renal tubule1.37e-0815
nephron tubule1.37e-0815
nephron1.37e-0815
uriniferous tubule1.37e-0815
nephrogenic mesenchyme1.37e-0815
cloaca3.83e-0814
anal region3.83e-0814
embryonic cloaca3.83e-0814
terminal part of digestive tract3.83e-0814
primitive urogenital sinus3.83e-0814
proctodeum3.83e-0814
hindgut5.80e-0819
reproductive structure1.19e-0759
reproductive system1.19e-0759
genitourinary system2.63e-0715
umbilical blood vessel4.47e-079
sex gland8.42e-0712
male reproductive gland8.42e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.12.526
MA0056.10
MA0057.11.98521
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.11.70187
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.13.51257
MA0106.12.01886
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.13665
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.22.43626
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.22.00408
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105147.971147625824820.0002476385788090830.00268679882944544
MAX#414946.452555509007120.0005767613195645490.00486601304257225
SMARCB1#6598418.25271578115749.00423392720929e-060.000242244509820662
SMARCC1#6599443.66335931963152.74744977017458e-071.40726290606799e-05
SUZ12#23512450.11578091106291.5827390373096e-078.84428476819571e-06
TBP#690843.706770687096390.005296377814784350.024503783228416
USF1#739146.361499277207960.0006105011399140830.0050910354959667
USF2#7392412.99219738506963.50833029870167e-050.000683211836781845



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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